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A recent study conducted at the Armed Forces Medical College in Maharashtra, India, focused on the association between iron deficiency and thyroid dysfunction in male patients with androgenetic alopecia (AGA). The study compared serum ferritin and thyroid-stimulating hormone levels in 30 male patients with AGA and age-matched healthy controls. The research found no statistically significant difference in the levels of serum ferritin and thyroid-stimulating hormone between the cases and controls, indicating an insignificant association between AGA, iron deficiency, and thyroid dysfunction. [Extracted from the article]

Researchers from Seoul National University have conducted a study on alopecia areata, focusing on the use of a humanized CXCL12 antibody for treatment. The study found that the antibody delayed the onset of alopecia areata in mice and modulated the immune response. Through single-cell RNA sequencing, the researchers identified key immune cell-related genes affected by the antibody treatment. This research suggests that the humanized CXCL12 antibody shows promise for treating alopecia areata by modulating the immune system. [Extracted from the article]

A recent report from researchers in Warsaw, Poland discusses the use of mRNA analysis to differentiate between skin biopsies from patients with atopic dermatitis (AD) and psoriasis vulgaris (PV). The study aimed to develop a diagnostic tool to accurately distinguish between these chronic inflammatory diseases. The researchers found that the analysis of human beta defensin-2 (hBD-2) mRNA and proteasome subunit b type 8 (PSMB8) mRNA were the most valuable parameters in differentiating AD and PV biopsies. This research provides valuable insights into the diagnosis and understanding of these skin conditions. [Extracted from the article]

A recent study conducted by the University of Bonn in Germany has identified a genetic variant associated with autosomal dominant monilethrix, a rare hereditary hair disorder characterized by a beaded hair shaft structure and increased hair fragility. The study found that a nonsense variant in the KRT31 gene was responsible for the condition in affected individuals from four unrelated families. The variant led to the alteration of keratin 31 protein, affecting its expression, subcellular localization, and formation of vesicular-like structures in the cell cytoplasm. This research contributes to a better understanding of the genetic basis of monilethrix and may improve molecular diagnostics for similar hair and nail disorders. [Extracted from the article]

A recent report discusses research findings on alpha 1-antitrypsin deficiency, a condition that affects the lungs and liver. The study focuses on a family with rare alleles of the SERPINA1 gene, which are associated with the deficiency. The index case, a 51-year-old female, presented with respiratory symptoms and genetic testing revealed a PiZ/p.(Phe76del) genotype. The researchers emphasize the importance of early detection and intervention to improve quality of life and outcomes for individuals with this condition. The study was conducted in Regensburg, Germany and funded by Grifols Sa. [Extracted from the article]

Researchers at the University Hospital Bonn and the University of Bonn have identified a new gene, KRT31, that is responsible for a rare congenital form of hair loss called monilethrix. This condition, which usually begins in infancy, causes extreme variability in the degree of hair loss within affected families. The researchers found a stop mutation in the KRT31 gene, which leads to the premature termination of protein synthesis and impairs the function of the protein. The inclusion of KRT31 in diagnostic gene panels for hair, skin, and nail diseases is expected to improve diagnostics for those affected by hair loss. [Extracted from the article]

A recent report from the Instituto de Biomedicina de Valencia (IBV-CSIC) discusses the role of glucocorticoid receptors (GR) in atopic dermatitis (AD) inflammation. The study found that defective local GR signaling may contribute to AD pathology. The researchers identified 145 proteins that interact with GR in keratinocytes, including epidermal transcription factors involved in AD. Treatment with dexamethasone, a synthetic glucocorticoid, counteracted the up-regulation of inflammatory markers associated with AD. The study suggests that GR loss plays a causative role in AD pathogenesis through interactions with P63 and autocrine signaling in epidermal keratinocytes. [Extracted from the article]

Researchers from Kyushu University Hospital in Japan have conducted a study on the effectiveness of difamilast, a phosphodiesterase 4 (PDE4) inhibitor, in treating atopic dermatitis (AD). The study found that difamilast increased the production of soluble ST2 (sST2), a decoy receptor that suppresses IL-33 signal transduction, without affecting the expression of the transmembrane ST2 receptor (ST2L). The researchers also discovered that difamilast activated the aryl hydrocarbon receptor (AHR)-nuclear factor erythroid 2-related factor 2 (NRF2) axis, and the knockdown of AHR or NRF2 abolished the production of sST2. These findings suggest that difamilast improves AD symptoms by inhibiting IL-33 activity. [Extracted from the article]

