Search

Your search keyword '"Gallagher, G."' showing total 17 results
Start Over Author "Gallagher, G." Journal genes & immunity
17 results on '"Gallagher, G."'

17. Interferon lambda-1 (IFN-λ1/IL-29) induces ELR− CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-γ-independent manner.

Author

Pekarek, V., Srinivas, S., Eskdale, J., and Gallagher, G.

Subjects
INTERFERONS, ANTIVIRAL agents, ANTINEOPLASTIC agents, INFLAMMATORY mediators, MESSENGER RNA, IMMUNITY
Abstract

Interferon lambda-1 (IFN-λ1), the prototype Type-III interferon, has antiviral functions similar to those of the Type-I interferons, IFN-α and IFN-β. However, IFN-λ1 is capable of signaling through almost all STAT molecules and so it is possible that it may have novel immunoregulatory functions in addition to antiviral ones. From a range of chemokines tested, IFN-λ1 elevated mRNA levels of only ‘Monokine induced by IFN-gamma’ (MIG/CXCL9), ‘IFN-gamma inducible protein-10’ (IP-10/CXCL10) and ‘IFN-gamma inducible T-cell α chemoattractant’ (I-TAC/CXCL11) from human peripheral blood mononuclear cells. As their names suggest, these chemokines are also induced by IFN-γ, the only member of the Type-II interferon family. This action of IFN-λ1 did not depend on intermediate induction of IFN-γ and is therefore, likely to be independent of IFN-γ. Further, our results suggest that donors responded to IFN-λ1 stimulation either ‘early’ or ‘late’. Overall the action of IFN-λ1 was similar to that previously reported for IFN-γ and may invite more detailed investigation of the role of IFN-λ1 at the innate/adaptive interface.Genes and Immunity (2007) 8, 177–180. doi:10.1038/sj.gene.6364372; published online 25 January 2007 [ABSTRACT FROM AUTHOR]

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results