1. Woman with virilizing congenital adrenal hyperplasia and leydig cell tumor of the ovary
- Author
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Carmen Muñoz-Darias, Rosario Fernández-García Salazar, Laura Audí, Juan J. Haro-Mora, M. Cruz Almaraz, Juana Martínez-Tudela, Isabel Esteva, and Raquel Yahyaoui
- Subjects
Adult ,medicine.medical_specialty ,endocrine system diseases ,medicine.drug_class ,Endocrinology, Diabetes and Metabolism ,Physiology ,Ovary ,Ovarian Hilus Cell Tumor ,Ovarian tumor ,Endocrinology ,Internal medicine ,medicine ,Humans ,Congenital adrenal hyperplasia ,Testosterone ,Ovarian Neoplasms ,Adrenal Hyperplasia, Congenital ,business.industry ,Virilization ,Obstetrics and Gynecology ,medicine.disease ,Virilism ,medicine.anatomical_structure ,Leydig Cell Tumor ,Corticosteroid ,Female ,medicine.symptom ,business - Abstract
We report the case of a 36-year-old woman with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, and corticosteroid replacement therapy since birth. She manifested persistent virilization and high testosterone levels that were attributed to nonadherence to medical treatment. The patient was referred to our gender unit for genitoplastic surgery. We recommended the patient for left oophorectomy after detecting an ovarian mass. Pathologic findings confirmed an ovarian hilus cell tumor. Testosterone levels fell back to normal and masculinization disappeared but ACTH remained elevated. This case represents a very rare type of primary ovarian tumor that must be considered in persistent virilizing symptoms in women with CAH.
- Published
- 2014
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