1. MCP-1 and CCR2 gene variants and the risk for osteoporosis and osteopenia.
- Author
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Eraltan H, Cacina C, Kahraman OT, Kurt O, Aydogan HY, Uyar M, Can A, and Cakmakoğlu B
- Subjects
- Adult, Aged, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Haplotypes, Humans, Middle Aged, Polymerase Chain Reaction, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Postmenopause, Bone Diseases, Metabolic genetics, Chemokine CCL2 genetics, Genetic Variation, Osteoporosis genetics, Receptors, CCR2 genetics
- Abstract
Aim: In this study, we investigated whether monocyte chemotactic protein 1 (MCP-1) and CC chemokine receptor 2 (CCR2) gene polymorphisms account for an increased risk of osteoporosis or osteopenia., Methods: Three hundred three postmenopausal women, 80 osteoporotic, 123 osteopenic, and 100 unrelated age-matched healthy controls, were included in the study. Genotyping of MCP-1 A2518G and CCR2 V64I gene polymorphisms were detected by PCR-RFLP., Results: We, for the first time, demonstrated the positive association of MCP-1 GG, CCR2 Val/Ile, and CCR2 Val+ genotype with osteoporosis risk. However, CCR2 Ile/Ile genotype frequencies were high in the control group compared with those of the patients with osteoporosis and osteopenia. Haplotype analysis confirmed the association of MCP-1/CCR2 gene variants with osteopenia and revealed that the frequency of MCP-1 A:CCR2 Val haplotype was significantly higher in patients when compared with controls., Conclusions: In conclusion, our findings have suggested that MCP-1 and CCR2 gene variants were risk factors for osteoporosis and osteopenia.
- Published
- 2012
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