1. Neuropsychiatric disorders in the 22q11 deletion syndrome
- Author
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Christopher Gillberg, Lena Niklasson, Peder Rasmussen, and Sólveig Óskarsdóttir
- Subjects
Adult ,Male ,Pediatrics ,medicine.medical_specialty ,Adolescent ,Chromosomes, Human, Pair 22 ,Neuropsychological Tests ,Nonverbal learning disorder ,22q11 Deletion Syndrome ,Intellectual Disability ,Intervention (counseling) ,medicine ,Humans ,Autistic Disorder ,Young adult ,Child ,Genetics (clinical) ,business.industry ,Mental Disorders ,medicine.disease ,Neuropsychiatric disorder ,Attention Deficit Disorder with Hyperactivity ,Child, Preschool ,Autism ,Female ,Chromosome Deletion ,business ,22q11 deletion - Abstract
Purpose: This study was undertaken with a view to establishing the occurrence of neuropsychiatric disorders in the 22q11 deletion syndrome. Methods: Thirty-two children and young adults with genetically confirmed 22q11 deletion were given comprehensive neuropsychiatric assessments. Results: Altogether, 56% had a neuropsychiatric disorder. Only 6% were of normal IQ and free of physchiatric disorder. Attention-deficit/hyperactivity disorder was diagnosed in 44% and 31% had an autism spectrum problem. In 16% criteria for both these diagnoses were met. Fifty-three percent had mental retardation, often with a test-profile suggesting a nonverbal learning disorder. Conclusion: The findings imply that a majority of children and adolescents with 22q11 deletion syndrome are in need of neuropsychiatric assessment and intervention.
- Published
- 2001