1. CYP tool for induction and inhibition studies
- Author
-
Cali, James J., Sobol, Mary, Ma, Dongping, Uyeda, H. Tetsuo, and Meisenheimer, Poncho
- Subjects
Promega Corp. -- Product development ,Biotechnology industry -- Product development ,Drug metabolism -- Methods ,Drug metabolism -- Technology application ,Cytochrome P-450 -- Usage ,Technology application ,Biotechnology industry ,Business - Abstract
The cythochromes P450 (CYP) are the primary enzyme family for metabolism of therapeutic drugs and CYP3A4 is the most active drug metabolizing CYP. Promega's P450-Glo bioluminescent CYP assays give highly predictive results and rank highest for sensitivity and ease of use. Insights on the use of selective luciferin-isopropyl acetal CYP34 assay are also given.
- Published
- 2010