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2. Lifestyle factors for the prevention of inflammatory bowel disease

Author

Lopes, Emily W, primary, Chan, Simon S M, additional, Song, Mingyang, additional, Ludvigsson, Jonas F, additional, Håkansson, Niclas, additional, Lochhead, Paul, additional, Clark, Allan, additional, Burke, Kristin E, additional, Ananthakrishnan, Ashwin N, additional, Cross, Amanda J, additional, Palli, Domenico, additional, Bergmann, Manuela M, additional, Richter, James M, additional, Chan, Andrew T, additional, Olén, Ola, additional, Wolk, Alicja, additional, and Khalili, Hamed, additional

Published
2022
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5. Lifestyle factors for the prevention of inflammatory bowel disease

Author

Lopes, Emily W, Chan, Simon S M, Song, Mingyang, Ludvigsson, Jonas F, Håkansson, Niclas, Lochhead, Paul, Clark, Allan, Burke, Kristin E, Ananthakrishnan, Ashwin N, Cross, Amanda J, Palli, Domenico, Bergmann, Manuela M, Richter, James M, Chan, Andrew T, Olén, Ola, Wolk, Alicja, and Khalili, Hamed

Abstract

ObjectiveTo estimate the proportion of cases of Crohn’s disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors.DesignIn a prospective cohort study of US adults from the Nurses’ Health Study (NHS; n=72 290), NHSII (n=93 909) and Health Professionals Follow-up Study (HPFS; n=41 871), we created modifiable risk scores (MRS; 0–6) for CD and UC based on established lifestyle risk factors, and healthy lifestyle scores (HLS; 0–9) derived from American healthy lifestyle recommendations. We calculated the population attributable risk by comparing the incidence of CD and UC between low-risk (CD-MRS≤1, UC-MRS≤2, HLS≥7) and high-risk groups. We externally validated our findings in three European cohorts: the Swedish Mammography Cohort (n=37 275), Cohort of Swedish Men (n=40 810) and European Prospective Investigation into Cancer and Nutrition (n=404 144).ResultsOver 5 117 021 person-years of follow-up (NHS, HPFS: 1986–2016; NHSII: 1991–2017), we documented 346 CD and 456 UC cases. Adherence to a low MRS could have prevented 42.9% (95% CI 12.2% to 66.1%) of CD and 44.4% (95% CI 9.0% to 69.8%) of UC cases. Similarly, adherence to a healthy lifestyle could have prevented 61.1% (95% CI 16.8% to 84.9%) of CD and 42.2% (95% CI 1.7% to 70.9%) of UC cases. In our validation cohorts, adherence to a low MRS and healthy lifestyle could have, respectively, prevented 43.9%–51.2% and 48.8%–60.4% of CD cases and 20.6%–27.8% and 46.8%–56.3% of UC cases.ConclusionsAcross six US and European cohorts, a substantial burden of inflammatory bowel diseases risk may be preventable through lifestyle modification.

Published
2023
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6. Genetic architectures of proximal and distal colorectal cancer are partly distinct

