1. A plethora of lesion-replicating DNA polymerases
- Author
-
Woodgate, Roger
- Subjects
DNA polymerases -- Research ,DNA ,Homology (Biology) -- Physiological aspects ,Yeast -- Genetic aspects ,Bacteria -- Genetic aspects ,Human beings -- Genetic aspects ,DNA repair -- Research ,Biological sciences - Abstract
Recent findings relating to lesion-replicating DNA polymerases, of which there are many and which are key participants in translesion replication, are discussed. It appears that yeast, bacteria and humans accomplish tranlesion DNA synthesis by a common mechanism and in each case the main replicase for the organism, unable to bypass the lesion, dissociates from the template to leave a 3' primer terminus before the lesion. Then translesion replication is catalyzed by one of the DNA polymerases recently described.
- Published
- 1999