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Your search keyword '"Gavini, Hemanth"' showing total 16 results
Start Over Author "Gavini, Hemanth" Journal gastroenterology (00165085)
16 results on '"Gavini, Hemanth"'

6. Risk Factors for Progression of Low-Grade Dysplasia in Patients With Barrett's Esophagus.

Author

Wani, Sachin, Falk, Gary W., Post, Jane, Yerian, Lisa, Hall, Matthew, Wang, Amy, Gupta, Neil, Gaddam, Srinivas, Singh, Mandeep, Singh, Vikas, Chuang, Keng–Yu, Boolchand, Vikram, Gavini, Hemanth, Kuczynski, John, Sud, Priti, Bansal, Ajay, Rastogi, Amit, Mathur, Sharad C., Young, Patrick, and Cash, Brooks

Subjects
DYSPLASIA, BARRETT'S esophagus, DISEASE progression, DISEASE risk factors, ADENOCARCINOMA, FOLLOW-up studies (Medicine), CONFIDENCE intervals, PATIENTS
Abstract

Background & Aims: Data vary on the progression of low-grade dysplasia (LGD) in patients with Barrett''s esophagus (BE); in patients with LGD, we investigated the incidence of high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC) and compared progression in patients with different forms of LGD (prevalent vs incident and multifocal vs unifocal). We assessed the effects of consensus diagnosis of LGD on progression rates to HGD and EAC among expert pathologists. Methods: In a multicenter outcomes project, 210 patients with BE and LGD (classified as incident, prevalent, or persistent) were included. Patients were followed up for an average of 6.2 years (959.6 patient-years). Persistent LGD was defined as detection of LGD on ≥2 consecutive occasions during the follow-up period and extent as either unifocal (LGD at one level of BE segment) or multifocal (>1 level). Histology specimens were reviewed by 2 blinded pathologists. Results: Six patients developed EAC (incidence of 0.44%/year), and 21 developed HGD (incidence of 1.6%/year). The incidence of the combination of HGD and EAC was 1.83%/year. There were no associations between presence of prevalent, incident, or persistent LGD and the extent of LGD with progression rates. Based on consensus diagnosis of 88 reviewed specimens, there was no difference in the progression of LGD to either EAC (the incidence based on analyses by the local pathologist was 0.18%/year, the incidence when there was agreement between the local and one central pathologist was 0.21%/year, and the incidence when all 3 pathologists were in agreement was 0.39%/year) or combined HGD and EAC (0.94%/year, 0.87%/year, and 0.84%/year, respectively). Conclusions: Overall, patients with BE and LGD have a low annual incidence of EAC, similar to nondysplastic BE. There are no risk factors for progression and there is significant interobserver variation in diagnosis, even among expert pathologists. [Copyright &y& Elsevier]

Published
2011
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8. Relationship Between Barrett's Esophagus (BE) Length and the Risk of High Grade Dysplasia (HGD) and Esophageal Adenocarcinoma (EAC) in Patients With Non Dysplastic Barrett's Esophagus Results From a Large Multicenter Cohort.

Author

Gaddam, Srinivas, Young, Patrick E., Alsop, Benjamin R., Gupta, Neil, Gavini, Hemanth, Higbee, April D., Wani, Sachin B., Singh, Mandeep, Rastogi, Amit, Bansal, Ajay, Cash, Brooks D., Lieberman, David A., Sampliner, Richard E., Falk, Gary W., and Sharma, Prateek

Published
2011
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9. Agreement Among Expert Gastrointestinal Pathologists for Low-Grade Dysplasia (LGD) in Barrett's Esophagus (BE) and Implications for Progression: Results From a Large, Multicenter Cohort Study.

