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This study focuses on integration processes in European Research and Development ( R&D) by analyzing the spatiotemporal dimension of three different R&D collaboration networks across Europe. The studied networks cover different types of knowledge creation, namely project-based R&D networks within the European Union ( EU) Framework Programmes ( FPs), co-patent networks, and co-publication networks. Integration in European R&D-one of the main pillars of the EU Science Technology and Innovation policy-refers to the harmonization of fragmented national research systems across Europe and to the free movement of knowledge and researchers. The objective is to describe and compare spatiotemporal patterns at a regional level and to estimate the evolution of separation effects over the time period 1999-2006 that influence the probability of cross-region collaborations in the distinct networks under consideration. The study adopts a spatial interaction modeling perspective, econometrically specifying a panel generalized linear model relationship, taking into account spatial autocorrelation among flows using eigenfunction spatial filtering methods. The results show that geographical factors are a lower hurdle for R&D collaborations in the FP networks than in co-patent networks and co-publication networks. Furthermore, it is shown that the geographical integration is higher in the FP network. [ABSTRACT FROM AUTHOR]