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Your search keyword '"microsatellite stable"' showing total 11 results
Start Over Descriptor "microsatellite stable" Journal gastroenterology
11 results on '"microsatellite stable"'

1. Specific Mutations in APC, but Not Alterations in DNA Damage Response, Associate With Outcomes of Patients With Metastatic Colorectal Cancer

Author

Rona Yaeger, Subhiksha Nandakumar, Henry Walch, Sebastian Mondaca, Walid K. Chatila, and Nikolaus Schultz

Subjects
medicine.medical_specialty, Time Factors, DNA damage, Colorectal cancer, Adenomatous Polyposis Coli Protein, Clinical Decision-Making, DNA Mutational Analysis, Article, Antineoplastic Combined Chemotherapy Protocols, Overall survival, Biomarkers, Tumor, Medicine, Humans, Genetic Predisposition to Disease, Progression-free survival, Neoplasm Metastasis, Precision Medicine, Hepatology, Clinical pathology, business.industry, Hazard ratio, Gastroenterology, Wnt signaling pathway, medicine.disease, Progression-Free Survival, Phenotype, Microsatellite Stable, Drug Resistance, Neoplasm, Mutation, Cancer research, business, Colorectal Neoplasms, DNA Damage
Abstract

In an integrated genomic and clinical analysis, we evaluate the effects of Wnt and DNA damage response pathway alterations on metastatic colorectal cancer.

Published
2020

3. Su1998 Genomic Profile and Clinicopathological Analysis of Postcolonoscopy Colorectal Cancers: A Pilot Study

Author

Chantal le Clercq, Silvia Sanduleanu, Ad A.M. Masclee, Manon van Engeland, Gerrit A. Meijer, Iris D. Nagtegaal, Beatriz Carvalho, Evert van den Broek, Bauke Ylstra, Sara D de Vries, Daniëlle A.M. Heideman, Martijn Cordes, Nicole C.T. van Grieken, and Cornelis J. A. Punt

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Age at diagnosis, Microsatellite instability, medicine.disease_cause, medicine.disease, digestive system diseases, Log-rank test, Germline mutation, Microsatellite Stable, Internal medicine, medicine, In patient, KRAS, business, neoplasms, Methylator phenotype
Abstract

follow-up period (82,7 months). The study of methylator phenotype was possible in 543 patients (77,5%), with 146 CIMP+ (26,9%) and 397 CIMP(73,1%) patients. Some features between CIMP+ and CIMPCRCs were compared. CIMP+ showed a higher age at diagnosis (CIMP+ 72,8 [39-93]; CIMP70,8 [34-93]; p

Published
2015
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5. Su1900 Tumor Infiltrating Macrophages as a Potential Predictive Biomarker of Response to 5-FU in Patients With Microsatellite-Stable Colorectal Cancer

Author

Giuseppe Di Caro, Paolo Bianchi, Alberto Mantovani, Massimo Roncalli, Alberto Malesci, Fabio Grizzi, Luigi Laghi, and Giuseppe Celesti

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, Colorectal cancer, Tumor Infiltrating Macrophages, Gastroenterology, medicine.disease, Microsatellite Stable, Internal medicine, medicine, In patient, business, Predictive biomarker
Published
2012
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6. Identification of Mirnas and Their Gene Targets Differentially Expressed in Microsatellite Stable and Unstable Colorectal Cancers Through an Integrated Analysis

Author

Epicolon Investigators, Yang Dai, Ajay Goel, C. Richard Boland, Vanessa R. Sohn, Xavier Bessa, Rosa M. Xicola, Lei Huang, Rodrigo Jover, Angel Carracedo, Antoni Castells, Wenbo Mu, Brian J. Doyle, Xavier Llor, and Montserrat Andreu

Subjects
Hepatology, Gene targets, Microsatellite Stable, microRNA, Gastroenterology, Identification (biology), Computational biology, Biology
Published
2011
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7. S1982 Biallelic Pms2 Germline Mutations in a Family With a Microsatellite-Stable Brain Tumor and Early Onset Colorectal Cancer

Author

Celine H. Leenen, Anja Wagner, Monique E. van Leerdam, Ina R. Geurts-Giele, W. Dinjens, Erik Jan Dubbink, and Ernst J. Kuipers

Subjects
Oncology, medicine.medical_specialty, Hepatology, Colorectal cancer, business.industry, Gastroenterology, Brain tumor, Cancer, Mouse model of colorectal and intestinal cancer, medicine.disease, Germline mutation, Microsatellite Stable, Internal medicine, medicine, PMS2, business, Early onset
Published
2010
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8. 39 Stromal TWIST1 Expression Increases Together With Local Invasion in Microsatellite-Stable Colorectal Cancers

