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682 results on '"So, Takanori"'

1. Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis

Author

Naganuma, Makoto, Sugimoto, Shinya, Mizuno, Shinta, Nakazato, Yoshihiro, Fukuda, Tomohiro, Teratani, Toshiaki, Ogata, Haruhiko, Iwao, Yasushi, Kanai, Takanori, Yamasaki, Hiroshi, Mitsuyama, Keiichi, Kobayashi, Taku, Toyonaga, Takahiko, Nakano, Masaru, Hibi, Toshifumi, Yoshimura, Naoki, Sameshima, Yoichi, Ohi, Hidehisa, Hayashi, Ryohei, Ueno, Yoshitaka, Tanaka, Shinji, Bamba, Shigeki, Andoh, Akira, Matsuoka, Katsuyoshi, Watanabe, Mamoru, Saigusa, Keiichiro, Nakazawa, Atsushi, Morohoshi, Yuichi, Koike, Yuji, Imai, Jin, Ichikawa, Hitoshi, Shimoyama, Takahiro, Yamamoto, Takayuki, Takeuchi, Ken, Suzuki, Yasuo, Nagasaka, Mitsuo, Ohmiya, Naoki, Kitano, Atsuo, Ashizuka, Shinya, Inatsu, Haruhiko, Onodera, Kei, Nakase, Hiroshi, Kitamura, Kazuya, Ikeya, Kentaro, Hanai, Hiroyuki, Watanabe, Chikako, Hokari, Ryota, Hirai, Fumihito, Naito, Yuji, Hoshi, Namiko, Kinjo, Fukunori, Ishiguro, Yo, Sasaki, Makoto, Matsumoto, Takayuki, Watanabe, Kenji, Hisamatsu, Tadakazu, Sano, Fumiya, Roberts, Rachel, Abe, Takayuki, Suda, Wataru, Hattori, Masahira, Fukuda, Shinji, and Hirayama, Akiyoshi

Published
2018
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2. Identification of Quiescent LGR5+ Stem Cells in the Human Colon

Author

Ishikawa, Keiko, primary, Sugimoto, Shinya, additional, Oda, Mayumi, additional, Fujii, Masayuki, additional, Takahashi, Sirirat, additional, Ohta, Yuki, additional, Takano, Ai, additional, Ishimaru, Kazuhiro, additional, Matano, Mami, additional, Yoshida, Kosuke, additional, Hanyu, Hikaru, additional, Toshimitsu, Kohta, additional, Sawada, Kazuaki, additional, Shimokawa, Mariko, additional, Saito, Megumu, additional, Kawasaki, Kenta, additional, Ishii, Ryota, additional, Taniguchi, Koji, additional, Imamura, Takeshi, additional, Kanai, Takanori, additional, and Sato, Toshiro, additional

Published
2022
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3. Wnt Signaling Shapes the Histologic Variation in Diffuse Gastric Cancer

Author

Kazuhiro Togasaki, Yuki Ohta, Masayuki Fujii, Shinya Sugimoto, Mami Matano, Kosaku Nanki, Toshiro Sato, Sirirat Takahashi, and Takanori Kanai

Subjects
Male, 0301 basic medicine, Primary Cell Culture, Biology, Gene Knockout Techniques, Mice, 03 medical and health sciences, 0302 clinical medicine, Poorly cohesive carcinoma, Antigens, CD, Stomach Neoplasms, Cancer stem cell, Signet ring cell carcinoma, Exome Sequencing, Tumor Cells, Cultured, medicine, Organoid, Animals, Humans, RNA-Seq, Wnt Signaling Pathway, Aged, Hepatology, Gastroenterology, LGR5, Wnt signaling pathway, Cancer, Middle Aged, Cadherins, medicine.disease, Xenograft Model Antitumor Assays, Phenotype, Organoids, 030104 developmental biology, Gastric Mucosa, Cancer research, Female, 030211 gastroenterology & hepatology, Tumor Suppressor Protein p53, Thrombospondins, Carcinoma, Signet Ring Cell
Abstract

