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The work is based on a comparison of data gained in experiments with the results of clinical examination of a large group of patients in the late-term period after endovascular occlusion of a patent ductus arteriosus (PDA). The regular features of the course of the morphological process in the zone of the PDA after implantation of a botallo-occluder into it were studied. Clinico-morphological parallels were made. The high efficacy and reliability of the new method of endovascular treatment of PDA, developed at the Moscow Second Medical institute, was substantiated morphologically and confirmed clinically.

Experiments were conducted for comparative analysis of the use of elastic (Spandex) and nonelastic (Eticon) threads for the formation of anastomoses in vascular surgery. The results were studied in follow-up periods of up to 18 months. Thrombosis occurred at the site of anastomosis only in 6.8% of cases in which elastic threads were applied in contrast to 30% of cases in which nonelastic threads were used. Microscopy in the first case revealed neither marked inflammatory reaction nor necroses, which promoted regeneration and the formation of the neointima. In the second case, on the one hand, the nonelastic anastomosis between two elastic tubes creates conditions for thrombus formation, and on the other, the tension occurring periodically in this zone causes damage to the tissues and prevents rapid formation of the neointima.

The "Plasma scalpel CP-M" device was used in experiments on dogs to study the possibility of applying plasma irradiation in the surgery of the lungs. The morphology of their "plasma wound" and reparative processes was studied. The plasma device was employed in the clinic in 40 various operations on the lungs and thoracic wall for cleansing the pleural cavity and operative wound, hemostasis from the walls of the pleural cavity, and hermetic closure of the lung wound surface. It was established that the plasma scalpel can be used effectively in hermetic closure of defects in the pulmonary tissue and cleansing of the pleural cavity and operative wound; for arresting diffuse bleeding from the walls of the pleural cavity, the plasma scalpel may be used only in combination with other methods of hemostasis.