Author

Huyghe, Jeroen R, primary, Harrison, Tabitha A, additional, Bien, Stephanie A, additional, Hampel, Heather, additional, Figueiredo, Jane C, additional, Schmit, Stephanie L, additional, Conti, David V, additional, Chen, Sai, additional, Qu, Conghui, additional, Lin, Yi, additional, Barfield, Richard, additional, Baron, John A, additional, Cross, Amanda J, additional, Diergaarde, Brenda, additional, Duggan, David, additional, Harlid, Sophia, additional, Imaz, Liher, additional, Kang, Hyun Min, additional, Levine, David M, additional, Perduca, Vittorio, additional, Perez-Cornago, Aurora, additional, Sakoda, Lori C, additional, Schumacher, Fredrick R, additional, Slattery, Martha L, additional, Toland, Amanda E, additional, van Duijnhoven, Fränzel J B, additional, Van Guelpen, Bethany, additional, Agudo, Antonio, additional, Albanes, Demetrius, additional, Alonso, M Henar, additional, Anderson, Kristin, additional, Arnau-Collell, Coral, additional, Arndt, Volker, additional, Banbury, Barbara L, additional, Bassik, Michael C, additional, Berndt, Sonja I, additional, Bézieau, Stéphane, additional, Bishop, D Timothy, additional, Boehm, Juergen, additional, Boeing, Heiner, additional, Boutron-Ruault, Marie-Christine, additional, Brenner, Hermann, additional, Brezina, Stefanie, additional, Buch, Stephan, additional, Buchanan, Daniel D, additional, Burnett-Hartman, Andrea, additional, Caan, Bette J, additional, Campbell, Peter T, additional, Carr, Prudence R, additional, Castells, Antoni, additional, Castellví-Bel, Sergi, additional, Chan, Andrew T, additional, Chang-Claude, Jenny, additional, Chanock, Stephen J, additional, Curtis, Keith R, additional, de la Chapelle, Albert, additional, Easton, Douglas F, additional, English, Dallas R, additional, Feskens, Edith J M, additional, Gala, Manish, additional, Gallinger, Steven J, additional, Gauderman, W James, additional, Giles, Graham G, additional, Goodman, Phyllis J, additional, Grady, William M, additional, Grove, John S, additional, Gsur, Andrea, additional, Gunter, Marc J, additional, Haile, Robert W, additional, Hampe, Jochen, additional, Hoffmeister, Michael, additional, Hopper, John L, additional, Hsu, Wan-Ling, additional, Huang, Wen-Yi, additional, Hudson, Thomas J, additional, Jenab, Mazda, additional, Jenkins, Mark A, additional, Joshi, Amit D, additional, Keku, Temitope O, additional, Kooperberg, Charles, additional, Kühn, Tilman, additional, Küry, Sébastien, additional, Le Marchand, Loic, additional, Lejbkowicz, Flavio, additional, Li, Christopher I, additional, Li, Li, additional, Lieb, Wolfgang, additional, Lindblom, Annika, additional, Lindor, Noralane M, additional, Männistö, Satu, additional, Markowitz, Sanford D, additional, Milne, Roger L, additional, Moreno, Lorena, additional, Murphy, Neil, additional, Nassir, Rami, additional, Offit, Kenneth, additional, Ogino, Shuji, additional, Panico, Salvatore, additional, Parfrey, Patrick S, additional, Pearlman, Rachel, additional, Pharoah, Paul D P, additional, Phipps, Amanda I, additional, Platz, Elizabeth A, additional, Potter, John D, additional, Prentice, Ross L, additional, Qi, Lihong, additional, Raskin, Leon, additional, Rennert, Gad, additional, Rennert, Hedy S, additional, Riboli, Elio, additional, Schafmayer, Clemens, additional, Schoen, Robert E, additional, Seminara, Daniela, additional, Song, Mingyang, additional, Su, Yu-Ru, additional, Tangen, Catherine M, additional, Thibodeau, Stephen N, additional, Thomas, Duncan C, additional, Trichopoulou, Antonia, additional, Ulrich, Cornelia M, additional, Visvanathan, Kala, additional, Vodicka, Pavel, additional, Vodickova, Ludmila, additional, Vymetalkova, Veronika, additional, Weigl, Korbinian, additional, Weinstein, Stephanie J, additional, White, Emily, additional, Wolk, Alicja, additional, Woods, Michael O, additional, Wu, Anna H, additional, Abecasis, Goncalo R, additional, Nickerson, Deborah A, additional, Scacheri, Peter C, additional, Kundaje, Anshul, additional, Casey, Graham, additional, Gruber, Stephen B, additional, Hsu, Li, additional, Moreno, Victor, additional, Hayes, Richard B, additional, Newcomb, Polly A, additional, and Peters, Ulrike, additional

Published
2021
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10. Long-term use of antibiotics and risk of colorectal adenoma

