1. Retroelements: molecular features and implications for disease
- Author
-
Heui-Soo Kim, Jin-Han Bae, Kung Ahn, Yi-Deun Jung, Yun-Ji Kim, and Ja-Rang Lee
- Subjects
Genome instability ,Genetics ,Genome ,Retroelements ,General Medicine ,Computational biology ,Disease ,Biology ,Genomic Instability ,Evolution, Molecular ,MicroRNAs ,microRNA ,Animals ,Humans ,Epigenetics ,Molecular Biology ,Gene ,Function (biology) - Abstract
Eukaryotic genomes comprise numerous retroelements that have a major impact on the structure and regulation of gene function. Retroelements are regulated by epigenetic controls, and they generate multiple miRNAs that are involved in the induction and progression of genomic instability. Elucidation of the biological roles of retroelements deserves continuous investigation to better understand their evolutionary features and implications for disease.
- Published
- 2013
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