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1. Sensitivity of the brain synaptosomal membrane Mg(2+)-ATPase activity to arachidonic acid is under control of the Na+,K(+)-ATPase state.

Author

Okun IM, Lyskova TI, Aksentsev SL, and Konev SV

Subjects
Animals, Ca(2+) Mg(2+)-ATPase antagonists & inhibitors, In Vitro Techniques, Indomethacin pharmacology, Ouabain pharmacology, Prostaglandin D2 pharmacology, Rats, Sodium-Potassium-Exchanging ATPase antagonists & inhibitors, Sodium-Potassium-Exchanging ATPase metabolism, Substrate Specificity, Synaptosomes enzymology, Arachidonic Acid pharmacology, Brain enzymology, Ca(2+) Mg(2+)-ATPase metabolism
Abstract

Evidence is presented for the sensitivity of the synaptosomal plasma membrane Mg(2+)-ATPase activity to arachidonic acid being dependent on the functional state of Na+,K(+)-ATPase. An "Inversion effect" was observed at arachidonic acid concentrations exceeding 80 mumol/l when the Mg(2+)-ATPase activity (after ouabain addition) is higher than the total ATPase activity (without ouabain). The "Inversion effect" is reduced by cyclooxygenase inhibitor indomethacin or acetylsalicylic acid and restored by prostaglandin PGA2 or PGD2.

Published
1992

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