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3. Unroofing for lymphangioma of the large intestine: a new approach to endoscopic treatment

Author

Masanori Hashimoto, Takeshi Oohara, Masanori Kobayashi, Kaoru Kobayashi, Shu Kuramoto, Kazuki Yamasaki, and Toshiki Mimura

Subjects
Adult, Male, medicine.medical_specialty, Colonoscopy, Lymphangioma, medicine, Humans, Radiology, Nuclear Medicine and imaging, Large intestine, Intestine, Large, Aged, medicine.diagnostic_test, business.industry, General surgery, Submucosal tumor, Gastroenterology, Endoscopy, Middle Aged, Lipoma, medicine.disease, Surgery, body regions, medicine.anatomical_structure, Female, Colorectal Neoplasms, business, Endoscopic treatment, Rare disease
Abstract

Colorectal lymphangioma was long considered a rare disease, as we ourselves noted in a report in 1988 of a lymphangioma of the large intestine. At that time we found only 82 cases in the English and Japanese language literature. 1 However, it is now known to be not so rare, as more than 100 cases have been reported in Japan alone. 2-5 This change has been brought about by the technologic developments and subsequent widespread use of colonoscopy as well as improvements in colonic preparation. In addition, the trend in treatment for colorectal lymphangiomas seems to have changed from surgery to endoscopic procedures, 1'3 although most lymphangiomas are asymptomatic and do not require any- treatment. The endoscopic method for their removal has also undergone revision. Over the last decade, we have encountered eight patients with a colorectal lymphangioma. This tumor now seems to be the most common submucosal tumor of the large intestine except for lipoma. In order to detect colorectal lymphangioma, which is not rare but can easily be missed, it was necessary for us to anticipate its existence and to become thoroughly familiar with its endoscopic characteristics. We here summarize eight cases of colorectal lymphangioma, focusing on its endoscopic features and a new endoscopic treatment that we call unroofing.

Published
1997
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4. 743 Evaluation of the Clinical Efficacy of Colon Capsule Endoscopy in the Detection of Lesion of the Colon - Prospective Multicenter Study in Japan

Author

Hisao Tajiri, Sadaharu Nouda, Kenji Watanabe, Kazuhide Higuchi, Taiki Aoyama, Ikue Watari, Tetsuo Arakawa, Minori Matsumoto, Shiro Oka, Hiroyuki Aihara, Hidemi Goto, Takanori Kuramoto, Shoichi Saito, Shinji Tanaka, Yutaka Saito, Naoki Ohmiya, and Yasuo Kakugawa

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, law.invention, Lesion, Multicenter study, Capsule endoscopy, law, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, Clinical efficacy, medicine.symptom, business
Published
2014
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5. In vivo trial of a driving system for a self-propelling capsule endoscope using a magnetic field (with video)

Author

Naotake Ohtsuka, Mitsuyuki Murano, Eiji Umegaki, Kazuhide Higuchi, Takanori Kuramoto, Takuya Inoue, Yasunori Shindo, Sadaharu Nouda, and Eijiro Morita

Subjects
medicine.medical_specialty, Endoscope, Outcome measurements, Video-Audio Media, Capsule Endoscopy, law.invention, Microactuator, Animal model, Dogs, Electromagnetic Fields, Capsule endoscopy, law, Medicine, Animals, Radiology, Nuclear Medicine and imaging, CLIPS, computer.programming_language, business.industry, Gastroenterology, Capsule, Equipment Design, Surgery, Models, Animal, Female, business, computer, Biomedical engineering
Abstract

Background A capsule endoscope does not allow the examiner to observe a lesion from the desired direction in real time. Objective To develop a driving system for a self-propelling capsule endoscope (SPCE) by using a magnetic field. Setting Experimental endoscopic study in a live dog model. Design and Interventions A microactuator was developed with the aim of remote-control operation. We developed a driving system for SPCE by attaching a capsule endoscope to this medical microactuator and performed the following experiments. (1) We operated this SPCE by remote control in the stomach of a dog under sedation and obtained endoscopic images using a real-time monitoring system only. (2) We placed a hemostatic clip on the gastric mucosa and recorded images of this clip with the SPCE. (3) We also placed clips at 2 other sites in the stomach and asked the SPCE operator, who was unaware of the location of the clips, to identify the site, number, and color of the clips. Main Outcome Measurements Evaluation of performance of a driving system for SPCE. Results The operator was able to obtain endoscopic images with the SPCE in the stomach of a dog in vivo, in any desired direction, by remote control. SPCE produced clear images of the clips placed in the stomach. The operator was able to easily identify the site, number, and color of the clips. Limitations Animal model. Conclusions Our trial suggests the possibility of clinical application of the driving system for an SPCE using a magnetic field.