A new report from the Medical University of Vienna in Austria presents findings on the prevalence and clinical correlates of skin disease in patients with systemic lupus erythematosus (SLE). The study reviewed records of 335 SLE patients and found that 24.7% had lupus-specific skin conditions, 44.2% had lupus-nonspecific conditions, and 31.2% had both. The presence of lupus skin disease was associated with photosensitivity and specific antibodies, while patients without skin disease more commonly had elevated C-reactive protein levels. The study concluded that lupus skin disease does not significantly impact the severity of SLE or overall survival. [Extracted from the article]

A recent study conducted by Queen Mary University of London provides new insights into junctional epidermolysis bullosa (JEB), a severe form of epidermolysis bullosa (EB). JEB is characterized by extreme skin and mucosal fragility and is caused by mutations in genes encoding skin basement membrane proteins. The study utilized a mouse model to investigate the molecular and cellular differences in JEB. The researchers identified changes in cellular pathways and disease-specific signaling pathways that could potentially be targeted for therapeutic treatment of JEB. [Extracted from the article]

Researchers at Tekirdag Namik Kemal University have published a study on the association between Pityriasis Rosea (PR) and human herpesvirus 6 (HHV-6) and human herpesvirus 7 (HHV-7) infections. The study aimed to clarify the etiology of PR by examining tissue and plasma samples using molecular methods and evaluating the results with serological parameters. The results showed that HHV-6 and HHV-7 were present in PR patients, supporting their role in the etiology of PR. The researchers recommend using different biological materials simultaneously and calibrated quantitative real-time polymerase chain reaction (CQ RT-PCR) as a diagnostic technique to clarify the etiology of PR and avoid confusion. [Extracted from the article]

Researchers from the University of Bari in Italy have conducted a study on atopic dermatitis, a chronic inflammatory skin condition. The study focuses on the role of suppressors of cytokine signaling (SOCS) proteins in regulating inflammatory responses in the skin. The researchers found that SOCS proteins are dysregulated in inflammatory skin diseases such as psoriasis and atopic dermatitis. This research provides valuable insights into the pathogenesis of these conditions and may contribute to the development of new treatments. [Extracted from the article]

A recent study conducted by researchers at the University of Babylon aimed to evaluate the levels of interleukin-4 and interleukin-25 in the serum of eczema patients. Eczema is an inflammatory skin disease that can be caused by environmental, genetic, and immune factors. The study found that patients with eczema had significantly higher levels of interleukin-4 and interleukin-25 in their serum compared to the control group. These findings contribute to a better understanding of the immune pathogenesis of eczema. [Extracted from the article]

A recent study from Shanghai Jiao Tong University School of Medicine explores the role of the aryl hydrocarbon receptor (AhR) in vitiligo, an acquired autoimmune dermatosis characterized by patchy skin depigmentation. The research suggests that the AhR signaling pathway is downregulated in vitiligo, and activation of this pathway can help protect melanocytes from oxidative stress damage, control disease progression, and promote repigmentation. The study reviews the relevant literature and provides new potential therapeutic strategies for vitiligo treatment. Further information can be obtained from the Department of Dermatology at Shanghai General Hospital. [Extracted from the article]

A new study conducted by researchers at Southern Medical University explores the inter-relationships between galectin-3 (Gal-3), the NLR family pyrin domain containing 3 (NLRP3) inflammasome, and oral lichen planus (OLP). The study analyzed oral biopsy specimens from 30 patients with erosive OLP and 30 healthy controls. The results showed that patients with erosive OLP had higher levels of Gal-3 and NLRP3 inflammasome compared to the control group. Additionally, there was a positive correlation between Gal-3 and NLRP3 inflammasome. This research provides preliminary insights into the potential role of Gal-3 and NLRP3 inflammasome in OLP. [Extracted from the article]

Scientists at Massachusetts General Hospital have made progress in understanding the formation of aplasia cutis congenita (ACC), a rare congenital scalp defect. The researchers found that mutations in the KCTD1 and KCTD15 genes lead to the impairment of certain cells that are part of the midline cranial sutures, which normally express growth factors that induce skin formation over the skull. The study, published in The Journal of Clinical Investigation, also revealed the important roles of these proteins in the formation of skin appendages. The findings may help develop strategies to target the anomalies associated with ACC, but further research is needed to understand the molecular mechanisms involved. [Extracted from the article]

