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2 results on '"Ubiali G."'

1. Immature Immunoglobulin Gene Rearrangements Are Recurrent in B Precursor Adult Acute Lymphoblastic Leukemia Carrying TP53 Molecular Alterations

Author

Tamara Intermesoli, Roberta Cavagna, Elena Oldani, Anna Salvi, Greta Ubiali, Barbara Peruta, Renato Bassan, Marie Lorena Guinea Montalvo, Alessandro Rambaldi, Orietta Spinelli, Ursula Giussani, Chiara Pavoni, Manuela Tosi, S Salmoiraghi, Salmoiraghi, S, Cavagna, R, Montalvo, M, Ubiali, G, Tosi, M, Peruta, B, Intermesoli, T, Oldani, E, Salvi, A, Pavoni, C, Giussani, U, Bassan, R, Rambaldi, A, and Spinelli, O

Subjects
immunoglobulin rearrangements, biology, Adult patients, lcsh:QH426-470, Immunoglobulin rearrangement, T-cell receptor, Clone (cell biology), acute lymphoblastic leukemia, Minimal residual disease, Molecular biology, 03 medical and health sciences, Transformation (genetics), lcsh:Genetics, 0302 clinical medicine, 030220 oncology & carcinogenesis, Genetics, biology.protein, Adult Acute Lymphoblastic Leukemia, TP53, Antibody, Immunoglobulin Gene Rearrangement, Genetics (clinical), 030215 immunology
Abstract

Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alterations, which represents a marker of poor prognosis, was strictly correlated with an immature DH/JH rearrangement of the immunoglobulin receptor (p < 0.0001). Furthermore, TP53-mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). Although the reasons for the co-presence of immature Ig rearrangements and TP53 mutation need to be clarified, this can suggest that the alteration in TP53 is acquired at an early stage of B-cell maturation or even at the level of pre-leukemic transformation.

Published
2020

2. Immature Immunoglobulin Gene Rearrangements Are Recurrent in B Precursor Adult Acute Lymphoblastic Leukemia Carrying TP53 Molecular Alterations.

Author

Salmoiraghi S, Cavagna R, Guinea Montalvo ML, Ubiali G, Tosi M, Peruta B, Intermesoli T, Oldani E, Salvi A, Pavoni C, Giussani U, Bassan R, Rambaldi A, and Spinelli O

Subjects
Adolescent, Adult, Aged, Clinical Trials as Topic, Female, Follow-Up Studies, Gene Expression Regulation, Neoplastic, Humans, Male, Middle Aged, Prognosis, Retrospective Studies, Young Adult, Biomarkers, Tumor genetics, Gene Rearrangement, Genes, Immunoglobulin genetics, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma genetics, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma pathology, Tumor Suppressor Protein p53 genetics
Abstract

Here, we describe the immunoglobulin and T cell receptor (Ig/TCR) molecular rearrangements identified as a leukemic clone hallmark for minimal residual disease assessment in relation to TP53 mutational status in 171 Ph-negative Acute Lymphoblastic Leukemia (ALL) adult patients at diagnosis. The presence of a TP53 alterations, which represents a marker of poor prognosis, was strictly correlated with an immature DH/JH rearrangement of the immunoglobulin receptor ( p < 0.0001). Furthermore, TP53 -mutated patients were classified as pro-B ALL more frequently than their wild-type counterpart (46% vs. 25%, p = 0.05). Although the reasons for the co-presence of immature Ig rearrangements and TP53 mutation need to be clarified, this can suggest that the alteration in TP53 is acquired at an early stage of B-cell maturation or even at the level of pre-leukemic transformation.

Published
2020
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