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Start Over Author "Chen, Ellson Y." Journal genomics
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7. PLAC1,an Xq26 Gene with Placenta-Specific Expression

Author

Cocchia, Massimo, Huber, Reid, Pantano, Serafino, Chen, Ellson Y., Ma, Peter, Forabosco, Antonino, Ko, Minoru S.H., and Schlessinger, David

Abstract

A novel human X-linked gene shows placenta-specific expression and has been named PLAC1.The gene maps 65 kb telomeric to HPRTat Xq26 and has been completely sequenced at the cDNA and genomic levels. The mouse orthologue Plac1maps to the syntenically equivalent region of the mouse X chromosome. In situhybridization studies with the antisense mRNA during mouse embryogenesis detect Plac1expression from 7.5 dpc (days postcoitum) to 14.5 dpc in ectoplacental cone, giant cells, and labyrinthine trophoblasts. The putative human and murine PLAC1 proteins are 60% identical and 77% homologous. Both include a signal peptide and a peptide sequence also found in an interaction domain of the ZP3 (zona pellucida 3) protein. These results make PLAC1a marker for placental development, with a possible role in the establishment of the mother–fetus interface.

Published
2000
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