Background and Aims Diffuse-type gastric cancer (GC) is currently subdivided into signet-ring cell carcinoma (SRCC) and non-SRCC, referred to as poorly cohesive carcinoma not otherwise specified (PCC-NOS). Although these subtypes are considered to be independent, they often coexist in the same tumors, raising a question of whether they clonally differ or not. To tackle this question, we established an experimental platform for human diffuse GC that enables accurate modeling of histologic subtypes. Methods Seven patient-derived diffuse GC organoid lines were established, characterized by histopathologic analysis, in situ hybridization, and gene expression analysis. For genetic modeling of diffuse GC, we knocked out CDH1 and/or TP53 in human normal gastric organoids. Green fluorescent protein–labeled GC organoids were xenotransplanted into immune-deficient mice for in vivo assessment. Results PCC-NOS organoids transformed into SRCC-like structures on removal of Wnt and R-spondin from the culture medium. This morphologic change paralleled downregulation of Wnt-target and gastric stem cell genes, including LGR5, and elevation of differentiation markers, such as KRT20 and MUCs. The association between Wnt target gene expression and histologic subtypes was confirmed in 3 patient-derived GC tissues. In vivo, single clone-derived organoids formed tumors that comprised 2 distinct histologic compartments, each corresponding to SRCC and PCC-NOS. The transition from PCC-NOS to SRCC histology reflected the abundance of surrounding R-spondin–expressing fibroblasts. Conclusions SRCC and PCC-NOS were clonally identical, and their morphology was regulated by extracellular Wnt and R-spondin expression. Our results decoded how genetic mutations and the tumor environment shape pathohistologic and biologic phenotypes in human diffuse GCs.

Published
2021

8. Tu1310: NON-INVASIVE TESTS (NITS) FOR PREDICTING HEPATOCELLULAR CARCINOMA IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) PATIENTS WITHOUT CIRRHOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF INDIVIDUAL PATIENT DATA AND AGGREGATE DATA

Author

Siriwong, Nanicha, primary, Sriphoosanaphan, Supachaya, additional, Yongpisarn, Tanat, additional, Apiparakoon, Terapap, additional, Tiyarattanachai, Thodsawit, additional, Kerr, Stephen J., additional, Treeprasertsuk, Sombat, additional, Hagstrom, Hannes, additional, Akbari, Camilla, additional, Ekstedt, Mattias, additional, Ito, Takanori, additional, Ishigami, Masatoshi, additional, Toyoda, Hidenori, additional, Hino, Keisuke, additional, Kawanaka, Miwa, additional, sumida, yoshio, additional, Seko, Yuya, additional, Peleg, Noam, additional, Shlomai, Amir, additional, Yip, Terry Cheuk Fung, additional, Wong, Grace L., additional, and Chaiteerakij, Roongruedee, additional

Published
2022
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9. Sa1396: ANTIVIRAL THERAPY IMPROVES SURVIVAL IN VIRAL-ASSOCIATED HEPATOCELLULAR CARCINOMA AFTER LIVER RESECTION BUT IS SEVERELY UNDERUTILIZED

Author

Huang, Daniel, primary, Kamal, Rubayet, additional, Tsai, Pei-Chien, additional, Toyoda, Hidenori, additional, Yeh, Ming-Lun, additional, Yasuda, Satoshi, additional, Leong, Jennifer, additional, Hoang, Joseph, additional, Maeda, Mayumi, additional, Huang, Chung-Feng, additional, Jun, Dae Won, additional, Bonham, Andrew, additional, Ogawa, Eiichi, additional, Uojima, Haruki, additional, Abe, Hiroshi, additional, Hsu, Yao-Chun, additional, Tseng, Cheng-Hao, additional, Liu, Joanne, additional, Landis, Charles, additional, Dai, Chia-Yen, additional, Huang, Jee-Fu, additional, Chuang, Wan-Long, additional, Schwartz, Myron, additional, Dan, Yock Young, additional, Esquivel, Carlos O., additional, Yu, Ming-Lung, additional, Nguyen, Mindie H., additional, Suzuki, Takanori, additional, and Tanaka, Yasuhito, additional

Published
2022
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11. 446: PREDICTING OUTCOMES USING AN EARLY HOSPITALIZATION PANCREATITIS ACTIVITY SCORING SYSTEM: A LARGE PROSPECTIVE MULTICENTER STUDY