Published
2010

6. Sa1627 Prophylactic Effect of Egualen Sodium Hydrate on Small-Intestinal Mucosal Damage Induced by Low-Dose Aspirin in Healthy Subjects. : a Prospective Randomized Clinical Trial

Author

Kaori Fujiwara, Sadaharu Nouda, Daisuke Masuda, Kumi Ishida, Kazuhide Higuchi, Akira Imoto, Taisuke Sakanaka, Kazuki Kakimoto, Ken Narabayashi, Satoshi Harada, Shoko Edogawa, Yosuke Abe, Kazuhiro Ota, Toshihisa Takeuchi, Satoshi Tokioka, Ken Kawakami, Takuya Inoue, Yuichi Kojima, Takanori Kuramoto, Eiji Umegaki, and Takeshi Ogura

Subjects
Randomized controlled trial, law, business.industry, Anesthesia, Gastroenterology, Healthy subjects, Medicine, Radiology, Nuclear Medicine and imaging, Egualen sodium, business, Low dose aspirin, law.invention
Published
2013
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7. Mo1685 Comparison of the Performances of Two Kinds of Self-Propelling Capsule Endoscopes, Using PillCam®SB2 and PillCam®Eso2

Author

Kazuhiro Ota, Yoshiaki Fujito, Eiji Umegaki, Takuya Inoue, Yasunori Shindo, Sadaharu Nouda, Kenshiro Uesugi, Kazuhide Higuchi, Takanori Kuramoto, Toshihisa Takeuchi, Naotake Ohtsuka, Hironori Nishihara, and Satoshi Tokioka

Subjects
Capsule Endoscopes, business.industry, Gastroenterology, Medicine, Radiology, Nuclear Medicine and imaging, business, Biomedical engineering
Published
2013
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8. Sa1624 Effect of Long-Term PPI Administration on NSAID-Induced Small Intestinal Lesions and Therapeutic Effect of Irsogladine, a Gastroprotective Drug, for Such Lesions in Healthy Volunteers

Author

Takanori Kuramoto, Ken Narabayashi, Yuichi Kojima, Kumi Ishida, Satoshi Tokioka, Takuya Inoue, Yosuke Abe, Sadaharu Nouda, Ken Kawakami, Toshihisa Takeuchi, Eiji Umegaki, and Kazuhide Higuchi

Subjects
Drug, business.industry, media_common.quotation_subject, Therapeutic effect, Gastroenterology, Pharmacology, chemistry.chemical_compound, chemistry, Healthy volunteers, Medicine, Radiology, Nuclear Medicine and imaging, business, Irsogladine, media_common
Published
2013
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9. 743 Evaluation of the Clinical Efficacy of Colon Capsule Endoscopy in the Detection of Lesion of the Colon - Prospective Multicenter Study in Japan

Author

Oka, Shiro, primary, Tanaka, Shinji, additional, Saito, Yutaka, additional, Saito, Shoichi, additional, Kakugawa, Yasuo, additional, Matsumoto, Minori, additional, Aihara, Hiroyuki, additional, Watari, Ikue, additional, Aoyama, Taiki, additional, Nouda, Sadaharu, additional, Kuramoto, Takanori, additional, Watanabe, Kenji, additional, Ohmiya, Naoki, additional, Higuchi, Kazuhide, additional, Goto, Hidemi, additional, Arakawa, Tetsuo, additional, and Tajiri, Hisao, additional

Published
2014
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10. Sa1731 Usefulness of Capsule Endoscopy and Lewis Score in Japanese Patients With Crohn's Disease

Author

Kumi Ishida, Satoshi Tokioka, Sadaharu Nouda, Ken Narabayashi, Takuya Inoue, Akira Imoto, Yukiko Yoda, Ken Kawakami, Mitsuyuki Murano, Yosuke Abe, Kazuhide Higuchi, Daisuke Masuda, Takanori Kuramoto, Yuichi Kojima, Toshihisa Takeuchi, Eijiro Morita, and Eiji Umegaki

Subjects
medicine.medical_specialty, Crohn's disease, Capsule endoscopy, law, business.industry, Internal medicine, Gastroenterology, Medicine, Radiology, Nuclear Medicine and imaging, business, medicine.disease, law.invention
Published
2012
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11. W1595: New Scoring System for Mucosal Lesions of Portal Hypertensive Enteropathy Detected by Capsule Endoscopy: Prospective Study

Author

Katsuhiko Miyaji, Usama M. Abdelaal, Sadaharu Nouda, Akira Fukuda, Takanori Kuramoto, Kazuhide Higuchi, Mitsuyuki Murano, Eiji Umegaki, Satoshi Tokioka, Eijiro Morita, Yasuhiro Tsuda, and Hideo Fukui

