1. Insight into stem cell regulation from sub-lethally irradiated worms
- Author
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Luigi Tana, Claudio Ghezzani, Paola Iacopetti, Gregory Gimenez, Eric Ghigo, Alessandra Salvetti, Lucia Cassella, and Leonardo Rossi
- Subjects
0301 basic medicine ,Cellular differentiation ,Messenger ,Models, Biological ,03 medical and health sciences ,0302 clinical medicine ,Models ,RNA interference ,Niche ,Genetics ,Control network ,Gene silencing ,Animals ,Regeneration ,Developmental ,RNA, Messenger ,Gene ,Planarian ,biology ,Gene Expression Profiling ,Stem Cells ,X-Rays ,Gene Expression Regulation, Developmental ,Neoblast ,RNAi ,Cell Differentiation ,Planarians ,General Medicine ,Biological ,biology.organism_classification ,Cell biology ,030104 developmental biology ,Gene Expression Regulation ,RNA ,Repopulation ,Stem cell ,030217 neurology & neurosurgery - Abstract
Despite the significant advances in the comprehension of stem cell control network, the nature of extrinsic signals regulating their dynamic remains to be understood. In this paper, we take advantage of the stem cell repopulation process that follows low-dose X-ray treatment in planarians to identify genes, preferentially enriched in differentiated cells, whose expression is activated during the process. Genetic silencing of some of them impaired the stem cell repopulation, suggesting a tight extrinsic control of stem cell activity.
- Published
- 2018