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AIM: To evaluate the safety and efficacy by short-term following up of choroidal neovascularization(CNV)in high myopia treated with intravitreal Conbercept. METHODS: Totally 19 eyes from 19 high myopia patients with CNV were reviewed after intravitreal Conbercept therapy. They were all diagnosed in the Ophthalmology Department of our hospital between April 2016 and February 2018. They were between 35 to 73 years old and the average age was 55.40±11.75 years old, 8 male and 11 female. The spherical equivalent refractive error of the 19 eyes was ranged from -19.00D to -7.50D whose mean value was -12.70D±3.23D. All these patients received intravitreal conbercept 0.5mg/0.05mL once per month for 3mo. The clinical features like age, gender, systemic disease, best corrected visual acuity(BCVA)and intraocular pressure(IOP), exudation of CNV by fundus fluorescein angiography(FFA)and central macular thickness(CMT)by optical coherence tomography(OCT)were evaluated before the treatment. The BCVA and IOP were observed after 1d, 1wk, 1mo of each treatment, and the CMT was recorded by OCT after 1wk, 1mo of each treatment, also the variety of CNV that present in FFA was observed after 1mo of the last treatment. These data was compared to the basal data that before intravitreal injection of conbercept to evaluate the clinical efficacy, and the adverse drug reaction was noticed as well. SPSS was used to analysis the change of parameters after treatment for CNV secondary to high myopia. RESULTS: The pre-injection mean BCVA(LogMAR)at baseline was 0.98±0.29. At the last follow-up visit, the mean post-injection LogMAR BCVA was 0.64±0.16. CMT improved from 324.9±55.6μm to 248.7±17.7μm. The mean post-injection LogMAR BCVA and CMT after each time treatment were both improved than before treatment(P<0.05). However, the data observed after injection was not improved between each other(P>0.05). In these 19 patients, elevated IOP did not occur, besides individual patients had conjunctival hemorrhage, no other significant ocular or systemic injection complications or drug-related side effects were observed. CONCLUSION: The outcomes of this small case series suggest intravitreal Conbercept to be a safe and promising treatment method for CNV secondary to high myopia with both visual and anatomic improvements and the effect is obvious at the first time injection.

AIM:To observe the changes of anterior segment before and after phacoemulsification and intraocular lens implantation in patients with primary angle-closure glaucoma(PACG)by Pentacam system,so as to assess the efficacy and the influence factors for treating PACG.METHODS:One hundred and sixty-three patients(178 eyes)with PACG were included in the presented study, which were classified to acute PACG(APACG, 87 patients with 92 yes)and chronic PACG(CPACG, 76 patients with 86 eyes).Phacoemulsification and posterior-chamber IOL(PC-IOL)implantations were performed for all eyes and combined with goniosynechialysis if necessary. Visual acuity, intraocular pressure(IOP), the central anterior chamber depth(ACD),anterior chamber volume(ACV)and peripheral anterior chamber angle(ACA)were examined by Pentacam system pre-operatively and 1d, 1wk, 3 and 6mo post-operatively.RESULTS:In both groups, the IOP was significantly decreased after operations(P< 0.01), Which in patients with APACG were 51.17±6.58mmHg and 14.32±2.66mmHg and in patients with CPACG were 33.25±5.45mmHg and 15.86±3.54mmHg. The IOP significantly decreased more in patients with APACG than that in patients with CPACG(PPPPvs 2.83±0.10mm respectively; ACV were 68.34±14.02μm3 vs 145.85±14.36μm3; ACA were 18.28°±4.46° vs 30.50°±4.23°. In patients with CPACG: ACD before and after surgeries were 1.96±0.20mm vs 2.82±0.10mm; ACV were 88.19±15.86μm3 vs 141.28±14.64μm3; ACA were 22.03°±4.48°vs 31.65°±4.62°. Compared to CPACG group, the ACD, ACV and ACA of patients with APACG were significantly lower before operations(PP>0.05). The changes on ACD, ACV and ACA before and after operations were significant between patients with APACG and CPACG(PCONCLUSION:Pentacam system can directly demonstrate the changes of anterior segment before and after phacoemulsification combined with IOL for angle-closure glaucoma. It demonstrates that the anterior segments maybe closely related to the mechanisms of PACG, the changes of which contributes significantly to the clinical effects of phacoemulsification and PC-IOL implantation for both APACG and CPACG patients. The difference of clinical efficacy for APACG and CPACG is maybe correlatied to the different mechanisms.

AIM: To observe the flap characteristics and the factors correlated to the thickness of the cornea flap created with mechanical microkeratome in sub-bowman's keratomileusis(SBK).METHODS: One hundred and ninety-six consecutive eyes of 98 patients were treated with Moria One Use-Plus SBK microkeratome. The intended flap thickness was 100μm. The flap thickness was measured by A type ultrasound. The flap complications were recorded and single variable correlations of the flap thickness and preoperative MRSE, corneal diameter, corneal thickness, corneal keratometric value K were determined. RESULTS: The mean flap thickness was 100.96±5.35μm, mean flap thickness was 103.56±5.22μm in the left eyes and 98.12±5.50μm in the right eyes, the difference between right and left eyes was statistically significant(t=2.36, PF=0.438,P>0.05). Corneal flap thickness was positively correlated with preoperative corneal keratometric value K(r=0.452, Pr=0.312, PCONCLUSION: The corneal flaps created by mechanical microkeratome in SBK have even thickness, good predictability and fewer complications, and are positively correlated with preoperative corneal keratometric value K and preoperative central corneal thickness.