Subjects
medicine.medical_specialty, Scoring system, business.industry, Mucosal lesions, Gastroenterology, medicine.disease, law.invention, Capsule endoscopy, law, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, Enteropathy, Radiology, business, Prospective cohort study
Published
2010
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12. Comparative Study of Conventional Colonoscopy and Pan-Colonic Narrow-Band Imaging System in the Detection of Neoplastic Colonic Polyps: A Randomized, Controlled Trial

Author

Yutaro Egashira, Mitsuyuki Murano, Naoko Murano, Ken Kawakami, Takanori Kuramoto, Takuya Inoue, Eiji Umegaki, Kazuhide Higuchi, Ken Toshina, Eijiro Morita, and Yosuke Abe

Subjects
medicine.medical_specialty, Narrow-band imaging, Randomized controlled trial, business.industry, law, Gastroenterology, medicine, Radiology, Nuclear Medicine and imaging, Conventional colonoscopy, Radiology, business, Surgery, law.invention
Published
2008
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13. Mo1469 What Is the Appropriate Strategy of Diagnosis of IPMN?

Author

Masuda, Daisuke, primary, Imoto, Akira, additional, Ogura, Takeshi, additional, Narabayashi, Ken, additional, Nouda, Sadaharu, additional, Kuramoto, Takanori, additional, Ishida, Kumi, additional, Abe, Yosuke, additional, Takeuchi, Toshihisa, additional, Inoue, Takuya, additional, Tokioka, Satoshi, additional, Takii, Michiaki, additional, Umegaki, Eiji, additional, and Higuchi, Kazuhide, additional

Published
2013
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14. Sa1627 Prophylactic Effect of Egualen Sodium Hydrate on Small-Intestinal Mucosal Damage Induced by Low-Dose Aspirin in Healthy Subjects. : a Prospective Randomized Clinical Trial

Author

Kuramoto, Takanori, primary, Umegaki, Eiji, additional, Fujiwara, Kaori, additional, Harada, Satoshi, additional, Sakanaka, Taisuke, additional, Ota, Kazuhiro, additional, Edogawa, Shoko, additional, Kojima, Yuichi, additional, Narabayashi, Ken, additional, Ogura, Takeshi, additional, Imoto, Akira, additional, Kakimoto, Kazuki, additional, Nouda, Sadaharu, additional, Ishida, Kumi, additional, Kawakami, Ken, additional, Abe, Yosuke, additional, Masuda, Daisuke, additional, Takeuchi, Toshihisa, additional, Inoue, Takuya, additional, Tokioka, Satoshi, additional, and Higuchi, Kazuhide, additional

Published
2013
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15. Tu1350 Usefulness of Lewis Score of Capsule Endoscopy in Japanese Patients With Crohn's Disease

Author

Nouda, Sadaharu, primary, Inoue, Takuya, additional, Umegaki, Eiji, additional, Ota, Kazuhiro, additional, Sakanaka, Taisuke, additional, Harada, Satoshi, additional, Fujiwara, Kaori, additional, Edogawa, Shoko, additional, Ogura, Takeshi, additional, Narabayashi, Ken, additional, Imoto, Akira, additional, Kakimoto, Kazuki, additional, Ishida, Kumi, additional, Kuramoto, Takanori, additional, Abe, Yosuke, additional, Takeuchi, Toshihisa, additional, Masuda, Daisuke, additional, Tokioka, Satoshi, additional, and Higuchi, Kazuhide, additional

Published
2013
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16. Sa1624 Effect of Long-Term PPI Administration on NSAID-Induced Small Intestinal Lesions and Therapeutic Effect of Irsogladine, a Gastroprotective Drug, for Such Lesions in Healthy Volunteers

Author

Kojima, Yuichi, primary, Kuramoto, Takanori, additional, Nouda, Sadaharu, additional, Narabayashi, Ken, additional, Ishida, Kumi, additional, Kawakami, Ken, additional, Abe, Yosuke, additional, Takeuchi, Toshihisa, additional, Inoue, Takuya, additional, Tokioka, Satoshi, additional, Umegaki, Eiji, additional, and Higuchi, Kazuhide, additional

Published
2013
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17. Sa1621 The Performances of Observe and Drive About Self-Propelling Capsule Endoscopes

Author

Kuramoto, Takanori, primary, Nouda, Sadaharu, additional, Ota, Kazuhiro, additional, Kojima, Yuichi, additional, Inoue, Takuya, additional, Takeuchi, Toshihisa, additional, Tokioka, Satoshi, additional, Umegaki, Eiji, additional, Uesugi, Kenshiro, additional, Shindo, Yasunori, additional, Nishihara, Hironori, additional, Ohtsuka, Naotake, additional, and Higuchi, Kazuhide, additional