Author

Giuseppe Di Caro, Lucia Fini, Massimo Roncalli, Giuseppe Celesti, Fabio Grizzi, Luigi Laghi, Paolo Bianchi, and Alberto Malesci

Subjects
Oncology, medicine.medical_specialty, Stromal cell, Hepatology, Microsatellite Stable, Internal medicine, Gastroenterology, medicine, Cancer research, Biology, Mouse model of colorectal and intestinal cancer
Published
2010
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9. 39 Low-Density of CD3+ Cells At the Invasion Front and Increased Risk of Liver Metastases Development in Microsatellite-Stable Colorectal Cancer Patients

Author

Elena Miranda, Luigi Laghi, Massimo Roncalli, Emanuela Balladore, Alberto Mantovani, Alberto Malesci, and Paolo Bianchi

Subjects
Oncology, medicine.medical_specialty, Hepatology, biology, Colorectal cancer, business.industry, CD3, Gastroenterology, Cancer, medicine.disease, Increased risk, Microsatellite Stable, Internal medicine, medicine, biology.protein, Low density, business, Invasion front
Published
2008
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11. Presence of Twist1-positive neoplastic cells in the stroma of chromosome-unstable colorectal tumors.

Author

Celesti G, Di Caro G, Bianchi P, Grizzi F, Basso G, Marchesi F, Doni A, Marra G, Roncalli M, Mantovani A, Malesci A, and Laghi L

Subjects
Adenocarcinoma genetics, Adenocarcinoma pathology, Adenoma genetics, Adenoma pathology, Aged, Animals, Case-Control Studies, Cell Line, Tumor, Cell Transformation, Neoplastic genetics, Colorectal Neoplasms genetics, Colorectal Neoplasms pathology, Female, Gene Expression Regulation, Neoplastic, Genotype, Humans, Immunohistochemistry, In Situ Hybridization, Fluorescence, Male, Mice, Mice, Inbred BALB C, Mice, Knockout, Microsatellite Instability, Middle Aged, Neoplasm Invasiveness, Neoplasm Metastasis, Phenotype, Stromal Cells, Adenocarcinoma metabolism, Adenoma metabolism, Biomarkers, Tumor metabolism, Cell Transformation, Neoplastic metabolism, Colorectal Neoplasms metabolism, Nuclear Proteins metabolism, Twist-Related Protein 1 metabolism
Abstract

Background & Aims: Cancer cells undergo an epithelial-to-mesenchymal transition (EMT) to become invasive, allowing tumors to progress. However, there is no direct evidence that human cancer cells undergo an EMT. In mouse cancer cells, up-regulation of transcription factor Twist1 was shown to promote an EMT. We searched the stroma of human colorectal tumor samples for TWIST1-positive cells with a mesenchymal phenotype and neoplastic genotype., Methods: We measured the expression of TWIST1 in human colorectal cancer (CRC) cell lines and examined the effects of overexpression or knockdown in vitro and in mice. We used immunohistochemistry to measure levels of TWIST1 in 201 colorectal tumor samples. In 20 samples, immunostaining was combined with fluorescence in situ hybridization analyses. Levels of TWIST1 messenger RNA (mRNA) were measured in blood samples from 15 patients., Results: TWIST1 was required to maintain the mesenchymal phenotype and invasiveness of the microsatellite-stable CoLo741 cells (which express endogenous TWIST1) and SW480 (expressing transgenic TWIST1). TWIST1 mRNA was not translated in CRC cells with microsatellite instability (HCT116). Syngenic TWIST1-positive colon carcinoma cells (CT26) that invaded tissues surrounding tumors acquired a mesenchymal phenotype. The presence of TWIST1-positive cells in the stroma of human colorectal tumors correlated with microsatellite stability (P = .05), stage IV cancer (P = .02), and disease-free survival time (P < .01). Trisomies of chromosome 7 and/or chromosome 20 were detected in 17 of 20 colorectal tumor samples, each of which contained TWIST1-positive cells with matching chromosomal gains in the tumor stroma (86 of 776 counted cells; 11.1%). No trisomy was observed in TWIST1-negative stromal cells (0 of 1249 cells; P < .001). Levels of TWIST1 mRNA were significantly higher in blood samples from patients with CRC than controls., Conclusions: The stroma of human colorectal tumors contains TWIST1-positive cancer cells with mesenchymal phenotypes. Patients with CRC have higher levels of TWIST1 mRNA than healthy individuals., (Copyright © 2013 AGA Institute. Published by Elsevier Inc. All rights reserved.)

Published
2013
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