1. Common sialylated glycan in Actinobacillus suis.
- Author
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Deutschmann, Rudolf, Boncheff, Alexander G., Daraban, Loredana, MacInnes, Janet I., and Monteiro, Mario A.
- Subjects
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OLIGOSACCHARIDES , *ACTINOBACILLUS , *SIALIC acids , *CARBOHYDRATES , *PASTEURELLACEAE - Abstract
A sialylated oligosaccharide was identified in four representative strains of the Gram-negative swine pathogen, Actinobacillus suis. As characterized, the glycan consists of a free oligosaccharide with a N-acetyl-lactosamine-like backbone decorated with sialic acid, phosphoethanolamine (PEA) and O-acetyl units: 9-O-Ac-Neu5Ac-(2→6)-β-d-Galp-(1→4)-β-d-6-O-Ac-GlcpNAc-(1→3)-[PEA→6]-β-d-Galp-(1→3)-β-d-GlcpNAc-(1→2)-[9-O-Ac-Neu5Ac-(2→6)]-β-d-Galp-(1→4)-β-d-6-O-Ac-GlcpNAc-(1→3)-[PEA→6]-β-d-Galp-(1→3)-d-GlcpNAc. The ubiquitous expression of this sialylated glycan suggests that this carbohydrate may play an important role in the survival of A. suis in the host. [ABSTRACT FROM PUBLISHER]
- Published
- 2010
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