Published
2013
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18. Mo1685 Comparison of the Performances of Two Kinds of Self-Propelling Capsule Endoscopes, Using PillCam®SB2 and PillCam®Eso2

Author

Ota, Kazuhiro, primary, Nouda, Sadaharu, additional, Kuramoto, Takanori, additional, Inoue, Takuya, additional, Takeuchi, Toshihisa, additional, Tokioka, Satoshi, additional, Umegaki, Eiji, additional, Uesugi, Kenshiro, additional, Fujito, Yoshiaki, additional, Shindo, Yasunori, additional, Nishihara, Hironori, additional, Ohtsuka, Naotake, additional, and Higuchi, Kazuhide, additional

Published
2013
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19. Tu1350 Usefulness of Lewis Score of Capsule Endoscopy in Japanese Patients With Crohn's Disease

Author

Kaori Fujiwara, Sadaharu Nouda, Kumi Ishida, Kazuhide Higuchi, Akira Imoto, Yosuke Abe, Takeshi Ogura, Shoko Edogawa, Taisuke Sakanaka, Takuya Inoue, Ken Narabayashi, Kazuki Kakimoto, Toshihisa Takeuchi, Satoshi Tokioka, Daisuke Masuda, Takanori Kuramoto, Kazuhiro Ota, Satoshi Harada, and Eiji Umegaki

Subjects
medicine.medical_specialty, Crohn's disease, business.industry, Gastroenterology, Treatment Setting, Clinical settings, Readmission rate, medicine.disease, law.invention, Capsule endoscopy, law, Internal medicine, Mucosal healing, medicine, Radiology, Nuclear Medicine and imaging, business
Abstract

and then had received scheduled maintenance IFX. Similarly, in the Re-set IFX group, patients received scheduled maintenance IFX immediately following surgery to eliminate active CD lesions. Both groups were followed for 3 to 5 years during which patients’ disease profiles were monitored with a keen interest in mucosal healing. Results: During 1, 2 and 5 years of follow up, remission maintenance rates were 58.3%, 37.5%, and 16.2%, respectively in the RIFX group. The corresponding maintenance remission rates in the Re-set IFX group were 91.7%, 69.5% and 51.7%. Likewise, complete mucosal healing rate at 3 years was 29.6% in the RIFX group and 75.0% in the Re-set IFX group, reflecting vastly better maintenance efficacy rates in the Re-set IFX group vs RIFX group. Readmission rate was 50.0% in the RIFX group vs 21.2% in the Re-set IFX group, while re-operation rate was 23.3% in the RIFX group and 12.1% in the Re-set IFX group. Conclusions: In the clinical settings described above, scheduled maintenance IFX therapy appeared to produce improved efficacy outcomes when initiated immediately after resections of active CD lesions. More notably, the efficacy of IFX to induce mucosal healing was better in the Re-set treatment setting vs routine setting.

Published
2013
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20. Sa1621 The Performances of Observe and Drive About Self-Propelling Capsule Endoscopes

Author

Takanori Kuramoto, Kazuhide Higuchi, Sadaharu Nouda, Eiji Umegaki, Yasunori Shindo, Toshihisa Takeuchi, Yuichi Kojima, Kenshiro Uesugi, Kazuhiro Ota, Naotake Ohtsuka, Takuya Inoue, Hironori Nishihara, and Satoshi Tokioka

Subjects
Capsule Endoscopes, business.industry, Gastroenterology, Medicine, Radiology, Nuclear Medicine and imaging, business, Biomedical engineering
Published
2013
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21. Mo1469 What Is the Appropriate Strategy of Diagnosis of IPMN?

Author

Ken Narabayashi, Sadaharu Nouda, Takeshi Ogura, Akira Imoto, Kumi Ishida, Michiaki Takii, Daisuke Masuda, Takuya Inoue, Eiji Umegaki, Yosuke Abe, Takanori Kuramoto, Kazuhide Higuchi, Toshihisa Takeuchi, and Satoshi Tokioka

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Medicine, Radiology, Nuclear Medicine and imaging, Medical physics, business
Published
2013
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22. Sa1735 Prophylactic Effect of Gastromucoprotective Drugs on NSAIDs-Induced Esophageal, Gastric, Duodenal, and Small Intestinal Mucosal Injury in Healthy Subjects: A Prospective Randomized Study

Author

Umegaki, Eiji, primary, Kojima, Yuichi, additional, Yoda, Yukiko, additional, Kuramoto, Takanori, additional, Nouda, Sadaharu, additional, Takeuchi, Toshihisa, additional, Ishida, Kumi, additional, Inoue, Takuya, additional, Tokioka, Satoshi, additional, and Higuchi, Kazuhide, additional

Published
2012
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23. Sa1731 Usefulness of Capsule Endoscopy and Lewis Score in Japanese Patients With Crohn's Disease

