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A recent study conducted at the First Affiliated Hospital of Guangxi Medical University in China explored the role of C-C chemokine receptor type 2-positive (CCR2+) macrophages in rheumatic heart disease (RHD). RHD is an autoimmune disease caused by recurrent infections of Group A streptococcus (GAS) that leads to inflammation and fibrosis of heart valves. The study found that CCR2+ macrophages are involved in the valvular remodeling process of RHD. Inhibiting the CCL2/CCR2 signaling pathway may be a potential therapeutic strategy to reduce valve fibrosis in RHD. [Extracted from the article]

A recent study conducted by researchers at the First Affiliated Hospital of Anhui University of Chinese Medicine explored the mechanism of Taohong Siwu Decoction (THSWD) for the treatment of ischemic stroke. THSWD is a traditional Chinese herbal prescription that has shown effectiveness in treating ischemic stroke. The study used bioinformatics analysis, in vitro and in vivo experiments to investigate the mechanism of action of THSWD. The results indicated that THSWD may play a protective role in ischemic stroke by inhibiting the CCL2/CCR2 axis, reducing macrophage infiltration, promoting the polarization of M2 macrophages, and protecting the blood-brain barrier. [Extracted from the article]

A study conducted at the University of Leipzig in Germany explores the role of glutaminyl cyclase (QC) in brain ischemia, a condition characterized by reduced blood flow to the brain. The researchers found that QC expression increased in the infarct area of mice after ischemia, suggesting its involvement in inflammatory processes in the stroke-affected brain. The study also observed an increase in the chemokine CCL2, which is known to contribute to inflammation in neurodegenerative conditions. These findings provide insights into the molecular and cellular responses to brain ischemia and highlight the potential role of QC in inflammatory pathways. [Extracted from the article]

A recent study published in the International Journal of Molecular Sciences explores the role of Toll-like receptor 7 (TLR7) in the immune response induced by the rabies virus (RABV). The study found that different strains of RABV significantly increased the production of chemokines CCL2 and CXCL10, as well as the cytokine IL-6. Blocking TLR7 reduced the expression of these immune factors. Additionally, the study demonstrated that RABV-induced expression of CCL2, CXCL10, and IL-6 involves the Myd88 and NF-kB signaling pathways via the TLR7 signal. This research provides valuable insights into the mechanisms of the immune response to RABV infection. [Extracted from the article]

A recent study conducted at Tongji University in Shanghai, China, explored the relationship between chronic pelvic pain (CPP) and changes in the central nervous system. The researchers established a rat model of CPP and observed higher levels of chemokine ligand 2 (CCL2) in the serum exosomes, pelvic vascular endothelial cells, and cerebrospinal fluid of the CPP group compared to the control group. They also found that CCL2 can activate the Notch2 signaling pathway, suggesting its role in the central sensitization of chronic pelvic pain. This research provides valuable insights into the understanding and potential treatment of CPP. [Extracted from the article]

A recent study conducted by researchers at the Institute for Clinical Research in Kagoshima, Japan, has investigated the effects of eicosapentaenoic acid (EPA) on vascular endothelial growth factor (VEGF)-induced inflammation in human vascular endothelial cells. The study found that VEGF induces the expression of proinflammatory cytokines and chemokines, including monocyte chemoattractant protein-1 (MCP-1), interleukin-6 (IL-6), and interleukin-8 (IL-8), through the activation of specific signaling pathways. However, treatment with EPA was shown to inhibit the expression of these inflammatory molecules by suppressing these signaling pathways. These findings suggest that EPA may have potential as an anti-inflammatory and anti-atherogenic drug. [Extracted from the article]

A recent study conducted at the First Affiliated Hospital of Xi'an Jiao Tong University explores the role of interleukin-6 (IL-6) in immune-mediated necrotizing myopathy (IMNM). IMNM is characterized by muscle fiber necrosis, regeneration, and inflammation. The study found that monocyte chemoattractant protein-1 (MCP-1), a chemokine that regulates monocyte/macrophage infiltration, is expressed in the muscles of IMNM patients. Serum levels of MCP-1, IL-6, and the soluble form of the IL-6 receptor (sIL-6R) were elevated in IMNM patients, and MCP-1 expression was induced by IL-6 signaling through the STAT3 pathway. The researchers concluded that IL-6 trans-signaling may contribute to the immunopathogenesis of IMNM by increasing inflammation through the regulation of MCP-1 expression. [Extracted from the article]

A recent study conducted by researchers at the Department of Cell Biology has explored the potential therapeutic targets for amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. The study focused on the role of glial cells in ALS and examined the effects of astrocyte-targeted treatments on reducing glial activation and neuron pathology. The researchers found that increasing interleukin 10 (IL-10) and reducing C-C motif chemokine ligand 2 (CCL2) signaling in astrocytes resulted in anti-inflammatory effects and reduced neurotoxicity. These findings suggest that IL-10 and CCL2 could be potential therapeutic targets for ALS. [Extracted from the article]

