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modalities were included in this analysis. Patients who stopped EET and started surveillance prior to CE-IM were excluded. Complete eradication of intestinal metaplasia (CE-IM) was defined as having an endoscopy with no visible columnar lined epithelium in the tubular esophagus and biopsies of the neo-squamous mucosa showing no intestinal metaplasia. Patients were considered to have achieved CE-IM if they had done so with 2cm were less likely to achieve CE-IM compared to those with C extents ≤2cm (64.3% vs. 73.5%, p=0.027). Patients with M extents of > 3cm were less likely to achieve CE-IM compared to those with M extents ≤3cm (61.2% vs. 88.4%, p

BACKGROUNDA while patients with GERD (E+ and E-/pH+ groups) had significantly (p

G A A b st ra ct s NSAID use and erosive esophagitis and/or esophageal strictures. Most studies were published 10 years ago and significant heterogeneity was seen between studies. Limited data suggest that use of NSAIDs was not significantly increased in patients with esophageal injury compared with controls, with a magnitude of effect size smaller than that reported with gastroduodenal ulcers. More evidence is required to have a clearer picture of esophageal injury caused by NSAIDs.

Pure upright gastroesophageal reflux has not been treated surgically in the past because it was seen as physiologic and is associated with aerophagia which may lead to gas bloat, postoperatively. We have identified patients with esophageal injury resulting from upright reflux, and for the past three years have treated these patients similarly to supine and mixed refluxers. The purpose of this study was to determine the extent of esophageal injury and assess the operative outcome of patients undergoing antireflux procedures for pure upright reflux. METHODS: A prospective analysis of symptoms, esophageal function, and esophageal injury was performed in all surgically treated patients found to have pure upright reflux (reflux time >8.2% in upright position and - 3 months, but were noted only once a week and were easily relieved by medication and eructation. CONCLUSION: Pure uptight reflux can lead to esophageal mucosal injury. Operative therapy in patients with this condition is effective and can be accomplished with minimal morbidity. Postoperative gas bloat occurs with the same frequency in upright refluxers as it does in all others undergoing antireflux surgery.