Author

Nouda, Sadaharu, primary, Inoue, Takuya, additional, Kojima, Yuichi, additional, Narabayashi, Ken, additional, Imoto, Akira, additional, Yoda, Yukiko, additional, Ishida, Kumi, additional, Kawakami, Ken, additional, Kuramoto, Takanori, additional, Abe, Yosuke, additional, Takeuchi, Toshihisa, additional, Masuda, Daisuke, additional, Morita, Eijiro, additional, Murano, Mitsuyuki, additional, Tokioka, Satoshi, additional, Umegaki, Eiji, additional, and Higuchi, Kazuhide, additional

Published
2012
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25. Sa1729 Small Intestinal Mucosal Adaptation in the Long-Term Administration of a NSAID and the Efficacy of Irsogladine Maleate, a Gastroprptective Drug, and Omeprazole in Healthy Volunteers: A Prospective Randomized Trial

Author

Kuramoto, Takanori, primary, Umegaki, Eiji, additional, Nouda, Sadaharu, additional, Narabayashi, Ken, additional, Inoue, Takuya, additional, Takii, Michiaki, additional, Yoda, Yukiko, additional, Ishida, Kumi, additional, Kawakami, Ken, additional, Takeuchi, Toshihisa, additional, Murano, Mitsuyuki, additional, Tokioka, Satoshi, additional, and Higuchi, Kazuhide, additional

Published
2012
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26. Mo1428 Endoscopic and Histopathological Evaluation of Collagenous Colitis

Author

Narabayashi, Ken, primary, Murano, Mitsuyuki, additional, Kojima, Yuichi, additional, Okada, Toshihiko, additional, Nouda, Sadaharu, additional, Yoda, Yukiko, additional, Imoto, Akira, additional, Ishida, Kumi, additional, Kawakami, Ken, additional, Kuramoto, Takanori, additional, Abe, Yosuke, additional, Masuda, Daisuke, additional, Takeuchi, Toshihisa, additional, Inoue, Takuya, additional, Tokioka, Satoshi, additional, Egashira, Yutaro, additional, Umegaki, Eiji, additional, and Higuchi, Kazuhide, additional

Published
2012
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28. Tu1553 Irsogladine, a Gastroprotective Drug, Protects Against NSAID-Induced Esophagitis, Peptic Ulcers, and Small Intestinal Mucosal Damages in Healthy Subjects: A Prospective Randomised Study of Comparison With Omeprazole

Author

Kuramoto, Takanori, primary, Umegaki, Eiji, additional, Kojima, Yuichi, additional, Narabayashi, Ken, additional, Nouda, Sadaharu, additional, Yoda, Yukiko, additional, Ishida, Kumi, additional, Kawakami, Ken, additional, Takeuchi, Toshihisa, additional, Inoue, Takuya, additional, Murano, Mitsuyuki, additional, Tokioka, Satoshi, additional, and Higuchi, Kazuhide, additional

Published
2011
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29. Tu1544 The Safety and Efficacy of Rapid Induction Therapy of Tacrolimus With Severe Ulcerative Colitis Refractory to Steroid Therapy

Author

Murano, Mitsuyuki, primary, Narabayashi, Ken, additional, Nouda, Sadaharu, additional, Ishida, Kumi, additional, Kawakami, Ken, additional, Kuramoto, Takanori, additional, Abe, Yosuke, additional, Inoue, Takuya, additional, Murano, Naoko, additional, Morita, Eijiro, additional, Umegaki, Eiji, additional, and Higuchi, Kazuhide, additional

Published
2011
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31. Sa1729 Small Intestinal Mucosal Adaptation in the Long-Term Administration of a NSAID and the Efficacy of Irsogladine Maleate, a Gastroprptective Drug, and Omeprazole in Healthy Volunteers: A Prospective Randomized Trial

Author

Ken Narabayashi, Eiji Umegaki, Mitsuyuki Murano, Takanori Kuramoto, Yukiko Yoda, Sadaharu Nouda, Kazuhide Higuchi, Satoshi Tokioka, Ken Kawakami, Toshihisa Takeuchi, Kumi Ishida, Michiaki Takii, and Takuya Inoue

Subjects
Drug, medicine.medical_specialty, business.industry, media_common.quotation_subject, Gastroenterology, law.invention, Randomized controlled trial, law, Internal medicine, Healthy volunteers, medicine, Radiology, Nuclear Medicine and imaging, Irsogladine maleate, business, Omeprazole, media_common, medicine.drug
Published
2012
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32. Sa1735 Prophylactic Effect of Gastromucoprotective Drugs on NSAIDs-Induced Esophageal, Gastric, Duodenal, and Small Intestinal Mucosal Injury in Healthy Subjects: A Prospective Randomized Study

