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A study conducted by researchers at the University of Houston explores the biomechanical aspects of neural tube defects (NTDs), which are birth defects affecting the brain and spinal cord. The researchers used optical coherence tomography (OCT) and Brillouin microscopy to examine an NTD murine model and found that the stiffness of neuroepithelial tissues in embryos with a specific genetic mutation was significantly lower than in wild-type embryos. The study suggests that tissue stiffness plays a crucial role in normal neural tube closure and opens up avenues for further research on the mechanobiology of embryonic development. The research was supported by the National Institutes of Health (NIH) in the United States. [Extracted from the article]

A recent study conducted by researchers at Shanxi Medical University in China aimed to explore the molecular regulatory mechanism of neural tube defects (NTDs) induced by retinoic acid (RA) in mouse embryos. The researchers analyzed gene expression trends in mouse embryos during the critical period of neural tube closure and identified differentially expressed genes between the NTD group and the control group. They found that RA intervention caused abnormal cellular activities and stress responses during embryo development, leading to abnormal development and the activation of signaling pathways related to organismal self-protection. The study provides valuable insights into the genetic factors involved in NTDs and their underlying mechanisms. [Extracted from the article]

A study conducted by researchers at Peking University in Beijing, China, explored the association between chromium exposure and the risk of neural tube defects (NTDs) in pregnancy. The study included 408 NTD cases and 593 controls with placentas. The researchers found that high chromium exposure was associated with an increased risk of NTDs in humans. In fetal mice, exposure to chromium trichloride (Cr(III)) increased oxidative stress and apoptosis, leading to NTDs. The study suggests that excessive Cr(III) exposure can induce NTDs by activating the JNK/P38 MAPK signaling pathway. [Extracted from the article]

A study conducted at Texas A&M University investigated the role of the dTYMK gene in neural tube defects (NTDs) in mice. The researchers found that dTYMK is an essential gene in mice and is involved in regulating nucleotide pools. However, heterozygosity of the gene did not cause NTDs in the mice. The study suggests that further reduction in the expression of dTYMK may be necessary to observe developmental anomalies in mice. This research has been peer-reviewed and published in the Archives of Biochemistry and Biophysics. [Extracted from the article]

A recent study published in Human Genetics has identified rare missense variants in the HECTD1 gene that are associated with neural tube defects (NTDs) in humans. NTDs are severe malformations of the central nervous system that result from the failure of neural tube closure. The researchers found five rare HECTD1 missense variants in a Chinese cohort of NTD cases, and functional assays showed that these variants reduced the regulation of extracellular heat shock protein 90 (eHSP90) secretion by HECTD1. This is the first association of HECTD1 sequence variation with NTDs in humans. The study was supported by the NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development. [Extracted from the article]

A recent report from Sichuan University provides new insights into neural tube defects (NTDs), which are congenital malformations of the central nervous system. The study utilized integrated multi-omics analysis to explore the role of neuroinflammation in NTDs and identify potential prenatal diagnostic markers. The researchers found that neuroinflammation is a critical feature of NTDs and identified key genes and pathways involved in regulating NTDs-associated neuroinflammation. Additionally, they identified a set of six potential prenatal diagnostic genes that show promise for the early detection of NTDs. This research contributes to a better understanding of the mechanisms underlying NTDs and offers valuable insights for the development of prenatal diagnostics. [Extracted from the article]

Researchers from Weifang Medical University conducted a study to investigate the correlation between genetic variations in the AXIN2 gene and the development of neural tube defects (NTDs). They analyzed AXIN2 gene variations in muscle tissue samples from 100 fetuses with NTDs and conducted functional studies on three of these variations. The study found that two of the variations (D320V and G545E) resulted in the downregulation of AXIN2 protein expression, potentially leading to abnormal activation of the Wnt signaling pathway and contributing to the development of NTDs. This research provides valuable insights into the genetic factors associated with NTDs. [Extracted from the article]