Author

Horibe, Masayasu, primary, Iwasaki, Eisuke, additional, Tsuji, Yoshihisa, additional, Toshihiko, Mayumi, additional, Sanui, Masamitsu, additional, Eguchi, Takaaki, additional, Emoto, Ken, additional, Oshima, Taku, additional, Yokota, Takuya, additional, Kayashima, Atsuto, additional, Yamamoto, Satoshi, additional, Izai, Junko, additional, Goto, Takashi, additional, Chiba, Nobutaka, additional, Ikeura, Tsukasa, additional, Miyata, Hiroaki, additional, Takeyama, Yoshifumi, additional, Okazaki, Kazuichi, additional, and Kanai, Takanori, additional

Published
2022
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12. EP1154: A NEW SCORING MODEL TO PREDICT AGGRESIVENESS OF PANCREATIC NEUROENDOCINE TUMORS USING PREOPERATIVE FACTORS

Author

Takikawa, Tetsuya, primary, Hamada, Shin, additional, Sasaki, Akira, additional, Kataoka, Humiya, additional, Ikeda, Mio, additional, Sano, Takanori, additional, Tanaka, Yu, additional, Matsumoto, Ryotaro, additional, Yoshida, Naoki, additional, Miura, Shin, additional, Kume, Kiyoshi, additional, Kikuta, Kazuhiro, additional, and Masamune, Atsushi, additional

Published
2022
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13. EP1152: THE M-ANNHEIM-AIP-ACTIVITY SCORE IS ASSOCIATED WITH RELAPSE OF TYPE 1 AUTOIMMUNE PANCREATITIS

Author

Sano, Takanori, primary, Kikuta, Kazuhiro, additional, Sasaki, Akira, additional, Kataoka, Humiya, additional, Ikeda, Mio, additional, Matsumoto, Ryotaro, additional, Tanaka, Yu, additional, Yoshida, Naoki, additional, Takikawa, Tetsuya, additional, Miura, Shin, additional, Hamada, Shin, additional, Kume, Kiyoshi, additional, and Masamune, Atsushi, additional

Published
2022
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16. Sa1616 MORTALITY RATES AMONG PATIENTS SUCCESSFULLY TREATED FOR HEPATITIS C: A REAL WORLD MULTINATIONAL COHORT STUDY

Author

Enomoto, Masaru, Ji, Fanpu, Ogawa, Eiichi, Suzuki, Takanori, Huang, Chung-Feng, Wong, Yu Jun, Toyoda, Hidenori, Tran, Sally, Chuma, Makoto, Uojima, Haruki, Atsukawa, Masanori, Hsu, Yao-Chun, Jun, Dae Won, Nozaki, Akito, Tseng, Cheng-Hao, Ishigami, Masatoshi, Honda, Takashi, Trinh, Huy N., Watanabe, Tsunamasa, Abe, Hiroshi, Preda, Carmen M., Lee, Dong-Hyun, Ishikawa, Toru, Haga, Hiroaki, Liang, Jing, Takahashi, Hirokazu, Landis, Charles, Li, Jia, Takaguchi, Koichi, Senoh, Tomonori, Huang, Rui, Wong, Grace L., Wong, Vincent Wai-Sun, Lam, Carla, Huang, Daniel, Keisuke, Yokohama, Asai, Akira, Ye, Qing, Itokawa, Norio, Nakamuta, Makoto, Nomura, Hideyuki, Kajiwara, Eiji, Azuma, Koichi, Dohmen, Kazufumi, Kawano, Akira, Koyanagi, Toshimasa, Ooho, Aritsune, Satoh, Takeaki, Takahashi, Kazuhiro, and Nguyen, Mindie H.

Published
2024
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20. Mo1228 ASSOCIATION OF DIRECT ORAL ANTICOAGULANT AND DELAYED BLEEDING WITH PHARMACOKINETICS AFTER ENDOSCOPIC SUBMUCOSAL DISSECTION

