8 results on '"Anne Lambilliotte"'
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2. Profound and sustained response with next-generation ALK inhibitors in patients with relapsed or progressive ALK-positive anaplastic large cell lymphoma with central nervous system involvement
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Charlotte Rigaud, Samuel Abbou, Stephane Ducassou, Mathieu Simonin, Lou Le Mouel, Victor Pereira, Stephanie Gourdon, Anne Lambilliotte, Birgit Geoerger, Veronique Minard-Colin, and Laurence Brugieres
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2022
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3. Late effects after hematopoietic stem cell transplantation for β-thalassemia major: the French national experience
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Ilhem Rahal, Claire Galambrun, Yves Bertrand, Nathalie Garnier, Catherine Paillard, Pierre Frange, Corinne Pondarré, Jean Hugues Dalle, Regis Peffault de Latour, Mauricette Michallet, Dominique Steschenko, Despina Moshous, Patrick Lutz, Jean Louis Stephan, Pierre Simon Rohrlich, Ibrahim Yakoub-Agha, Françoise Bernaudin, Christophe Piguet, Nathalie Aladjidi, Catherine Badens, Claire Berger, Gérard Socié, Cécile Dumesnil, Marie Pierre Castex, Marilyne Poirée, Anne Lambilliotte, Caroline Thomas, Pauline Simon, Pascal Auquier, Gérard Michel, Anderson Loundou, Imane Agouti, and Isabelle Thuret
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
In this retrospective study, we evaluate long-term complications in nearly all β-thalassemia-major patients who successfully received allogeneic hematopoietic stem cell transplantation in France. Ninety-nine patients were analyzed with a median age of 5.9 years at transplantation. The median duration of clinical follow up was 12 years. All conditioning regimens were myeloablative, most were based on busulfan combined with cyclophosphamide, and more than 90% of patients underwent a transplant from a matched sibling donor. After transplantation, 11% of patients developed thyroid dysfunction, 5% diabetes, and 2% heart failure. Hypogonadism was present in 56% of females and 14% of males. Female patients who went on to normal puberty after transplant were significantly younger at transplantation than those who experienced delayed puberty (median age 2.5 vs. 8.7 years). Fertility was preserved in 9 of 27 females aged 20 years or older and 2 other patients became pregnant following oocyte donation. In addition to patient’s age and higher serum ferritin levels at transplantation, time elapsed since transplant was significantly associated with decreased height growth in multivariate analysis. Weight growth increased after transplantation particularly in females, 36% of adults being overweight at last evaluation. A comprehensive long-term monitoring, especially of endocrine late effects, is required after hematopoietic stem cell transplantation for thalassemia.
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- 2018
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4. Classification of and risk factors for hematologic complications in a French national cohort of 102 patients with Shwachman-Diamond syndrome
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Jean Donadieu, Odile Fenneteau, Blandine Beaupain, Sandrine Beaufils, Florence Bellanger, Nizar Mahlaoui, Anne Lambilliotte, Nathalie Aladjidi, Yves Bertrand, Valérie Mialou, Christine Perot, Gérard Michel, Fanny Fouyssac, Catherine Paillard, Virginie Gandemer, Patrick Boutard, Jacques Schmitz, Alain Morali, Thierry Leblanc, Christine Bellanné-Chantelot, and the associated investigators of the French Severe Chronic Neutropenia Registry
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Background Patients with the Shwachman-Diamond syndrome often develop hematologic complications. No risk factors for these complications have so far been identified. The aim of this study was to classify the hematologic complications occurring in patients with Shwachman-Diamond syndrome and to investigate the risk factors for these complications.Design and Methods One hundred and two patients with Shwachman-Diamond syndrome, with a median follow-up of 11.6 years, were studied. Major hematologic complications were considered in the case of definitive severe cytopenia (i.e. anemia
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- 2012
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5. A novel (ɛγδβ)°-thalassemia deletion associated with an α globin gene triplication leading to a severe transfusion dependant fetal thalassemic syndrome
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Christian Rose, Julien Rossignol, Anne Lambilliotte, Sandrine Depret, Nathalie Le Metayer, and Serge Pissard
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Diseases of the blood and blood-forming organs ,RC633-647.5 - Published
- 2009
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6. Classification of and risk factors for hematologic complications in a French national cohort of 102 patients with Shwachman-Diamond syndrome
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Christine Perot, Thierry Leblanc, Jean Donadieu, Odile Fenneteau, Christine Bellanné-Chantelot, Fanny Fouyssac, Anne Lambilliotte, Gérard Michel, Patrick Boutard, Catherine Paillard, Alain Morali, Nizar Mahlaoui, Florence Bellanger, Sandrine Beaufils, Valérie Mialou, Nathalie Aladjidi, Virginie Gandemer, Jacques Schmitz, Yves Bertrand, Blandine Beaupain, CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'Hématologie Biologique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré, AP-HP, CHU Pitié-Salpêtrière [AP-HP], IFR Necker-Enfants Malades (IRNEM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service d'hématologie pédiatrique-oncologie, Hôpital Jeanne de Flandre [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service d'Hémato-oncologie Pédiatrique, CHU Bordeaux [Bordeaux]-Hôpital Pellegrin, Service de pédiatrie, Hospices Civils de Lyon (HCL)-Hôpital Debrousse, Hospices Civils de Lyon (HCL)-Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL] (IHOPe), Hospices Civils de Lyon (HCL), Centre de Recherche Saint-Antoine (UMRS893), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital de la Timone [CHU - APHM] (TIMONE), Service d'Hématologie et d'Oncologie Pédiatrique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service d'Hémato-oncologie pédiatrique, CHU Clermont-Ferrand, Service d'hématologie-oncologie pédiatrique, CHU Pontchaillou [Rennes], Unité d'hémato-immuno-oncologie pédiatrique [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de Gastro-entérologie Pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Gastro-Entérologie Pédiatrique [CHRU Nancy], Service d'hématologie et immunologie pédiatrique, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), The French registry is supported by grants from Amgen SAS, Chugai SA, GIS Maladies Rares, Institut de veille sanitaire and Inserm. This project is supported by a grant from Association Laurette Fugain and by constant and unlimited support of the Association Sportive de Saint Quentin Fallavier since 2004 with the unlimited commitment of Mr Gonnot., Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Service de Génétique Cytogénétique et Embryologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Université Paris Diderot - Paris 7 (UPD7)-Hôpital Robert Debré-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'hématologie-immunologie-oncologie pédiatrique, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Robert Debré, AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], IFR Necker-Enfants Malades ( IRNEM ), Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Hôpital Jeanne de Flandre [Lille]-Centre Hospitalier Régional Universitaire [Lille] ( CHRU Lille ), Hospices Civils de Lyon ( HCL ) -Hôpital Debrousse, Hospices Civils de Lyon ( HCL ) -Institut d'hématologie et d'oncologie pédiatrique [CHU - HCL] ( IHOPe ), Hospices Civils de Lyon ( HCL ), Centre de Recherche Saint-Antoine ( CR Saint-Antoine ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université Pierre et Marie Curie - Paris 6 ( UPMC ), Hôpital de la Timone [CHU - APHM] ( TIMONE ), Centre Hospitalier Régional Universitaire de Nancy ( CHRU Nancy ), Assistance publique - Hôpitaux de Paris (AP-HP)-Université Paris Descartes - Paris 5 ( UPD5 ) -CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 ( UPD7 ), and De Villemeur, Hervé
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[SDV.MHEP.HEM] Life Sciences [q-bio]/Human health and pathology/Hematology ,Male ,Pathology ,Pediatrics ,genotype ,Lipomatosis ,[SDV.GEN] Life Sciences [q-bio]/Genetics ,secondary leukemia ,0302 clinical medicine ,Risk Factors ,hemic and lymphatic diseases ,[ SDV.MHEP.HEM ] Life Sciences [q-bio]/Human health and pathology/Hematology ,cytopenia ,Prospective Studies ,Registries ,Prospective cohort study ,Bone Marrow Diseases ,[SDV.BDD]Life Sciences [q-bio]/Development Biology ,Shwachman–Diamond syndrome ,Shwachman-Diamond syndrome ,[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/Hematology ,Hematology ,Prognosis ,3. Good health ,Survival Rate ,Leukemia ,030220 oncology & carcinogenesis ,Female ,France ,medicine.medical_specialty ,aplastic anemia ,Anemia ,monosomy 7 ,macromolecular substances ,03 medical and health sciences ,[SDV.BDD] Life Sciences [q-bio]/Development Biology ,medicine ,Humans ,[ SDV.BDD ] Life Sciences [q-bio]/Development Biology ,Aplastic anemia ,Survival rate ,[SDV.GEN]Life Sciences [q-bio]/Genetics ,Cytopenia ,business.industry ,Infant ,medicine.disease ,Hematologic Diseases ,Exocrine Pancreatic Insufficiency ,Original Articles and Brief Reports ,[ SDV.GEN ] Life Sciences [q-bio]/Genetics ,myelodysplasia ,business ,Follow-Up Studies ,030215 immunology - Abstract
International audience; BACKGROUND: Patients with the Shwachman-Diamond syndrome often develop hematologic complications. No risk factors for these complications have so far been identified. The aim of this study was to classify the hematologic complications occurring in patients with Shwachman-Diamond syndrome and to investigate the risk factors for these complications. DESIGN AND METHODS: One hundred and two patients with Shwachman-Diamond syndrome, with a median follow-up of 11.6 years, were studied. Major hematologic complications were considered in the case of definitive severe cytopenia (i.e. anemia
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- 2012
- Full Text
- View/download PDF
7. A novel (epsilongammadeltabeta)(o)-thalassemia deletion associated with an alpha globin gene triplication leading to a severe transfusion dependent fetal thalassemic syndrome
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Christian, Rose, Julien, Rossignol, Anne, Lambilliotte, Sandrine, Depret, Nathalie, Le Metayer, and Serge, Pissard
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Adult ,Male ,Hydrops Fetalis ,Infant, Newborn ,Pedigree ,alpha-Globins ,Pregnancy ,Gene Duplication ,Humans ,Thalassemia ,Blood Transfusion ,Female ,Letter to the Editor ,Sequence Deletion - Published
- 2009
8. A novel ( ) -thalassemia deletion associated with an globin gene triplication leading to a severe transfusion dependant fetal thalassemic syndrome
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Julien Rossignol, Anne Lambilliotte, Serge Pissard, Christian Rose, Sandrine Depret, and Nathalie Le Metayer
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Hemolytic anemia ,Thalassemia ,Heterozygote advantage ,Hematology ,Biology ,medicine.disease ,Molecular biology ,Hemoglobinopathy ,Hydrops fetalis ,Immunology ,Gene duplication ,medicine ,Globin ,Alpha globulin - Abstract
(ɛγδβ)°-thalassemia is a very rare form of thalassemia only recognized in heterozygotes and caused by unique and sporadic deletions.[1][1]–[3][2] The α/non α–globin chain ratio is imbalanced like in β thalassemia patients but without elevation of HbF or HbA2.[4][3] They are characterized
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- 2009
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