Author

Wani, Sachin B., Goldblum, John R., Post, Jane, Gaddam, Srinivas, Gupta, Neil, Alsop, Benjamin R., Gavini, Hemanth, Rastogi, Amit, Higbee, April D., Young, Patrick E., Bansal, Ajay, Cash, Brooks D., Sampliner, Richard E., Lieberman, David A., Yerian, Lisa, Falk, Gary W., and Sharma, Prateek

Published
2011
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10. Is the Extent of Low-Grade Dysplasia (LGD) in Barrett's Esophagus (BE) a Risk Factor for the Development of Esophageal Adenocarcinoma (EAC): Results From a Large, Multicenter Cohort Study.

Author

Wani, Sachin B., Lieberman, David A., Gavini, Hemanth, Gupta, Neil, Yerian, Lisa, Gaddam, Srinivas, Post, Jane, Alsop, Benjamin R., Higbee, April D., Singh, Mandeep, Cash, Brooks D., Rastogi, Amit, Falk, Gary W., Bansal, Ajay, Goldblum, John R., Sampliner, Richard E., Young, Patrick E., and Sharma, Prateek

Published
2011
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11. W1051 Adherence to Surveillance Interval Guidelines in Barrett's Esophagus (BE): Analysis From a Large Multicenter Cohort Study.

Author

Gupta, Neil, Wang, Amy, Young, Patrick E., Wani, Sachin B., Bansal, Ajay, Chuang, Keng-Yu, Gavini, Hemanth, Boolchand, Vikram, Sud, Priti, Kuczynski, John, Gaddam, Srinivas, Singh, Vikas, Singh, Mandeep, Higbee, April D., Cash, Brooks D., Rastogi, Amit, Mathur, Sharad C., Lieberman, David A., Falk, Gary W., and Sampliner, Richard E.

Published
2010
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12. M1104 Predicting High-Grade Dysplasia (HGD) and Esophageal Adenocarcinoma (EAC) in Patients With Non-Dysplastic Barrett's Esophagus (BE): Results From a Large, Multicenter Cohort Study.

Author

Gaddam, Srinivas, Young, Patrick E., Wang, Amy, Bansal, Ajay, Gupta, Neil, Wani, Sachin B., Singh, Mandeep, Singh, Vikas, Chuang, Keng-Yu, Boolchand, Vikram, Gavini, Hemanth, Sud, Priti, Kuczynski, John, Higbee, April D., Rastogi, Amit, Mathur, Sharad C., Cash, Brooks D., Falk, Gary W., Sampliner, Richard E., and Sharma, Prateek

Published
2010
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13. S1056 The Prevalence of Dysplasia is Increasing in Patients With Newly Diagnosed Barrett's Esophagus (BE): Secular Trends From a Large, Multicenter, Cohort Study.

Author

Wani, Sachin B., Gupta, Neil, Wang, Amy, Young, Patrick E., Bansal, Ajay, Chuang, Keng-Yu, Boolchand, Vikram, Gavini, Hemanth, Sud, Priti, Kuczynski, John, Gaddam, Srinivas, Singh, Vikas, Singh, Mandeep, Reddymasu, Savio, Rastogi, Amit, Cash, Brooks D., Mathur, Sharad C., Higbee, April D., Sampliner, Richard E., and Lieberman, David A.

Published
2010
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14. 475c Low Risk of Developing Dysplasia and Esophageal Adenocarcinoma (EAC) in Patients With Non-Dysplastic Barrett's Esophagus (BE): Results From a Large, Multicenter, Cohort Study.

Author

Wani, Sachin B., Falk, Gary W., Hall, Matthew, Wang, Amy, Gupta, Neil, Singh, Mandeep, Gaddam, Srinivas, Singh, Vikas, Chuang, Keng-Yu, Boolchand, Vikram, Gavini, Hemanth, Kuczynski, John, Sud, Priti, Reddymasu, Savio, Bansal, Ajay, Rastogi, Amit, Mathur, Sharad C., Young, Patrick E., Cash, Brooks D., and Lieberman, David A.

Published
2010
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