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1. Comparison of the antiplatelet agent potential of the whole molecule, F(ab)2 and Fab fragments of humanized anti-GPIIb/IIIa monoclonal antibody in monkeys.

Author

Kaku S, Yano S, Kawasaki T, Sakai Y, Suzuki K, Kawamura K, Masuho Y, Satoh N, Takenaka T, Landolfi NF, and Co MS

Subjects
Animals, Bleeding Time, Humans, In Vitro Techniques, Macaca mulatta, Mice, Mice, Inbred BALB C, Platelet Aggregation drug effects, Platelet Count drug effects, Antibodies, Monoclonal pharmacology, Immunoglobulin Fab Fragments immunology, Platelet Aggregation Inhibitors pharmacology, Platelet Glycoprotein GPIIb-IIIa Complex immunology
Abstract

1. The potential antiplatelet agent use of the whole molecule, F(ab)2 and Fab fragments of humanized antiglycoprotein (GP) IIb/IIIa monoclonal antibody, hC4G1, were investigated in rhesus monkeys. 2. Fab completely inhibited platelet aggregation 1 hr after an i.v. bolus administration of 1 mg/kg without a decrease in platelet count or prolongation of bleeding time, and the duration of inhibition was much shorter than that of F(ab)2. 3. These results suggest that the Fab fragment of hC4G1 may be a more useful antiplatelet agent in patients with acute thromboembolic diseases than the whole molecule or F(ab)2 fragments.

Published
1996
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