Author

Eiji Umegaki, Takuya Inoue, Yukiko Yoda, Kazuhide Higuchi, Yuichi Kojima, Toshihisa Takeuchi, Takanori Kuramoto, Kumi Ishida, Sadaharu Nouda, and Satoshi Tokioka

Subjects
Aspirin, medicine.medical_specialty, business.industry, Stomach, Gastroenterology, Small intestine, medicine.anatomical_structure, Internal medicine, medicine, Duodenum, Rebamipide, Radiology, Nuclear Medicine and imaging, Gastritis, medicine.symptom, Esophagus, business, Omeprazole, medicine.drug
Abstract

Sa1735 Prophylactic Effect of Gastromucoprotective Drugs on NSAIDsInduced Esophageal, Gastric, Duodenal, and Small Intestinal Mucosal Injury in Healthy Subjects: A Prospective Randomized Study Eiji Umegaki*, Yuichi Kojima, Yukiko Yoda, Takanori Kuramoto, Sadaharu Nouda, Toshihisa Takeuchi, Kumi Ishida, Takuya Inoue, Satoshi Tokioka, Kazuhide Higuchi 2nd Department of Internal Medicine, Osaka Medical College, Takatsuki, Japan Introduction: A variety of factors are involved in the formation of lesions induced by non-steroidal anti-inflammatory drugs (NSAIDs) in the small intestine, considered unaffected by acid, including intestinal flora, bile, and mucus, and as yet there are no established preventive or therapeutic measures. Gastromucoprotective agent such as geranylgeranylacetone (GGA), irsogladine (IG), and rebamipide (REB), is used in the treatment of gastritis and gastric ulcers, and prevented NSAID-induced small intestinal lesions in rats (Gastroenterology 2010;138:A-528). Recently there was the report that proton pump inhibitors exacerbate NSAID-induced small intestinal injury by iducing dysbiosis (Gastroenterology 2011;141:1314). In this study, we investigated whether gastromucoprotective agent monotherapy can protect against NSAIDinduced esophageal, gastric, duodenal, and small intestinal mucosal injury. Subjects and Methods: We randomly allocated healthy volunteers(each group: n 15), aged 20 years, to take (1) diclofenac 75mg plus famotidine 20mg daily or diclofenac 75mg plus GGA 150mg daily, (2) diclofenac 75mg plus omeprazole 10mg or diclofenac 75mg plus IG 4mg, (3) aspirin 100mg plus omeprazole 10mg, aspirin 100mg plus REB 300mg or aspirin 100mg plus REB 900mg. All subjects underwent upper gastrointestinal endoscopy and video capsule endoscopy(VCE) before and 2 weeks after the treatment period, and were evaluated for gastric and small intestinal lesions. Upper gastrointestinal mucosal injury was evaluated using the Modified Lanza Score(MLS), and small intestinal changes were scored for the number of 6 lesion types of: erythema, haemorrhage, erosions, ulcers, edema, and strictures. In addition, we measured fecal calprotectin levels, as a marker of digestive tract mucosal permeability. Results: 1)No significant differences were seen between gastromucoprotective agent groups and acid suppressive agent groups in the background of volunteers, and in the mean increase in esophageal, gastric and duodenal mucosal lesions. 2)When examining the total number of small intestinal mucosal injury, lesion development was suggested after administration in acid suppressive agent groups. However, there was no development in gastromucoprotective agent groups. 3)GGA/IG/REB significantly inhibited an increase in the fecal calprotectin level in comparison with acid suppressive agent in patients with NSAIDs-related digestive tract mucosal injury. Conclusions: A similar protective effect against NSAID-induced acute esophageal, gastric and duodenal mucosal injury was seen for gastromucoprotective agent and acid suppressive agent. The protective effect in the small intestine was clearly superior for gastromucoprotective agent, however, indicating that GGA/IG/REB monotherapy can protect against NSAID-induced acute mucosal injury to the esophagus, stomach, duodenum and small intestine.

Published
2012
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33. Mo1428 Endoscopic and Histopathological Evaluation of Collagenous Colitis

Author

Yukiko Yoda, Yutaro Egashira, Yuichi Kojima, Kazuhide Higuchi, Takanori Kuramoto, Toshihiko Okada, Takuya Inoue, Satoshi Tokioka, Akira Imoto, Mitsuyuki Murano, Eiji Umegaki, Daisuke Masuda, Toshihisa Takeuchi, Ken Kawakami, Sadaharu Nouda, Ken Narabayashi, Kumi Ishida, and Yosuke Abe

Subjects
Pathology, medicine.medical_specialty, Collagenous colitis, business.industry, Gastroenterology, medicine, Radiology, Nuclear Medicine and imaging, medicine.disease, business
Published
2012
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34. Sa1736 Prophylactic Effect of Rebamipide on Gastric/Small-Intestinal Mucosal Damage Induced by Low-Dose Aspirin: A Prospective Randomized Clinical Trial

