1. Determinants of reflux-induced chronic cough
- Author
-
Albert J. Bredenoord, Ans Pauwels, André J.P.M. Smout, Daniel Sifrim, T. V. K. Herregods, Jan Tack, Jafar Jafari, Other departments, Gastroenterology and Hepatology, and AGEM - Amsterdam Gastroenterology Endocrinology Metabolism
- Subjects
Male ,medicine.medical_specialty ,Manometry ,Unexplained cough ,Gastroenterology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Electric Impedance ,Humans ,business.industry ,digestive, oral, and skin physiology ,Reflux ,Ambulatory pH monitoring ,Hydrogen-Ion Concentration ,Middle Aged ,digestive system diseases ,respiratory tract diseases ,Chronic cough ,030228 respiratory system ,Cough ,Anesthesia ,Chronic Disease ,Gastroesophageal Reflux ,030211 gastroenterology & hepatology ,Female ,Antacids ,medicine.symptom ,business - Abstract
ObjectiveGastro-oesophageal reflux is considered to be an important contributing factor in chronic unexplained cough. It remains unclear why some reflux episodes in the same patient causes cough while others do not. To understand more about the mechanism by which reflux induces cough, we aimed to identify factors which are important in triggering cough.DesignIn this multicentre study, 49 patients with reflux-associated chronic cough were analysed using 24-hour pH-impedance-pressure monitoring. The characteristics of reflux episodes that were followed by cough were compared with reflux episodes not associated with cough.ResultsThe majority (72.4%) of the reflux episodes were acidic (pHConclusionsThe presence of a larger volume of refluxate and oesophageal exposure to reflux for a longer period of time seems to play an important role in inducing cough, while the acidity of the refluxate seems to be less relevant. This helps explain the observation that most patients with chronic cough tend not to benefit from acid inhibitory treatment.
- Published
- 2017