Author

Cao, Yin, primary, Wu, Kana, additional, Mehta, Raaj, additional, Drew, David A, additional, Song, Mingyang, additional, Lochhead, Paul, additional, Nguyen, Long H, additional, Izard, Jacques, additional, Fuchs, Charles S, additional, Garrett, Wendy S, additional, Huttenhower, Curtis, additional, Ogino, Shuji, additional, Giovannucci, Edward L, additional, and Chan, Andrew T, additional

Published
2017
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12. Tumour CD274 (PD-L1) expression and T cells in colorectal cancer

Author

Masugi, Yohei, primary, Nishihara, Reiko, additional, Yang, Juhong, additional, Mima, Kosuke, additional, da Silva, Annacarolina, additional, Shi, Yan, additional, Inamura, Kentaro, additional, Cao, Yin, additional, Song, Mingyang, additional, Nowak, Jonathan A, additional, Liao, Xiaoyun, additional, Nosho, Katsuhiko, additional, Chan, Andrew T, additional, Giannakis, Marios, additional, Bass, Adam J, additional, Hodi, F Stephen, additional, Freeman, Gordon J, additional, Rodig, Scott, additional, Fuchs, Charles S, additional, Qian, Zhi Rong, additional, and Ogino, Shuji, additional

Published
2016
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13. Fusobacterium nucleatumin colorectal carcinoma tissue and patient prognosis

Author

Mima, Kosuke, primary, Nishihara, Reiko, additional, Qian, Zhi Rong, additional, Cao, Yin, additional, Sukawa, Yasutaka, additional, Nowak, Jonathan A, additional, Yang, Juhong, additional, Dou, Ruoxu, additional, Masugi, Yohei, additional, Song, Mingyang, additional, Kostic, Aleksandar D, additional, Giannakis, Marios, additional, Bullman, Susan, additional, Milner, Danny A, additional, Baba, Hideo, additional, Giovannucci, Edward L, additional, Garraway, Levi A, additional, Freeman, Gordon J, additional, Dranoff, Glenn, additional, Garrett, Wendy S, additional, Huttenhower, Curtis, additional, Meyerson, Matthew, additional, Meyerhardt, Jeffrey A, additional, Chan, Andrew T, additional, Fuchs, Charles S, additional, and Ogino, Shuji, additional

Published
2015
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14. Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status

Author

Song, Mingyang, primary, Nishihara, Reiko, additional, Wang, Molin, additional, Chan, Andrew T, additional, Qian, Zhi Rong, additional, Inamura, Kentaro, additional, Zhang, Xuehong, additional, Ng, Kimmie, additional, Kim, Sun A, additional, Mima, Kosuke, additional, Sukawa, Yasutaka, additional, Nosho, Katsuhiko, additional, Fuchs, Charles S, additional, Giovannucci, Edward L, additional, Wu, Kana, additional, and Ogino, Shuji, additional

Published
2015
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15. Long-term use of antibiotics and risk of colorectal adenoma

Author

Cao, Yin, Wu, Kana, Mehta, Raaj, Drew, David A, Song, Mingyang, Lochhead, Paul, Nguyen, Long H, Izard, Jacques, Fuchs, Charles S, Garrett, Wendy S, Huttenhower, Curtis, Ogino, Shuji, Giovannucci, Edward L, and Chan, Andrew T

