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The introduction of lubricity protection as part of the EN 590 diesel specification in Europe has led to the wide-spread use of lubricity additives as a cost effective means to achieve the required level of performance. At the moment there are a number of different lubricity additive chemistries available to refiners and some discussion as to the merits of the different products. During the initial introduction of lubricity additives for low sulphur diesel fuel certain chemistries were found to have negative interactions that led to field issues. These products were mainly acid based and found to interact with basic components present both in the fuel and in the lubricant. These issues led to a move to neutral lubricity additives being favoured in preference to products based on acidic chemistry. However, even some of the neutral chemistries were found to have negative harm effects. In this paper we will discuss how the development of no harm testing of refinery additives has led to the safe use of both neutral and acidic lubricity additives. The well-established DGMK test protocol allows refiners to select the most cost effective lubricity additive based upon extensive no harm testing in preference to selection being based upon generic chemistry. [ABSTRACT FROM AUTHOR]