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Start Over Descriptor "copy-number" Journal genomics data
2 results on '"copy-number"'

1. Multi-omic profiling of MYCN-amplified neuroblastoma cell-lines

Author

Erik Dassi, Valentina Greco, Viktoryia Sidarovich, Paola Zuccotti, Natalia Arseni, Paola Scaruffi, Gian Paolo Tonini, and Alessandro Quattrone

Subjects
Neuroblastoma, Copy-number, Translatome, Transcriptome, MiRome, Genetics, QH426-470
Abstract

Neuroblastoma is the most common pediatric cancer, arising from the neural crest cells of the sympathetic nervous system. Its most aggressive subtype, characterized by the amplification of the MYCN oncogene, has a dismal prognosis and no effective treatment is available. Understanding the alterations induced by the tumor on the various layers of gene expression is therefore important for a complete characterization of this neuroblastoma subtype and for the discovery of new therapeutic opportunities. Here we describe the profiling of 13 MYCN-amplified neuroblastoma cell lines at the genome (copy number), transcriptome, translatome and miRome levels (GEO series GSE56654, GSE56552 and GSE56655). We provide detailed experimental and data analysis procedures by means of which we derived the results described in [1].

Published
2015
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2. Multi-omic profiling of MYCN-amplified neuroblastoma cell-lines

Author

Gian Paolo Tonini, Natalia Arseni, Erik Dassi, Paola Scaruffi, Viktoryia Sidarovich, Alessandro Quattrone, Valentina Greco, and Paola Zuccotti

Subjects
Copy-number, lcsh:QH426-470, Biology, Bioinformatics, Biochemistry, Genome, Translatome, Transcriptome, Neuroblastoma cell, Neuroblastoma, MiRome, Gene expression, Data in Brief, Genetics, medicine, neoplasms, Neural crest, Omics, medicine.disease, Pediatric cancer, lcsh:Genetics, Cancer research, Molecular Medicine, Biotechnology
Abstract

Neuroblastoma is the most common pediatric cancer, arising from the neural crest cells of the sympathetic nervous system. Its most aggressive subtype, characterized by the amplification of the MYCN oncogene, has a dismal prognosis and no effective treatment is available. Understanding the alterations induced by the tumor on the various layers of gene expression is therefore important for a complete characterization of this neuroblastoma subtype and for the discovery of new therapeutic opportunities. Here we describe the profiling of 13 MYCN-amplified neuroblastoma cell lines at the genome (copy number), transcriptome, translatome and miRome levels (GEO series GSE56654, GSE56552 and GSE56655). We provide detailed experimental and data analysis procedures by means of which we derived the results described in [1].

Published
2015

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