Author

Sugimoto, Mitsushige, Murata, Masaki, Nagami, Yasuaki, Ominami, Masaki, Sawaya, Manabu, Nakatani, Yasuki, Furumoto, Yohei, Dohi, Osamu, Sumiyoshi, Tetsuya, Fukuzawa, Masakatsu, Kagawa, Yasuyuki, Tsuji, Shigetsugu, Miyahara, Koji, Takeuchi, Yoji, Suzuki, Sho, Tominaga, Naoyuki, Yagi, Nobuaki, Osawa, Satoshi, Sakata, Yasuhisa, Yamada, Takanori, Yoshizawa, yashiro, Yamauchi, Atsushi, Yamamura, Takeshi, Gotoda, Takuji, Fujishiro, Mitsuhiro, and Kawai, Takashi

Published
2024
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22. Epithelium Replacement Contributes to Field Expansion of Squamous Epithelium and Ulcerative Colitis–Associated Neoplasia

Author

Sugimoto, Shinya, primary, Iwao, Yasushi, additional, Shimoda, Masayuki, additional, Takabayashi, Kaoru, additional, Sato, Toshiro, additional, Kanai, Takanori, additional, Mutaguchi, Makoto, additional, Nanki, Kosaku, additional, Okabayashi, Koji, additional, Kawaida, Miho, additional, Aoki, Yasuhiro, additional, Yoshimatsu, Yusuke, additional, Kiyohara, Hiroki, additional, Kawaguchi, Takaaki, additional, Mikami, Yohei, additional, Fukuhara, Kayoko, additional, Sujino, Tomohisa, additional, Hosoe, Naoki, additional, Ogata, Haruhiko, additional, and Yahagi, Naohisa, additional

Published
2022
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23. Identification of Quiescent LGR5

Author

Keiko, Ishikawa, Shinya, Sugimoto, Mayumi, Oda, Masayuki, Fujii, Sirirat, Takahashi, Yuki, Ohta, Ai, Takano, Kazuhiro, Ishimaru, Mami, Matano, Kosuke, Yoshida, Hikaru, Hanyu, Kohta, Toshimitsu, Kazuaki, Sawada, Mariko, Shimokawa, Megumu, Saito, Kenta, Kawasaki, Ryota, Ishii, Koji, Taniguchi, Takeshi, Imamura, Takanori, Kanai, and Toshiro, Sato

Subjects
Mice, Colon, Stem Cells, Transforming Growth Factors, Humans, Animals, Fluorouracil, Intestinal Mucosa, Receptors, G-Protein-Coupled
Abstract

In the mouse intestinal epithelium, Lgr5Transcriptional heterogeneity among colonic epithelial cells was analyzed by means of single-cell RNA sequencing analysis of human and mouse colonic epithelial cells. To trace the fate of human colonic stem or differentiated cells, we generated LGR5-tdTomato, LGR5-iCasase9-tdTomato, LGR5-split-Cre, and KRT20-ERCreER knock-in human colon organoids via genome engineering. p27Single-cell RNA sequencing analysis illuminated the presence of nondividing LGR5Our results highlight the quiescent nature of human LGR5

Published
2021

24. Identification of Quiescent LGR5+ Stem Cells in the Human Colon

Author

Keiko Ishikawa, Shinya Sugimoto, Mayumi Oda, Masayuki Fujii, Sirirat Takahashi, Yuki Ohta, Ai Takano, Kazuhiro Ishimaru, Mami Matano, Kosuke Yoshida, Hikaru Hanyu, Kohta Toshimitsu, Kazuaki Sawada, Mariko Shimokawa, Megumu Saito, Kenta Kawasaki, Ryota Ishii, Koji Taniguchi, Takeshi Imamura, Takanori Kanai, and Toshiro Sato

Subjects
Hepatology, Gastroenterology
Published
2022

26. Epithelium Replacement Contributes to Field Expansion of Squamous Epithelium and Ulcerative Colitis-Associated Neoplasia

Author

Shinya Sugimoto, Tomohisa Sujino, Yasushi Iwao, Makoto Mutaguchi, Kaoru Takabayashi, Yasuhiro Aoki, Toshiro Sato, Miho Kawaida, Koji Okabayashi, Naoki Hosoe, Takanori Kanai, Hiroki Kiyohara, Kayoko Fukuhara, Yohei Mikami, Naohisa Yahagi, Haruhiko Ogata, Kosaku Nanki, Yusuke Yoshimatsu, Takaaki Kawaguchi, and Masayuki Shimoda