Author

Toshihisa Takeuchi, Eiji Umegaki, Sadaharu Nouda, Yukiko Yoda, Yuichi Kojima, Takanori Kuramoto, Kazuhide Higuchi, Takuya Inoue, and Satoshi Tokioka

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, law.invention, Randomized controlled trial, law, Internal medicine, medicine, Rebamipide, Radiology, Nuclear Medicine and imaging, business, medicine.drug, Low dose aspirin
Published
2012
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35. W1594: New Method for Better Detection and Visualization of Vascular and Non-Vascular Lesions of Small Bowel by Using Blue Mode Viewing: Capsule Endoscopy Study

Author

Abdelaal, Usama M., primary, Morita, Eijiro, additional, Nouda, Sadaharu, additional, Kuramoto, Takanori, additional, Miyaji, Katsuhiko, additional, Fukui, Hideo, additional, Tsuda, Yasuhiro, additional, Fukuda, Akira, additional, Murano, Mitsuyuki, additional, Tokioka, Satoshi, additional, Umegaki, Eiji, additional, and Higuchi, Kazuhide, additional

Published
2010
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36. W1595: New Scoring System for Mucosal Lesions of Portal Hypertensive Enteropathy Detected by Capsule Endoscopy: Prospective Study

Author

Abdelaal, Usama M., primary, Morita, Eijiro, additional, Nouda, Sadaharu, additional, Kuramoto, Takanori, additional, Miyaji, Katsuhiko, additional, Fukui, Hideo, additional, Tsuda, Yasuhiro, additional, Fukuda, Akira, additional, Murano, Mitsuyuki, additional, Tokioka, Satoshi, additional, Umegaki, Eiji, additional, and Higuchi, Kazuhide, additional

Published
2010
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37. W1580: Geranylgeranylacetone Protects Against NSAIDs-Induced Gastric and Small Intestinal Mucosal Injuries in Healthy Subjects: A Prospective Randomised Study Compared With Famotidine

Author

Umegaki, Eiji, primary, Morita, Eijiro, additional, Nouda, Sadaharu, additional, Takeuchi, Toshihisa, additional, Yoda, Yukiko, additional, Ishida, Kumi, additional, Kuramoto, Takanori, additional, Tokioka, Satoshi, additional, Murano, Mitsuyuki, additional, and Higuchi, Kazuhide, additional

Published
2010
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39. 1080g: A New Slenderized Self-Propelling Capsule Endoscope Enabled Observation of Porcine'S Intestine

Author

Morita, Eijiro, primary, Ohtsuka, Naotake, additional, Murano, Mitsuyuki, additional, Nouda, Sadaharu, additional, Kuramoto, Takanori, additional, Kakimoto, Kazuki, additional, Ishida, Kumi, additional, Kawakami, Ken, additional, Abe, Yosuke, additional, Inoue, Takuya, additional, Shindo, Yasunori, additional, Umegaki, Eiji, additional, Nishihara, Hironori, additional, and Higuchi, Kazuhide, additional

Published
2010
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40. W1593: Usefulness of Polyethylene Glycol Solution for Bowel Preparation Before Capsule Endoscopy in Patients With Obscure Gastrointestinal Bleeding

Author

Nouda, Sadaharu, primary, Morita, Eijiro, additional, Kuramoto, Takanori, additional, Yoda, Yukiko, additional, Ishida, Kumi, additional, Kawakami, Ken, additional, Takeuchi, Toshihisa, additional, Murano, Mitsuyuki, additional, Tokioka, Satoshi, additional, Umegaki, Eiji, additional, and Higuchi, Kazuhide, additional

Published
2010
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42. Tu1544 The Safety and Efficacy of Rapid Induction Therapy of Tacrolimus With Severe Ulcerative Colitis Refractory to Steroid Therapy

Author

Sadaharu Nouda, Naoko Murano, Mitsuyuki Murano, Eijiro Morita, Ken Narabayashi, Eiji Umegaki, Takuya Inoue, Kazuhide Higuchi, Takanori Kuramoto, Yosuke Abe, Kumi Ishida, and Ken Kawakami

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, medicine.disease, Ulcerative colitis, Tacrolimus, Steroid therapy, Refractory, Internal medicine, Induction therapy, medicine, Radiology, Nuclear Medicine and imaging, business
Published
2011
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43. Tu1553 Irsogladine, a Gastroprotective Drug, Protects Against NSAID-Induced Esophagitis, Peptic Ulcers, and Small Intestinal Mucosal Damages in Healthy Subjects: A Prospective Randomised Study of Comparison With Omeprazole

