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Lidocaine belongs to class 1-B antiarrhythmic agents and is primarily used in the treatment of ventricular arrhythmias. This agent is also used in pharmaceutical cocktails as a pain reliever for conditions such as aphthous stomatitis and dyspepsia. Regardless of its efficacy, it is necessary to consider the safety of lidocaine in pharmaceutical cocktails. Some conditions can alter its pharmacokinetics, and the absorption of lidocaine can increase significantly. Toxic levels of lidocaine in the blood can cause severe toxic symptoms, especially in the central nervous system and the cardiac system. Neurotoxic symptoms such as respiratory depression, convulsion, and coma appear at mild toxicity but cardiotoxic symptoms appear in severe toxicity. These devastating effects of lidocaine toxicity are a warning for the health care providers regarding the irrational usage of this agent in oral pharmaceutical cocktails, especially community pharmacists who are not aware of the toxic effects of lidocaine ingestion, and hence, they should be advised to avoid preparing oral pharmaceutical cocktails using lidocaine. [ABSTRACT FROM AUTHOR]