Subjects
Pathology, medicine.medical_specialty, Hepatology, business.industry, Colon, Keratin-15, Gastroenterology, Rectum, Argon plasma coagulation, Epithelial Cells, Endoscopic submucosal dissection, medicine.disease, Ulcerative colitis, Epithelium, Mice, medicine.anatomical_structure, medicine, Animals, Keratins, Colitis, Ulcerative, Colitis-Associated Neoplasms, Intestinal Mucosa, Tumor Suppressor Protein p53, business, Cell Proliferation
Published
2021

28. Sa1396: ANTIVIRAL THERAPY IMPROVES SURVIVAL IN VIRAL-ASSOCIATED HEPATOCELLULAR CARCINOMA AFTER LIVER RESECTION BUT IS SEVERELY UNDERUTILIZED

Author

Daniel Huang, Rubayet Kamal, Pei-Chien Tsai, Hidenori Toyoda, Ming-Lun Yeh, Satoshi Yasuda, Jennifer Leong, Joseph Hoang, Mayumi Maeda, Chung-Feng Huang, Dae Won Jun, Andrew Bonham, Eiichi Ogawa, Haruki Uojima, Hiroshi Abe, Yao-Chun Hsu, Cheng-Hao Tseng, Joanne Liu, Charles Landis, Chia-Yen Dai, Jee-Fu Huang, Wan-Long Chuang, Myron Schwartz, Yock Young Dan, Carlos O. Esquivel, Ming-Lung Yu, Mindie H. Nguyen, Takanori Suzuki, and Yasuhito Tanaka

Subjects
Hepatology, Gastroenterology
Published
2022

29. 446: PREDICTING OUTCOMES USING AN EARLY HOSPITALIZATION PANCREATITIS ACTIVITY SCORING SYSTEM: A LARGE PROSPECTIVE MULTICENTER STUDY

Author

Masayasu Horibe, Eisuke Iwasaki, Yoshihisa Tsuji, Mayumi Toshihiko, Masamitsu Sanui, Takaaki Eguchi, Ken Emoto, Taku Oshima, Takuya Yokota, Atsuto Kayashima, Satoshi Yamamoto, Junko Izai, Takashi Goto, Nobutaka Chiba, Tsukasa Ikeura, Hiroaki Miyata, Yoshifumi Takeyama, Kazuichi Okazaki, and Takanori Kanai

Subjects
Hepatology, Gastroenterology
Published
2022

30. Tu1310: NON-INVASIVE TESTS (NITS) FOR PREDICTING HEPATOCELLULAR CARCINOMA IN NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) PATIENTS WITHOUT CIRRHOSIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF INDIVIDUAL PATIENT DATA AND AGGREGATE DATA

Author

Nanicha Siriwong, Supachaya Sriphoosanaphan, Tanat Yongpisarn, Terapap Apiparakoon, Thodsawit Tiyarattanachai, Stephen J. Kerr, Sombat Treeprasertsuk, Hannes Hagstrom, Camilla Akbari, Mattias Ekstedt, Takanori Ito, Masatoshi Ishigami, Hidenori Toyoda, Keisuke Hino, Miwa Kawanaka, yoshio sumida, Yuya Seko, Noam Peleg, Amir Shlomai, Terry Cheuk Fung Yip, Grace L. Wong, and Roongruedee Chaiteerakij

Subjects
Hepatology, Gastroenterology
Published
2022

34. Fr296 THE CHANGE OF PANCREATITIS ACTIVITY SCORING SYSTEM AND MORTALITY IN PROSPECTIVE LARGE MULTICENTER STUDY.

Author

Horibe, Masayasu, primary, Iwasaki, Eisuke, additional, Tsuji, Yoshihisa, additional, Sanui, Masamitsu, additional, Mayumi, Toshihiko, additional, Eguchi, Takaaki, additional, Goto, Takashi, additional, Kayashima, Atsuto, additional, Ikeura, Tsukasa, additional, Kitamura, Katsuya, additional, Yamamoto, Satoshi, additional, Emoto, Ken, additional, Kishino, Ryohei, additional, Yokota, Takuya, additional, Oshima, Taku, additional, Takeyama, Yoshifumi, additional, Okazaki, Kazuichi, additional, and Kanai, Takanori, additional