A new study conducted by researchers at Copenhagen University Hospital Herlev and Gentofte explores the role of proteins in psoriasis, a skin disease characterized by inflammation and structural changes. The study reviewed 772 proteomic studies published between 1996 and 2023, identifying 30 studies that met the inclusion criteria. The findings suggest that proteins play a central role in the pathological mechanisms of psoriasis, with certain proteins consistently upregulated or downregulated in skin and blood samples from patients. The study also highlights the presence of previously unexplored proteins that may warrant further investigation. [Extracted from the article]

A recent study conducted by researchers at Hisamitsu Pharmaceutical Co. Inc. in Ibaraki, Japan, explored the use of non-invasive microneedle application to improve skin barrier function and moisturizing function. The researchers found that microneedle application increased the gene expression of certain proteins involved in skin health and increased the production of ceramide, a natural moisturizing factor. These findings suggest that non-invasive microneedle application may be a safe and effective method for improving skin health. The research has been peer-reviewed and published in the Biological and Pharmaceutical Bulletin. [Extracted from the article]

Atopic Dermatitis, Biological Factors, Chemokine Receptors, Chemokines, Cytokine Receptors, Chemotactic Factors, Cytokines, Dermatitis, Dermatology, G-Protein-Coupled Receptors, Health and Medicine, Immunology, Inflammation Mediators, Intercellular Signaling Peptides and Proteins, Membrane Proteins, Skin Diseases and Conditions, Skin and Connective Tissue Diseases and Conditions Keywords: Atopic Dermatitis; Biological Factors; Chemokine Receptors; Chemokines; Chemotactic Factors; Cytokine Receptors; Cytokines; Dermatitis; Dermatology; G-Protein-Coupled Receptors; Health and Medicine; Immunology; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions EN Atopic Dermatitis Biological Factors Chemokine Receptors Chemokines Chemotactic Factors Cytokine Receptors Cytokines Dermatitis Dermatology G-Protein-Coupled Receptors Health and Medicine Immunology Inflammation Mediators Intercellular Signaling Peptides and Proteins Membrane Proteins Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions 698 698 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on atopic dermatitis is now available. Keywords for this news article include: Functional Biomaterial Research Center, Immunology, Dermatology, Atopic Dermatitis, Membrane Proteins, Biological Factors, Cytokine Receptors, Chemokine Receptors, Chemotactic Factors, Health and Medicine, Inflammation Mediators, G-Protein-Coupled Receptors, Skin Diseases and Conditions, Intercellular Signaling Peptides and Proteins. [Extracted from the article]

Ottawa, Canada, North and Central America, Amino Acids, Aromatic Amino Acids, Enzymes and Coenzymes, Health and Medicine, Kinase, Mastocytosis, Proteins, Proteomics, Skin Diseases and Conditions, Skin and Connective Tissue Diseases and Conditions, Tyrosine, Tyrosine Kinase Keywords: Ottawa; Canada; North and Central America; Amino Acids; Aromatic Amino Acids; Enzymes and Coenzymes; Health and Medicine; Kinase; Mastocytosis; Proteins; Proteomics; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions; Tyrosine; Tyrosine Kinase EN Ottawa Canada North and Central America Amino Acids Aromatic Amino Acids Enzymes and Coenzymes Health and Medicine Kinase Mastocytosis Proteins Proteomics Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions Tyrosine Tyrosine Kinase 1616 1616 1 10/03/23 20231006 NES 231006 2023 OCT 6 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on Skin Diseases and Conditions - Mastocytosis have been presented. [Extracted from the article]

Congenital Abnormalities, Dermatology, Epidermolysis Bullosa, Extracellular Matrix Proteins, Genetic Skin Diseases and Conditions, Genetics, Health and Medicine, Laminin, Membrane Glycoproteins, Junctional Epidermolysis Bullosa, Membrane Proteins, Skin Diseases and Conditions, Vesiculobullous Skin Diseases and Conditions, Skin Abnormalities Keywords: Congenital Abnormalities; Dermatology; Epidermolysis Bullosa; Extracellular Matrix Proteins; Genetic Skin Diseases and Conditions; Genetics; Health and Medicine; Junctional Epidermolysis Bullosa; Laminin; Membrane Glycoproteins; Membrane Proteins; Skin Abnormalities; Skin Diseases and Conditions; Vesiculobullous Skin Diseases and Conditions EN Congenital Abnormalities Dermatology Epidermolysis Bullosa Extracellular Matrix Proteins Genetic Skin Diseases and Conditions Genetics Health and Medicine Junctional Epidermolysis Bullosa Laminin Membrane Glycoproteins Membrane Proteins Skin Abnormalities Skin Diseases and Conditions Vesiculobullous Skin Diseases and Conditions 972 972 1 07/24/23 20230728 NES 230728 2023 JUL 28 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on junctional epidermolysis bullosa. [Extracted from the article]

