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Your search keyword '"Norton, Christine R."' showing total 3 results
Start Over Author "Norton, Christine R." Journal genes & development
3 results on '"Norton, Christine R."'

1. Notch signaling is essential for vascular morphogenesis in mice

Author

Krebs, Luke T., Xue, Yingzi, Norton, Christine R., Shutter, John R., Maguire, Maureen, Sundberg, John P., Gallahan, Daniel, Closson, Violaine, Kitajewski, Jan, Callahan, Robert, Smith, Gilbert H., Stark, Kevin L., and Gridley, Thomas

Subjects
Heredity -- Research, Morphogenesis -- Analysis, Gene expression -- Research, Ligands -- Research, Biological sciences
Abstract

Research has been conducted on the role of the Notch4 gene in the intercellular signaling mechanism. The generation of the Notch4-deficient mice by gene targeting is described.

Published
2000

2. Roles for Nkx3.1 (ital) in prostate development and cancer

Author

Bhatia-Gaur, Rajula, Donjacour, Annemarie A., Sciavolino, Peter J., Kim, Minjung, Desai, Nishita, Young, Peter, Norton, Christine R., Gridley, Thomas, Cardiff, Robert D., Cunha, Gerland R., Abate-Shen, Cory, and Shen, Michael M.

Subjects
Developmental biology -- Research, Homeobox genes -- Observations, Mice, mutant strains -- Research, Prostate -- Genetic aspects, Cancer -- Genetic aspects, Biological models -- Usage, Bulbourethral glands -- Genetic aspects, Hyperplasia -- Genetic aspects, Dysplasia -- Genetic aspects, Tumor suppressor genes -- Research, Cell differentiation -- Research, Biological sciences
Abstract

The mouse Nkx3.1 (ital) homeobox gene has roles in prostate development and in cancer. This gene is the earliest known marker of prostate epithelium in embryogenesis and is expressed after that at all stages of prostate differentiation in vivo and in tissue recombinants. NKX3.1 (ital) may be a prostate-specific tumor suppressor gene. Loss a single allele may constitute a predisposition to carcinogenesis in the prostate.

Published
1999

3. Defects in limb, craniofacial, and thymic development in Jagged2 mutnt mice

Author

Rulang Jiang, Yu Lan, Chapman, Harry D., Shawber, Carrie, Norton, Christine R., Serreze, David V., Weinmaster, Gerry, and Gridley, Thomas

Subjects
Proteins -- Research, Cells -- Morphology, Extremities (Anatomy) -- Genetic aspects, Biological sciences
Abstract

Jagged2 gene and Notch signaling, which is a intercellular signaling mechanism, play an important part in the limb, thymic and craniofacial development of mice. Mutant mice without a domain of the Jagged2 protein had fatal defects in craniofacial morphogenesis. The mice also had fusion in the limbs and modified thymic morphology.

Published
1998

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