1. Factors that influence survival in high-grade serous ovarian cancer: A complex relationship between molecular subtype, disease dissemination, and operability
- Author
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Torres, Diogo, Wang, Chen, Kumar, Amanika, Bakkum-Gamez, Jamie N, Weaver, Amy L, McGree, Michaela E, Konecny, Gottfried E, Goode, Ellen L, and Cliby, William A
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Oncology and Carcinogenesis ,Ovarian Cancer ,Cancer ,Clinical Research ,Rare Diseases ,2.1 Biological and endogenous factors ,Aetiology ,Good Health and Well Being ,Cystadenocarcinoma ,Serous ,Female ,Humans ,Middle Aged ,Neoplasm Staging ,Ovarian Neoplasms ,Proportional Hazards Models ,Survival Rate ,High-grade serous ovarian cancer ,Epithelial ovarian cancer ,Mesenchymal ,Residual disease ,TCGA subtype ,Molecular subtype ,Paediatrics and Reproductive Medicine ,Oncology & Carcinogenesis ,Clinical sciences ,Oncology and carcinogenesis ,Reproductive medicine - Abstract
ObjectiveTo investigate the relationship between molecular subtype, intraperitoneal (IP) disease dissemination patterns, resectability, and overall survival (OS) in advanced high-grade serous ovarian cancer (HGSOC).MethodsPatients undergoing primary surgery for stage III-IV HGSOC at Mayo Clinic from 1994 to 2011 were categorized into three IP disease dissemination patterns: upper abdominal or miliary; lower abdominal; and pelvic. Residual disease was defined as 0 (RD0), 0.1-0.5, 0.6-1.0, or >1 cm. Molecular subtypes were derived from Agilent 4x44k tumor mRNA expression profiles and categorized as mesenchymal (MES) or non-mesenchymal (non-MES).ResultsOperative and molecular data was available for 334 patients. Median OS was shorter in patients with MES compared to non-MES subtypes (34.2 vs 44.6 months; P = 0.009). Patients with MES subtype were more likely to have upper abdominal/miliary disease compared to non-MES subtype (90% vs. 72%, P
- Published
- 2018