Keywords: Al Kharj; Saudi Arabia; Asia; Allergic Contact Dermatitis; Allergies; Allergy Research; Caspase; DNA-Binding Proteins; Dermatitis; Dermatology; Enzymes and Coenzymes; Health and Medicine; Immune System Diseases and Conditions; Inflammation; NF-kappa B; Nuclear Proteins; Proteins; Pyroptosis; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions; Transcription Factors EN Al Kharj Saudi Arabia Asia Allergic Contact Dermatitis Allergies Allergy Research Caspase DNA-Binding Proteins Dermatitis Dermatology Enzymes and Coenzymes Health and Medicine Immune System Diseases and Conditions Inflammation NF-kappa B Nuclear Proteins Proteins Pyroptosis Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions Transcription Factors 863 863 1 06/19/23 20230623 NES 230623 2023 JUN 23 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on Immune System Diseases and Conditions - Allergic Contact Dermatitis have been presented. Al Kharj, Saudi Arabia, Asia, Allergic Contact Dermatitis, Allergies, Allergy Research, Caspase, DNA-Binding Proteins, Dermatitis, Dermatology, Enzymes and Coenzymes, Health and Medicine, Immune System Diseases and Conditions, Inflammation, NF-kappa B, Nuclear Proteins, Proteins, Pyroptosis, Skin Diseases and Conditions, Skin and Connective Tissue Diseases and Conditions, Transcription Factors. [Extracted from the article]

Keywords: Hangzhou; People's Republic of China; Asia; Apoptosis Regulatory Proteins; Caspase; Dermatology; Enzymes and Coenzymes; Health and Medicine; Initiator Caspases; Intracellular Signaling Peptides and Proteins; Papulosquamous Skin Diseases and Conditions; Peptides; Psoriasis; Skin Diseases and Conditions EN Hangzhou People's Republic of China Asia Apoptosis Regulatory Proteins Caspase Dermatology Enzymes and Coenzymes Health and Medicine Initiator Caspases Intracellular Signaling Peptides and Proteins Papulosquamous Skin Diseases and Conditions Peptides Psoriasis Skin Diseases and Conditions 601 601 1 06/05/23 20230609 NES 230609 2023 JUN 9 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on Skin Diseases and Conditions - Psoriasis have been presented. Hangzhou, People's Republic of China, Asia, Caspase, Dermatology, Enzymes and Coenzymes, Health and Medicine, Initiator Caspases, Intracellular Signaling Peptides and Proteins, Papulosquamous Skin Diseases and Conditions, Peptides, Psoriasis, Skin Diseases and Conditions, Apoptosis Regulatory Proteins. [Extracted from the article]

Genetics, Hair Diseases and Conditions, Health and Medicine, Hypotrichosis, Ribosomal Proteins, Skin Diseases and Conditions Keywords: Genetics; Hair Diseases and Conditions; Health and Medicine; Hypotrichosis; Ribosomal Proteins; Skin Diseases and Conditions EN Genetics Hair Diseases and Conditions Health and Medicine Hypotrichosis Ribosomal Proteins Skin Diseases and Conditions 1362 1362 1 04/03/23 20230407 NES 230407 2023 APR 7 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Current study results on hypotrichosis have been published. [Extracted from the article]

Keywords: Cytokines; Health and Medicine; Inflammation; Intercellular Signaling Peptides and Proteins; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions EN Cytokines Health and Medicine Inflammation Intercellular Signaling Peptides and Proteins Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions 2023 MAR 10 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on skin diseases and conditions is now available. Cytokines, Health and Medicine, Inflammation, Intercellular Signaling Peptides and Proteins, Skin Diseases and Conditions, Skin and Connective Tissue Diseases and Conditions. [Extracted from the article]

Keywords: Atopic Dermatitis; Cytokines; Dermatitis; Dermatology; Health and Medicine; Inflammation; Intercellular Signaling Peptides and Proteins; Membrane Proteins; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions; Tumor Necrosis Factors EN Atopic Dermatitis Cytokines Dermatitis Dermatology Health and Medicine Inflammation Intercellular Signaling Peptides and Proteins Membrane Proteins Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions Tumor Necrosis Factors 2023 MAR 3 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on atopic dermatitis. To elucidate the association of TL1A in AD, we measured the serum TL1A levels in AD patients and healthy controls and performed the immunohistochemistry of TL1A. [Extracted from the article]