1. [Comparative evaluation of the safety of poly- and and oligoguanidines].
- Author
-
Timofeeva MIu, Matiushina GP, Krasniuk II, Rumiantsev GI, Vorob'ev AA, Nesvizhskiĭ IuV, and Bogdanova EA
- Subjects
- Bacteria drug effects, Humans, Anti-Infective Agents adverse effects, Environmental Pollution adverse effects, Guanidine adverse effects
- Abstract
The antimicrobial activity and microenvironmental safety of poly- and oligoguanidine antiseptics were compared. E. coli and St. aureus test strains were found to be more sensitive to chlorohexidine bigluconate (CHB) upon a long (24 hour) exposure and to polyhexamethylene guanidine derivatives on short (30-second) contact. It is concluded that unlike polyguanidine antiseptics, CHB is more ecologically dangerous; when used for rapid disinfection, it can provoke impairment in the microenvironmental balance outside the area of application. The findings show it expedient to assess the microenvironmental safety of antimicrobial agents in order to prevent ecological catastrophes.
- Published
- 2006