Search

Your search keyword '"Renieri, Alessandra"' showing total 6 results
Start Over Author "Renieri, Alessandra" Journal genes
6 results on '"Renieri, Alessandra"'

1. Genetic Modifiers of Mendelian Monogenic Collagen IV Nephropathies in Humans and Mice

Author

Deltas, Constantinos, primary, Papagregoriou, Gregory, additional, Louka, Stavroula F., additional, Malatras, Apostolos, additional, Flinter, Frances, additional, Gale, Daniel P., additional, Gear, Susie, additional, Gross, Oliver, additional, Hoefele, Julia, additional, Lennon, Rachel, additional, Miner, Jeffrey H., additional, Renieri, Alessandra, additional, Savige, Judy, additional, and Turner, A. Neil, additional

Published
2023
Full Text
View/download PDF

2. Liver Involvement in Patients with Rare MBOAT7 Variants and Intellectual Disability: A Case Report and Literature Review

Author

Ronzoni, Luisa, primary, Mureddu, Matteo, additional, Malvestiti, Francesco, additional, Moretti, Vittoria, additional, Bianco, Cristiana, additional, Periti, Giulia, additional, Baldassarri, Margherita, additional, Ariani, Francesca, additional, Carrer, Anna, additional, Pelusi, Serena, additional, Renieri, Alessandra, additional, Prati, Daniele, additional, and Valenti, Luca, additional

Published
2023
Full Text
View/download PDF

5. 13q Deletion Syndrome Involving RB1: Characterization of a New Minimal Critical Region for Psychomotor Delay

Author

Privitera, Flavia, primary, Calonaci, Arianna, additional, Doddato, Gabriella, additional, Papa, Filomena Tiziana, additional, Baldassarri, Margherita, additional, Pinto, Anna Maria, additional, Mari, Francesca, additional, Longo, Ilaria, additional, Caini, Mauro, additional, Galimberti, Daniela, additional, Hadjistilianou, Theodora, additional, De Francesco, Sonia, additional, Renieri, Alessandra, additional, and Ariani, Francesca, additional

Published
2021
Full Text
View/download PDF

6. Protective Role of a TMPRSS2 Variant on Severe COVID-19 Outcome in Young Males and Elderly Women.

Author

Monticelli, Maria, Hay Mele, Bruno, Benetti, Elisa, Fallerini, Chiara, Baldassarri, Margherita, Furini, Simone, Frullanti, Elisa, Mari, Francesca, Andreotti, Giuseppina, Cubellis, Maria Vittoria, and Renieri, Alessandra

Subjects
OLDER women, COVID-19, VIRUS diseases, OXYGEN therapy, SARS-CoV-2
Abstract

The protease encoded by the TMPRSS2 gene facilitates viral infections and has been implicated in the pathogenesis of SARS-CoV-2. We analyzed the TMPRSS2 sequence and correlated the protein variants with the clinical features of a cohort of 1177 patients affected by COVID-19 in Italy. Nine relatively common variants (allele frequency > 0.01) and six missense variants which may affect the protease activity according to PolyPhen-2 in HumVar-trained mode were identified. Among them, p.V197M (p.Val197Met) (rs12329760) emerges as a common variant that has a deleterious effect on the protease and a protective effect on the patients. Its role appears particularly relevant in two subgroups of patients—young males and elderly women—and among those affected by co-morbidities, where the variant frequency is higher among individuals who were mildly affected by the disease and did not need hospitalization or oxygen therapy than among those more severely affected, who required oxygen therapy, ventilation or intubation. This study provides useful information for the identification of patients at risk of developing a severe form of COVID-19, and encourages the usage of drugs affecting the expression of TMPRSS2 or inhibiting protein activity. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results