Published
2021
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35. Su252 SUPERIORITY OF URGENT VS. EARLY ENDOSCOPIC HEMOSTASIS IN PATIENTS WITH UPPER GASTROINTESTINAL BLEEDING

Author

Horibe, Masayasu, primary, Iwasaki, Eisuke, additional, Matsuzaki, Juntaro, additional, Bazerbachi, Fateh, additional, Kaneko, Tetsuji, additional, Minami, Kazuhiro, additional, Fukuhara, Seiichiro, additional, Masaoka, Tatsuhiro, additional, Hosoe, Naoki, additional, Ogura, Yuki, additional, Namiki, Shin, additional, Hosoda, Yasuo, additional, Ogata, Haruhiko, additional, and Kanai, Takanori, additional

Published
2021
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36. High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell-Derived Organoids

Author

Kyle Lewis, Shodai Togo, Yosuke Yoneyama, Ran-Ran Zhang, Wendy Thompson, Rie Ouchi, Andrew Dunn, Hiroyuki Koike, Yuqi Cai, Autumn Ferguson, Akihiro Asai, Masaki Kimura, Mari Maezawa, Takanori Takebe, Norikazu Saiki, and Tadahiro Shinozawa

Subjects
0301 basic medicine, Pluripotent Stem Cells, medicine.drug_class, Cell, Drug Evaluation, Preclinical, Biology, Cell Line, 03 medical and health sciences, 0302 clinical medicine, Cholestasis, medicine, Organoid, Toxicity Tests, Acute, Humans, Progenitor cell, Induced pluripotent stem cell, Hepatology, Bile acid, Gastroenterology, medicine.disease, High-Throughput Screening Assays, Organoids, 030104 developmental biology, medicine.anatomical_structure, Drug development, Liver, Hepatocyte, Cancer research, Hepatocytes, 030211 gastroenterology & hepatology, Chemical and Drug Induced Liver Injury
Abstract

Background & Aims Preclinical identification of compounds at risk of causing drug induced liver injury (DILI) remains a significant challenge in drug development, highlighting a need for a predictive human system to study complicated DILI mechanism and susceptibility to individual drug. Here, we established a human liver organoid (HLO)–based screening model for analyzing DILI pathology at organoid resolution. Methods We first developed a reproducible method to generate HLO from storable foregut progenitors from pluripotent stem cell (PSC) lines with reproducible bile transport function. The qRT-PCR and single cell RNA-seq determined hepatocyte transcriptomic state in cells of HLO relative to primary hepatocytes. Histological and ultrastructural analyses were performed to evaluate micro-anatomical architecture. HLO based drug-induced liver injury assays were transformed into a 384 well based high-speed live imaging platform. Results HLO, generated from 10 different pluripotent stem cell lines, contain polarized immature hepatocytes with bile canaliculi-like architecture, establishing the unidirectional bile acid transport pathway. Single cell RNA-seq profiling identified diverse and zonal hepatocytic populations that in part emulate primary adult hepatocytes. The accumulation of fluorescent bile acid into organoid was impaired by CRISPR-Cas9–based gene editing and transporter inhibitor treatment with BSEP. Furthermore, we successfully developed an organoid based assay with multiplexed readouts measuring viability, cholestatic and/or mitochondrial toxicity with high predictive values for 238 marketed drugs at 4 different concentrations (Sensitivity: 88.7%, Specificity: 88.9%). LoT positively predicts genomic predisposition (CYP2C9∗2) for Bosentan-induced cholestasis. Conclusions Liver organoid-based Toxicity screen (LoT) is a potential assay system for liver toxicology studies, facilitating compound optimization, mechanistic study, and precision medicine as well as drug screening applications.