Keywords: Amino Acids; Birth Defects; Congenital Abnormalities; Genetics; Health and Medicine; Homocysteine; Nervous System Diseases and Conditions; Nervous System Malformations; Neural Tube Defects; Protein Expression; Proteomics; Sulfur Amino Acids EN Amino Acids Birth Defects Congenital Abnormalities Genetics Health and Medicine Homocysteine Nervous System Diseases and Conditions Nervous System Malformations Neural Tube Defects Protein Expression Proteomics Sulfur Amino Acids 1190 1190 1 07/10/23 20230714 NES 230714 2023 JUL 14 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Researchers detail new data in neural tube defects. Amino Acids, Birth Defects, Congenital Abnormalities, Genetics, Health and Medicine, Homocysteine, Nervous System Diseases and Conditions, Nervous System Malformations, Neural Tube Defects, Protein Expression, Proteomics, Sulfur Amino Acids Keywords for this news article include: Capital Institute of Pediatrics, Beijing, People's Republic of China, Asia, Genetics, Proteomics, Homocysteine, Birth Defects, Protein Expression, Sulfur Amino Acids, Health and Medicine, Neural Tube Defects, Congenital Abnormalities, Nervous System Malformations, Nervous System Diseases and Conditions. [Extracted from the article]

The news correspondents obtained a quote from the research from the Department of Hygiene and Public Health, "This study hypothesized that single nucleotide polymorphisms (SNPs) in placental DIOs genes could be related to NTDs. Keywords: Osaka; Japan; Asia; Birth Defects; China; Genetics; Health and Medicine; Nervous System Diseases and Conditions; Nervous System Malformations; Neural Tube Defects EN Osaka Japan Asia Birth Defects China Genetics Health and Medicine Nervous System Diseases and Conditions Nervous System Malformations Neural Tube Defects 1254 1254 1 04/24/23 20230428 NES 230428 2023 APR 28 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Researchers detail new data in Birth Defects - Neural Tube Defects. [Extracted from the article]

Keywords: Anencephaly; Birth Defects; Central Nervous System Diseases and Conditions; Congenital Abnormalities; Genetics; Health and Medicine; Nervous System Diseases and Conditions; Nervous System Malformations; Neural Tube Defects; Severe Teratoid Abnormalities EN Anencephaly Birth Defects Central Nervous System Diseases and Conditions Congenital Abnormalities Genetics Health and Medicine Nervous System Diseases and Conditions Nervous System Malformations Neural Tube Defects Severe Teratoid Abnormalities 1743 1743 1 04/03/23 20230407 NES 230407 2023 APR 7 (NewsRx) -- By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- New research on neural tube defects is the subject of a new report. Anencephaly, Birth Defects, Central Nervous System Diseases and Conditions, Congenital Abnormalities, Genetics, Health and Medicine, Nervous System Diseases and Conditions, Nervous System Malformations, Neural Tube Defects, Severe Teratoid Abnormalities. [Extracted from the article]

Beijing, People's Republic of China, Asia, Genetics, DNA Repair, Proteomics, DNA Research, Birth Defects, Health and Medicine, Neural Tube Defects, Deoxyribonucleic Acid, Congenital Abnormalities, Nervous System Malformations, Nervous System Diseases and Conditions, Capital Institute of Pediatrics Keywords: Capital Institute of Pediatrics; Beijing; People's Republic of China; Asia; Genetics; DNA Repair; Proteomics; DNA Research; Birth Defects; Health and Medicine; Neural Tube Defects; Deoxyribonucleic Acid; Congenital Abnormalities; Nervous System Malformations; Nervous System Diseases and Conditions EN Capital Institute of Pediatrics Beijing People's Republic of China Asia Genetics DNA Repair Proteomics DNA Research Birth Defects Health and Medicine Neural Tube Defects Deoxyribonucleic Acid Congenital Abnormalities Nervous System Malformations Nervous System Diseases and Conditions Fresh data on neural tube defects are presented in a new report. [Extracted from the article]

The article discusses research from the Capital Institute of Pediatrics which described the construction and analysis of long noncoding RNA (lncRNA)-related competing endogenous RNA (ceRNA) network in low folate combined with methotrexate-induced neural tube defects in a mouse model.