1. Endotoxaemia and serum tumour necrosis factor as prognostic markers in severe acute pancreatitis
- Author
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R A Swann, A R Exley, T Leese, M P Holliday, and J Cohen
- Subjects
Male ,medicine.medical_specialty ,Pathology ,Necrosis ,Pancreatic disease ,medicine.medical_treatment ,Gastroenterology ,Interquartile range ,Internal medicine ,medicine ,Humans ,Aged ,Aged, 80 and over ,business.industry ,Septic shock ,Tumor Necrosis Factor-alpha ,Middle Aged ,medicine.disease ,Prognosis ,Endotoxins ,Cytokine ,Pancreatitis ,Acute Disease ,Acute pancreatitis ,Tumor necrosis factor alpha ,Female ,medicine.symptom ,business ,Research Article - Abstract
Endotoxaemia and circulating tumour necrosis factor are important prognostic factors in severe sepsis and are implicated in the pathogenesis of septic shock. Because clinical and pathological features in acute pancreatitis are similar to septic shock this study sought to determine whether endotoxin and tumour necrosis factor were prognostic factors in 38 patients with prognostically severe acute pancreatitis. Endotoxaemia, present in 19/37 (51%) patients on day 1, was more common in nonsurvivors than survivors (10/11, 91% v 9/26, 35%, p = 0.003). Day 1 serum endotoxin concentrations were higher in patients with a severe outcome (median (interquartile range) 314 (173-563) pg/ml v 0 (0-185) pg/ml, p
- Published
- 1992