1. N-Acetylcysteine Improves Pancreatic Microcirculation and Alleviates the Severity of Acute Necrotizing Pancreatitis
- Author
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Xu Bao Liu, Yong-Hua Chen, Yue-Ming Yang, Bing-Qing Du, and Gang Mai
- Subjects
Acute necrotizing pancreatitis ,Pathology ,medicine.medical_specialty ,Liver, Pancreas and Biliary Tract ,Gastroenterology ,Acetylcysteine ,chemistry.chemical_compound ,Pancreatic microvascular perfusion ,Internal medicine ,medicine ,Pancreatic microcirculation ,Hepatology ,business.industry ,Laser-Doppler flowmetry ,Laser Doppler velocimetry ,Taurocholic acid ,Microvascular perfusion ,chemistry ,cardiovascular system ,Original Article ,business ,hormones, hormone substitutes, and hormone antagonists ,circulatory and respiratory physiology ,medicine.drug - Abstract
Background/Aims To investigate the beneficial effect of N-Acetylcysteine (NAC) on pancreatic microvascular perfusion in acute necrotizing pancreatitis (ANP). Methods Fifty-four rats were divided into a control group, an ANP group and an NAC-treated group. The ANP model was established by a retrograde injection of 3% sodium taurocholate into the pancreatic duct. The NAC-treated group received an intravenous infusion of NAC just 2 hours before and 30 minutes after the induction of ANP. The pancreatic microvascular perfusion was measured with laser Doppler flowmetry and pancreatic samples were collected for histological examination. Results The microvascular perfusion in the NAC-treated group decreased slightly and exhibited a significant increase compared to the ANP group (p
- Published
- 2013
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