Basal Ganglia Diseases and Conditions, Biological Factors, Brain Diseases and Conditions, CC Chemokines, Central Nervous System Diseases and Conditions, Chemokine CCL5, Cytokines, Genetics, Health and Medicine, Intercellular Signaling Peptides and Proteins, Movement Disorders, Nervous System Diseases and Conditions, Neurodegenerative Diseases and Conditions, Neuroinflammation, Parkinson's Disease, Parkinsonian Disorders, Peptides, Proteins Keywords: Basal Ganglia Diseases and Conditions; Biological Factors; Brain Diseases and Conditions; CC Chemokines; Central Nervous System Diseases and Conditions; Chemokine CCL5; Cytokines; Genetics; Health and Medicine; Intercellular Signaling Peptides and Proteins; Movement Disorders; Nervous System Diseases and Conditions; Neurodegenerative Diseases and Conditions; Neuroinflammation; Parkinson's Disease; Parkinsonian Disorders; Peptides; Proteins EN Basal Ganglia Diseases and Conditions Biological Factors Brain Diseases and Conditions CC Chemokines Central Nervous System Diseases and Conditions Chemokine CCL5 Cytokines Genetics Health and Medicine Intercellular Signaling Peptides and Proteins Movement Disorders Nervous System Diseases and Conditions Neurodegenerative Diseases and Conditions Neuroinflammation Parkinson's Disease Parkinsonian Disorders Peptides Proteins 1532 1532 1 10/09/23 20231013 NES 231013 2023 OCT 13 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on Parkinson's disease. [Extracted from the article]

Keywords: Antibodies; Biological Factors; Blood Proteins; CC Chemokines; Cells; Chemokine CCL2; Chemokines; Chemotactic Factors; Connective Tissue Cells; Cytokines; Headache; Headache and Migraine; Health and Medicine; Immunoglobulins; Immunology; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Macrophages; Monocyte Chemoattractant Proteins; Mononuclear Phagocyte System; Myeloid Cells; Nervous System Diseases and Conditions; Neurologic Manifestations; Neurology; Neurons; Pain; Phagocytes; Primary Headache Diseases and Conditions; Proteins EN Antibodies Biological Factors Blood Proteins CC Chemokines Cells Chemokine CCL2 Chemokines Chemotactic Factors Connective Tissue Cells Cytokines Headache Headache and Migraine Health and Medicine Immunoglobulins Immunology Inflammation Mediators Intercellular Signaling Peptides and Proteins Macrophages Monocyte Chemoattractant Proteins Mononuclear Phagocyte System Myeloid Cells Nervous System Diseases and Conditions Neurologic Manifestations Neurology Neurons Pain Phagocytes Primary Headache Diseases and Conditions Proteins 1188 1188 1 06/26/23 20230630 NES 230630 2023 JUN 30 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators discuss new findings in headache. Intraperitoneal injection of CCL2 neutralizing antibodies inhibited chronic headache-related behaviors induced by repeated NTG administration and repetitive restraint stress, suggesting that the peripheral CCL2-CCR2 signaling mediates headache chronification. [Extracted from the article]

Biological Factors, CC Chemokines, Chemotactic Factors, Cytokines, Inflammation Mediators, Intercellular Signaling Peptides and Proteins, Monocyte Chemoattractant Proteins, Chemokine CCL2 Keywords: Biological Factors; CC Chemokines; Chemokine CCL2; Chemotactic Factors; Cytokines; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Monocyte Chemoattractant Proteins EN Biological Factors CC Chemokines Chemokine CCL2 Chemotactic Factors Cytokines Inflammation Mediators Intercellular Signaling Peptides and Proteins Monocyte Chemoattractant Proteins 2023 FEB 10 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- A new study on CC chemokines is now available. [Extracted from the article]

Keywords: Biological Factors; CC Chemokines; Chemokine CCL2; Chemotactic Factors; Connective Tissue Cells; Cytokines; Dermatology; Fibroblasts; Genetics; Health and Medicine; Hypopigmentation; Inflammation Mediators; Intercellular Signaling Peptides and Proteins; Monocyte Chemoattractant Proteins; Pigmentation Disorders; Skin Diseases and Conditions; Skin and Connective Tissue Diseases and Conditions; Vitiligo EN Biological Factors CC Chemokines Chemokine CCL2 Chemotactic Factors Connective Tissue Cells Cytokines Dermatology Fibroblasts Genetics Health and Medicine Hypopigmentation Inflammation Mediators Intercellular Signaling Peptides and Proteins Monocyte Chemoattractant Proteins Pigmentation Disorders Skin Diseases and Conditions Skin and Connective Tissue Diseases and Conditions Vitiligo 2023 FEB 10 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Investigators publish new report on vitiligo. Biological Factors, CC Chemokines, Chemokine CCL2, Chemotactic Factors, Connective Tissue Cells, Cytokines, Dermatology, Fibroblasts, Genetics, Health and Medicine, Hypopigmentation, Inflammation Mediators, Intercellular Signaling Peptides and Proteins, Monocyte Chemoattractant Proteins, Pigmentation Disorders, Skin Diseases and Conditions, Skin and Connective Tissue Diseases and Conditions, Vitiligo. [Extracted from the article]