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Introduction Adherence to haemophilia A ( HA) treatment may be influenced by patients' beliefs about their condition and treatment. Furthermore, difficulties administering treatment may lead to poor adherence. New treatment strategies aim to reduce the burden associated with administration and to improve patient perception of treatment, which, in turn, increase adherence levels. Aims This study aimed to examine patient perception of HA treatment and related factors using patient-reported outcome ( PRO) questionnaires and to confirm the psychometric properties of a recently developed questionnaire, the Haemo PREF. Methods A non-interventional, cross-sectional, questionnaire study was conducted with adult HA patients in Spain (n=31), Germany (n=10) and Italy (n=48), who were using ReFacto AF with the Fuse NGo administration device. Patients completed the Haemo PREF and other questionnaires measuring related constructs: treatment adherence, satisfaction and well-being, online at two time points. Correlational, regression and psychometric analyses were conducted. Results PRO scores indicated that patients are satisfied with and adherent to their treatment. Multivariate regression of the Haemo PREF global score identified a number of significant predictors ( P≤.05). The Haemo PREF Global Score had a moderate relationship with subscales on the related questionnaires (mean correlation=0.43; range=0.39-0.48). The Haemo PREF demonstrated good test-retest reliability (intraclass correlation coefficient=0.82), internal consistency reliability (Cronbach's alpha range=0.69-0.82) and convergent validity with measures of treatment satisfaction (Spearman correlation coefficient, r=.48) and well-being ( r=.41). Conclusion The findings suggest that patients using ReFacto AF with Fuse NGo were satisfied with and adherent to their treatment. The Haemo PREF can identify important concepts relating to patient treatment experience in HA. [ABSTRACT FROM AUTHOR]