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Start Over Author "N. I. Baram" Journal genetika
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1. [Cytogenetic study of the effect of gossypol on mouse germ cells]

Author

S T, Zakhidov, S P, Pozniakov, I V, Uryvaeva, A I, Ismailov, and N I, Baram

Subjects
Cell Nucleus, Male, Mice, Gossypol, Animals, Sperm Head, Spermatids, Spermatozoa, Mutagens
Abstract

The clastogenic and mutagenic activities of a new antifertility and antitumor agent gossypol were studied in the mouse male germ cells. Results of the present work indicate that at the doses 125 and 250 mg/kg the drug does not significantly increase frequencies of the micronuclei in the early spermatids and sperm head abnormalities. Hence, genotoxic influence can not be proposed as responsible for the antifertility effect of gossypol.

Published
1987

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