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Objective: Estrogen is thought to play a protective role in a predisposition to the Parkinson's disease (PD). It was aimed to investigate the frequency of total abdominal hysterectomy-bilateral salpingo-oophorectomy (TAH-BSO) history causing withdrawal estrogen in women with PD in this study. Methods: The electronic records of the Movement Disorders Unit of the Neurology Department were reviewed. Female with PD were selected and compared with agematched controls without movement disorders. The patients were divided into two groups (<45 years and ≥45 years) according to their age at TAH-BSO to investigate the effect of premature estrogen withdrawal. Characteristics of PD were evaluated in these groups. Results: Total 675 patients and 125 controls were included. The frequency of TAHBSO was found higher in patients (15.3%) than controls (12%) but it was not significantly (p=0.34). Age of symptom onset, disease severity and daily levodopa dose were not different in patients (n=30) with age at TAH-BSO <45 years compared with the patients (n=73) with those ≥45 years at TAH-BSO. Risk of PD was found to be slightly increased in patients aged <40 years at the time of surgery (OR=1.94, 95% CI: 0.19-19.59, p=0.57) compared with those aged 40-44 years (OR=0.39, 95% CI: 0.10-1.49, p=0.17) and >45 years (OR=1.58, 95% CI: 0.32-7.80, p=0.57). Conclusion: The frequency of TAH-BSO history in women with PD is not different compared to the control group. Risk of PD may slightly increased in patients aged <40 years of TAH-BSO. Age of TAH-BSO did not affect the analyzed clinical parameters of PD. [ABSTRACT FROM AUTHOR]