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Accurate hydrologic modeling is vital to characterizing how the terrestrial water cycle responds to climate change. Pure deep learning (DL) models have been shown to outperform process-based ones while remaining difficult to interpret. More recently, differentiable physics-informed machine learning models with a physical backbone can systematically integrate physical equations and DL, predicting untrained variables and processes with high performance. However, it is unclear if such models are competitive for global-scale applications with a simple backbone. Therefore, we use – for the first time at this scale – differentiable hydrologic models (full name δ HBV-globe1.0-hydroDL, shortened to δ HBV here) to simulate the rainfall–runoff processes for 3753 basins around the world. Moreover, we compare the δ HBV models to a purely data-driven long short-term memory (LSTM) model to examine their strengths and limitations. Both LSTM and the δ HBV models provide competitive daily hydrologic simulation capabilities in global basins, with median Kling–Gupta efficiency values close to or higher than 0.7 (and 0.78 with LSTM for a subset of 1675 basins with long-term discharge records), significantly outperforming traditional models. Moreover, regionalized differentiable models demonstrated stronger spatial generalization ability (median KGE 0.64) than a traditional parameter regionalization approach (median KGE 0.46) and even LSTM for ungauged region tests across continents. Nevertheless, relative to LSTM, the differentiable model was hampered by structural deficiencies for cold or polar regions, highly arid regions, and basins with significant human impacts. This study also sets the benchmark for hydrologic estimates around the world and builds a foundation for improving global hydrologic simulations. [ABSTRACT FROM AUTHOR]