Author

Toshihisa Takeuchi, Ken Narabayashi, Satoshi Tokioka, Yukiko Yoda, Kazuhide Higuchi, Takanori Kuramoto, Takuya Inoue, Sadaharu Nouda, Yuichi Kojima, Mitsuyuki Murano, Eiji Umegaki, Ken Kawakami, and Kumi Ishida

Subjects
Drug, medicine.medical_specialty, business.industry, Peptic, media_common.quotation_subject, Gastroenterology, Healthy subjects, medicine.disease, chemistry.chemical_compound, chemistry, Internal medicine, Medicine, Radiology, Nuclear Medicine and imaging, business, Esophagitis, Omeprazole, Irsogladine, medicine.drug, media_common
Published
2011
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44. Su1552 Retrograde Colon Capsule Endoscopy From Anus Using a New Self-Propelling Capsule; The First Human Trial

Author

Yuichi Kojima, Yasunori Shindo, Eiji Umegaki, Shin-ya Kinoshita, Naotake Ohtsuka, Hironori Nishihara, Takanori Kuramoto, Mitsuyuki Murano, and Kazuhide Higuchi

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Human trial, Capsule, Anus, Surgery, law.invention, medicine.anatomical_structure, Capsule endoscopy, law, Internal medicine, medicine, Radiology, Nuclear Medicine and imaging, business
Published
2011
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45. Usefulness of Mosapride Citrate As Preparation for Capsule Endoscopy

Author

Kuramoto, Takanori, primary, Morita, Eijiro, additional, Murano, Mitsuyuki, additional, Kakimoto, Kazuki, additional, Nouda, Sadaharu, additional, Ishida, Kumi, additional, Kawakami, Ken, additional, Abe, Yosuke, additional, Inoue, Takuya, additional, Murano, Naoko, additional, Umegaki, Eiji, additional, and Higuchi, Kazuhide, additional

Published
2009
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47. In Vivo Trial of Driving System for Capsule Endoscopy Using a Magnetic Field

Author

Morita, Eijiro, primary, Ohtsuka, Naotake, additional, Murano, Mitsuyuki, additional, Nouda, Sadaharu, additional, Kuramoto, Takanori, additional, Kakimoto, Kazuki, additional, Kawakami, Ken, additional, Ishida, Kumi, additional, Abe, Yosuke, additional, Inoue, Takuya, additional, Murano, Naoko, additional, Shindo, Yasunori, additional, Umegaki, Eiji, additional, and Higuchi, Kazuhide, additional

Published
2009
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48. W1580: Geranylgeranylacetone Protects Against NSAIDs-Induced Gastric and Small Intestinal Mucosal Injuries in Healthy Subjects: A Prospective Randomised Study Compared With Famotidine

Author

Eiji Umegaki, Eijiro Morita, Yukiko Yoda, Kazuhide Higuchi, Sadaharu Nouda, Satoshi Tokioka, Kumi Ishida, Mitsuyuki Murano, Takanori Kuramoto, and Toshihisa Takeuchi

Subjects
Famotidine, medicine.medical_specialty, business.industry, Internal medicine, Gastroenterology, medicine, Healthy subjects, Radiology, Nuclear Medicine and imaging, business, medicine.drug
Published
2010
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49. 1080g: A New Slenderized Self-Propelling Capsule Endoscope Enabled Observation of Porcine'S Intestine

Author

Eiji Umegaki, Kazuhide Higuchi, Hironori Nishihara, Kumi Ishida, Takanori Kuramoto, Kazuki Kakimoto, Takuya Inoue, Yasunori Shindo, Yosuke Abe, Sadaharu Nouda, Naotake Ohtsuka, Eijiro Morita, Ken Kawakami, and Mitsuyuki Murano

Subjects
Endoscope, business.industry, Gastroenterology, Medicine, Capsule, Radiology, Nuclear Medicine and imaging, business, Biomedical engineering
Published
2010
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50. W1593: Usefulness of Polyethylene Glycol Solution for Bowel Preparation Before Capsule Endoscopy in Patients With Obscure Gastrointestinal Bleeding

Author

Yukiko Yoda, Sadaharu Nouda, Eiji Umegaki, Eijiro Morita, Kazuhide Higuchi, Kumi Ishida, Ken Kawakami, Satoshi Tokioka, Toshihisa Takeuchi, Takanori Kuramoto, and Mitsuyuki Murano

Subjects
medicine.medical_specialty, business.industry, Gastroenterology, Polyethylene glycol, law.invention, chemistry.chemical_compound, chemistry, Capsule endoscopy, law, Internal medicine, Bowel preparation, Medicine, Radiology, Nuclear Medicine and imaging, In patient, business, Obscure gastrointestinal bleeding
Published
2010
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