1. Reversible posterior leukoencephalopathy syndrome after withdrawal of antipsychotic medication in the context of lithium intoxication
- Author
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Sebastian Loens, Josef Conzen, Karin Weissenborn, Gabriel Simon Welte, Christoph Schrader, and Nicole Scharn
- Subjects
business.industry ,medicine.medical_treatment ,Lithium intoxication ,Context (language use) ,Schizoaffective disorder ,Middle Aged ,medicine.disease ,Psychotropic medication ,Reversible posterior leukoencephalopathy syndrome ,Psychiatry and Mental health ,Blood pressure ,Psychotic Disorders ,Antimanic Agents ,Anesthesia ,Lithium Compounds ,Humans ,Medicine ,Female ,Posterior Leukoencephalopathy Syndrome ,business ,Antipsychotic ,Rhabdomyolysis ,Antipsychotic Agents - Abstract
Objective To report a case of reversible posterior leukoencephalopathy syndrome (RPLS) after withdrawal of antipsychotic medication in a patient with acute lithium intoxication. Methods Case report. Results A patient with schizoaffective disorder was admitted with lithium intoxication, rhabdomyolysis and acute renal failure. After withdrawal of psychotropic medication, she developed a significant increase in blood pressure — though to moderately hypertensive levels — and prolonged disturbance of consciousness with profound agitation. MRI revealed RPLS. Resumption of antipsychotic treatment resulted in significant drop of blood pressure and improvement. Conclusion Acute withdrawal of antipsychotic medication may lead to rebound hypertension and development of RPLS, especially in the presence of lithium intoxication and renal dysfunction.
- Published
- 2015
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