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The present study aimed to validate the Leap Motion Controller (LMC)-based Fizyosoft (R) HandROM System developed by our team to evaluate range of motion (ROM) for fingers, wrist, and forearm in a new clinical setting. Thirty-five healthy individuals participated in the study (all right-handed, 20-30 years old). The LMC-based Fizyosoft (R) HandROM System is a licensed software ROM-measurement developed by our team. Pronation/supination, wrist flexion/extension, ulnar/radial deviation and metacarpophalangeal (MCP) flexion/extension of all fingers were measured with both the Fizyosoft (R) HandROM System and a universal goniometer. No significant differences were found between the two measurement methods for almost all mean ROMs except for ulnar and radial deviation (p > 0.05). Highly significant correlations were found between all ROMs of the forearm, wrist, and thumb (p < 0.01). MCP flexion showed significant correlation only in the index finger (r = 0.516, p = 0.003) and little finger (r = 0.517, p = 0.004). Besides, for both measures, the intraclass correlations were good to excellent on all ROMs of the forearm, wrist, and fingers except for MCP of the middle and ring fingers (0.68-0.88). The present study results indicated that the LMC-based Fizyosoft (R) HandROM System could sensitively track changes in the active motion of the thumb, wrist, and forearm. It is a viable alternative for assessing ROMs of the forearm, wrist, and thumb in patient follow-up. L’objectif de la pre ́sente e ́tude e ́tait de valider le syste`me Fizyosoft1HandROM base ́sur le Leap MotionController (LMC) de ́veloppe ́par notre e ́quipe pour e ́valuer l’amplitude articulaire (ROM) des doigts, dupoignet et de l’avant-bras dans un nouveau contexte clinique. Trente-cinq personnes saines ont participe ́a`cette e ́tude. Le syste`me Fizyosoft1HandROM base ́sur LMC est un logiciel sous licence de ́veloppe ́parnotre e ́quipe pour mesurer l’amplitude articulaire. La mesure de l’amplitude de la pronation/supination,de la flexion/extension et de la de ́viation ulnaire/radiale du poignet, et de la flexion/extensionme ́tacarpo-phalangienne (MCP) de tous les doigts a e ́te ́re ́alise ́e avec le syste`me HandROM et ungoniome`tre universel. Aucune diffe ́rence significative n’a e ́te ́constate ́e lors de la comparaison depresque toutes les moyennes d’amplitude a`l’exception des de ́viations ulnaire/radiale entre deuxme ́thodes de mesure (p > 0,05). Des corre ́lations significatives e ́leve ́es ont e ́te ́trouve ́es pour toutes lesamplitudes de l’avant-bras, du poignet et du pouce, ainsi que la flexion MCP de l’index et de l’auriculaire, mesure ́e par le goniome`tre et via le syste`me HandROM (p < 0,01). En outre, pour les deux mesures, lesICC e ́taient bons a`excellents sur toutes amplitudes de l’avant-bras, du poignet et des doigts, a`l’exceptionde la MCP du majeur et de l’annulaire (0,68–0,88). Les re ́sultats de la pre ́sente e ́tude montrent que lesyste`me Fizyosoft1HandROM base ́sur le LMC peut suivre de manie`re sensible les changements dans lesmouvements actifs du pouce, du poignet et de l’avant-bras. Research Fund of Istanbul University-Cerrahpasa, Turkey