Abstract

ObjectiveRecent evidence suggests that antibiotic use, which alters the gut microbiome, is associated with an increased risk of colorectal cancer. However, the association between antibiotic use and risk of colorectal adenoma, the precursor for the majority of colorectal cancers, has not been investigated.DesignWe prospectively evaluated the association between antibiotic use at age 20–39 and 40–59 (assessed in 2004) and recent antibiotic use (assessed in 2008) with risk of subsequent colorectal adenoma among 16 642 women aged ≥60 enrolled in the Nurses' Health Study who underwent at least one colonoscopy through 2010. We used multivariate logistic regression to calculate ORs and 95% CIs.ResultsWe documented 1195 cases of adenoma. Increasing duration of antibiotic use at age 20–39 (ptrend=0.002) and 40–59 (ptrend=0.001) was significantly associated with an increased risk of colorectal adenoma. Compared with non-users, women who used antibiotics for ≥2 months between age 20 and 39 had a multivariable OR of 1.36 (95% CI 1.03 to 1.79). Women who used ≥2 months of antibiotics between age 40 and 59 had a multivariable OR of 1.69 (95% CI 1.24 to 2.31). The associations were similar for low-risk versus high-risk adenomas (size ≥1 cm, or with tubulovillous/villous histology, or ≥3 detected lesions), but appeared modestly stronger for proximal compared with distal adenomas. In contrast, recent antibiotic use within the past four years was not associated with risk of adenoma (ptrend=0.44).ConclusionsLong-term antibiotic use in early-to-middle adulthood was associated with increased risk of colorectal adenoma.

Published
2018
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16. Tumour CD274 (PD-L1) expression and T cells in colorectal cancer

Author

Masugi, Yohei, Nishihara, Reiko, Yang, Juhong, Mima, Kosuke, da Silva, Annacarolina, Shi, Yan, Inamura, Kentaro, Cao, Yin, Song, Mingyang, Nowak, Jonathan A, Liao, Xiaoyun, Nosho, Katsuhiko, Chan, Andrew T, Giannakis, Marios, Bass, Adam J, Hodi, F Stephen, Freeman, Gordon J, Rodig, Scott, Fuchs, Charles S, Qian, Zhi Rong, and Ogino, Shuji

Abstract

ObjectiveEvidence suggests that CD274 (programmed death-ligand 1, B7-H1) immune checkpoint ligand repress antitumour immunity through its interaction with the PDCD1 (programmed cell death 1, PD-1) receptor of T lymphocytes in various tumours. We hypothesised that tumour CD274 expression levels might be inversely associated with T-cell densities in colorectal carcinoma tissue.DesignWe evaluated tumour CD274 expression by immunohistochemistry in 823 rectal and colon cancer cases within the Nurses' Health Study and Health Professionals Follow-up Study. We conducted multivariable ordinal logistic regression analyses to examine the association of tumour CD274 expression with CD3+, CD8+, CD45RO (PTPRC)+or FOXP3+cell density in tumour tissue, controlling for potential confounders including tumour status of microsatellite instability (MSI), CpG island methylator phenotype, long interspersed nucleotide element-1 methylation level and KRAS, BRAFand PIK3CAmutations.ResultsCD274 expression in tumour cells or stromal cells (including immune cells) was detected in 731 (89%) or 44 (5%) cases, respectively. Tumour CD274 expression level correlated inversely with FOXP3+cell density in colorectal cancer tissue (outcome) (ptrend=0.0002). For a unit increase in outcome quartile categories, multivariable OR in the highest (vs lowest) CD274 expression score was 0.22 (95% CI 0.10 to 0.47). Tumour CD274 expression was inversely associated with MSI-high status (p=0.001). CD274 expression was not significantly associated with CD3+, CD8+or CD45RO+cell density, pathological lymphocytic reactions or patient survival prognosis.ConclusionsTumour CD274 expression is inversely associated with FOXP3+cell density in colorectal cancer tissue, suggesting a possible influence of CD274-expressing carcinoma cells on regulatory T cells in the tumour microenvironment.

Published
2017
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18. Yogurt consumption and risk of conventional and serrated precursors of colorectal cancer.

