1. MicroRNAs miR-221 and miR-222: a new level of regulation in aggressive breast cancer
- Author
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George A. Calin and Maitri Y. Shah
- Subjects
0303 health sciences ,business.industry ,Systems biology ,Medical practice ,Drug resistance ,medicine.disease ,Proteomics ,Bioinformatics ,Research Highlight ,Phenotype ,Human genetics ,3. Good health ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,030220 oncology & carcinogenesis ,microRNA ,Genetics ,Cancer research ,Molecular Medicine ,Medicine ,business ,Molecular Biology ,Genetics (clinical) ,030304 developmental biology - Abstract
MicroRNAs (miRNAs) are crucial in the initiation and progression of tumors. A recent study has reported that the miRNAs miR-221 and miR-222 are involved in the promotion of an aggressive basal-like phenotype in breast cancer, functioning downstream of the RAS pathway and triggering epithelial-to-mesenchymal transition. These new insights into the roles of miR-221/222 in breast cancer metastasis, drug resistance and RAS pathways could potentially have applications in medical practice.
- Published
- 2011
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