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Start Over Author "Marco W. Fraaije" Journal green chemistry
2 results on '"Marco W. Fraaije"'

1. From waste to value - direct utilization of limonene from orange peel in a biocatalytic cascade reaction towards chiral carvolactone

Author

Nikolin Oberleitner, Florian Rudroff, Peter Gaertner, Marco W. Fraaije, Katharina Bica, Marko D. Mihovilovic, Anna K. Ressmann, Uwe T. Bornscheuer, and Biotechnology

Subjects
EXTRACTION, Chemical substance, STYRENE, Orange (colour), 010402 general chemistry, 01 natural sciences, Styrene, LIQUID BUFFER SYSTEMS, chemistry.chemical_compound, Cascade reaction, Environmental Chemistry, Organic chemistry, Dissolution, Limonene, 010405 organic chemistry, Chemistry, Water extraction, DNA, Pollution, 0104 chemical sciences, Chemical engineering, Cascade, IONIC LIQUIDS, ESCHERICHIA-COLI, CELLS, BIOTRANSFORMATION
Abstract

In this proof of concept study we demonstrate direct utilization of limonene containing waste product orange peel as starting material for a biocatalytic cascade reaction. The product of this cascade is chiral carvolactone, a promising building block for thermoplastic polymers. Four different concepts were applied to augment limonene availability based on either water extraction solely, addition of extraction enhancers or biomass dissolution.

Published
2017

2. Ionic liquids for enhancing the enantioselectivity of isolated BVMO-catalysed oxidationsElectronic supplementary information (ESI) available: Complete experimental procedures and chromatographic data. See DOI: 10.1039/c0gc00560fWe would like to dedicate this paper to Prof. Antonio García Martínez on the occasion of his retirement.

Author

Cristina Rodríguez, Gonzalo de Gonzalo, Marco W. Fraaije, and Vicente Gotor

Subjects
IONIC liquids, ENANTIOSELECTIVE catalysis, OXIDATION, STRAIN theory (Chemistry), MONOOXYGENASES, STABILITY (Mechanics), ENZYMES
Abstract

The present study describes the first-time usage of an isolated thermostable Baeyer–Villiger monooxygenase (phenylacetone monooxygenase, PAMO) in the presence of ionic liquids. The stability, activity and selectivity of PAMO as an oxidative enzyme in the presence of different ionic liquids were studied. This revealed that the addition of some specific ionic liquids, such Ammoeng™ 102 and [bmim]MeSO4, can significantly enhance the E-value in the oxidation of racemic benzylketones. Moreover, the use of ionic liquids increases the optimal substrate concentration for performing Baeyer–Villiger oxidation, thereby extending the biocatalytic repertoire of PAMO for synthetic applications. [ABSTRACT FROM AUTHOR]

Published
2010

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