Author

Zheng X, Wu K, Song M, Ogino S, Fuchs CS, Chan AT, Giovannucci EL, Cao Y, and Zhang X

Subjects
Humans, Life Style, Yogurt, Adenoma, Colonic Neoplasms, Colorectal Neoplasms
Abstract

Competing Interests: Competing interests: Charles S. Fuchs reports consulting role for Agios, Bain Capital, Bayer, Celgene, Dicerna, Five Prime Therapeutics, Gilead Sciences, Eli Lilly, Entrinsic Health, Genentech, KEW, Merck, Merrimack Pharmaceuticals, Pfizer, Sanofi, Taiho, and Unum Therapeutics. He also serves as a Director for CytomX Therapeutics and owns unexercised stock options for CytomX and Entrinsic Health.

Published
2020
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19. Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.

Author

Mima K, Nishihara R, Qian ZR, Cao Y, Sukawa Y, Nowak JA, Yang J, Dou R, Masugi Y, Song M, Kostic AD, Giannakis M, Bullman S, Milner DA, Baba H, Giovannucci EL, Garraway LA, Freeman GJ, Dranoff G, Garrett WS, Huttenhower C, Meyerson M, Meyerhardt JA, Chan AT, Fuchs CS, and Ogino S

Subjects
Aged, Carcinoma mortality, Carcinoma pathology, Class I Phosphatidylinositol 3-Kinases, Colorectal Neoplasms mortality, Colorectal Neoplasms pathology, Databases, Factual, Female, Follow-Up Studies, Fusobacterium nucleatum genetics, Humans, Kaplan-Meier Estimate, Male, Microsatellite Instability, Middle Aged, Mutation, Neoplasm Staging, Phenotype, Phosphatidylinositol 3-Kinases genetics, Prognosis, Prospective Studies, Proto-Oncogene Proteins B-raf genetics, Proto-Oncogene Proteins p21(ras) genetics, Research Design, Biomarkers, Tumor genetics, Carcinoma genetics, Carcinoma microbiology, Colorectal Neoplasms genetics, Colorectal Neoplasms microbiology, Fusobacterium nucleatum pathogenicity
Abstract

Objective: Accumulating evidence links the intestinal microbiota and colorectal carcinogenesis. Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-mediated immune responses against colorectal tumours. Thus, we hypothesised that the amount of F. nucleatum in colorectal carcinoma might be associated with worse clinical outcome., Design: We used molecular pathological epidemiology database of 1069 rectal and colon cancer cases in the Nurses' Health Study and the Health Professionals Follow-up Study, and measured F. nucleatum DNA in carcinoma tissue. Cox proportional hazards model was used to compute hazard ratio (HR), controlling for potential confounders, including microsatellite instability (MSI, mismatch repair deficiency), CpG island methylator phenotype (CIMP), KRAS, BRAF, and PIK3CA mutations, and LINE-1 hypomethylation (low-level methylation)., Results: Compared with F. nucleatum-negative cases, multivariable HRs (95% CI) for colorectal cancer-specific mortality in F. nucleatum-low cases and F. nucleatum-high cases were 1.25 (0.82 to 1.92) and 1.58 (1.04 to 2.39), respectively, (p for trend=0.020). The amount of F. nucleatum was associated with MSI-high (multivariable odd ratio (OR), 5.22; 95% CI 2.86 to 9.55) independent of CIMP and BRAF mutation status, whereas CIMP and BRAF mutation were associated with F. nucleatum only in univariate analyses (p<0.001) but not in multivariate analysis that adjusted for MSI status., Conclusions: The amount of F. nucleatum DNA in colorectal cancer tissue is associated with shorter survival, and may potentially serve as a prognostic biomarker. Our data may have implications in developing cancer prevention and treatment strategies through targeting GI microflora by diet, probiotics and antibiotics., Competing Interests: Dr. Chan previously served as a consultant for Bayer Healthcare, Millennium Pharmaceuticals, Pozen Inc, and Pfizer Inc. This study was not funded by Bayer Healthcare, Millennium Pharmaceuticals, Pozen Inc, or Pfizer Inc. Dr. Meyerson applies a patent on Fusobacterium in colorectal cancer diagnosis, and has ownership interest in and is a consultant and advisory board member for Foundation Medicine. The other authors declare that they have no competing interests., (Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.)

Published
2016
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