Published
2020

38. High-Fidelity Drug-Induced Liver Injury Screen Using Human Pluripotent Stem Cell–Derived Organoids

Author

Shinozawa, Tadahiro, primary, Kimura, Masaki, additional, Cai, Yuqi, additional, Saiki, Norikazu, additional, Yoneyama, Yosuke, additional, Ouchi, Rie, additional, Koike, Hiroyuki, additional, Maezawa, Mari, additional, Zhang, Ran-Ran, additional, Dunn, Andrew, additional, Ferguson, Autumn, additional, Togo, Shodai, additional, Lewis, Kyle, additional, Thompson, Wendy L., additional, Asai, Akihiro, additional, and Takebe, Takanori, additional

Published
2021
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39. Mo1527 VIROLOGIC (VR), BIOCHEMICAL (BR), COMPLETE RESPONSE (CR) AND HEPATOCELLULAR CARCINOMA (HCC) INCIDENCE AMONG MALE AND FEMALE PATIENTS WITH CHRONIC HEPATITIS B (CHB) TREATED WITH NUCLEOS(T)IDES (NUC): A REAL-B STUDY

Author

Chau, Angela, Yeh, Ming-Lun, Tsai, Pei-Chien, Huang, Daniel, Kim, Sung Eun, Trinh, Huy N., Yoon, Eileen, Oh, Hyunwoo, Jeong, Jae Yoon, Ahn, Sang Bong, An, Jihyun, Tseng, Cheng-Hao, Hsu, Yao-Chun, Jeong, Soung Won, Cho, Yong Kyun, Shim, Jae-Jun, Kim, Hyoung-Su, Ito, Takanori, Marciano, Sebastian, Kawashima, Keigo, Watanabe, Tsunemasa, Nozaki, Akito, Ishikawa, Toru, Inoue, Kaori, Eguchi, Yuichiro, Uojima, Haruki, Abe, Hiroshi, Takahashi, Hirokazu, Chuma, Makoto, Ishigami, Masatoshi, Hoang, Joseph, Maeda, Mayumi, Huang, Chung-Feng, Gadano, Adrian, Dai, Chia-Yen, Huang, Jee-Fu, Tanaka, Yasuhito, Chuang, Wan-Long, Lim, Seng Gee, Jun, Dae Won, Yu, Ming-Lung, and Nguyen, Mindie H.

Published
2023
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43. Sa1354 THE VALIDATION OF PANCREATITIS ACTIVITY SCORING SYSTEM IN PROSPECTIVE LARGE MULTICENTER STUDY.

Author

Horibe, Masayasu, primary, Iwasaki, Eisuke, additional, Tsuji, Yoshihisa, additional, Sanui, Masamitsu, additional, Mayumi, Toshihiko, additional, Eguchi, Takaaki, additional, Kitamura, Katsuya, additional, Minami, Kazuhiro, additional, Ikeura, Tsukasa, additional, Chiba, Nobutaka, additional, Izai, Junko, additional, Suzuki, Hidetaka, additional, Yamamoto, Satoshi, additional, Kashiura, Masahiro, additional, Emoto, Ken, additional, Takeyama, Yoshifumi, additional, Okazaki, Kazuichi, additional, and Kanai, Takanori, additional

Published
2020
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44. Chromosome Engineering of Human Colon-Derived Organoids to Develop a Model of Traditional Serrated Adenoma

Author

Kawasaki, Kenta, primary, Fujii, Masayuki, additional, Sugimoto, Shinya, additional, Ishikawa, Keiko, additional, Matano, Mami, additional, Ohta, Yuki, additional, Toshimitsu, Kohta, additional, Takahashi, Sirirat, additional, Hosoe, Naoki, additional, Sekine, Shigeki, additional, Kanai, Takanori, additional, and Sato, Toshiro, additional

Published
2020
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45. Development of a Scalable Coculture System for Gut Anaerobes and Human Colon Epithelium

Author

Takanori Kanai, Nobuo Sasaki, Hiroshi Ohno, Kendle M. Maslowski, Toshiro Sato, and Kentaro Miyamoto

Subjects
Microbiological Techniques, Colon, Cell Culture Techniques, Green fluorescent protein, Microbiology, Bacteria, Anaerobic, Organoid, medicine, Humans, Intestinal Mucosa, Hepatology, biology, Gastrointestinal Microbiome, Gastroenterology, Cell hypoxia, Nutrients, biology.organism_classification, Epithelium, Cell Hypoxia, Coculture Techniques, Culture Media, Organoids, medicine.anatomical_structure, Human colon, Bacteria
Published
2019

47. Su252 SUPERIORITY OF URGENT VS. EARLY ENDOSCOPIC HEMOSTASIS IN PATIENTS WITH UPPER GASTROINTESTINAL BLEEDING

Author

Masayasu Horibe, Fateh Bazerbachi, Juntaro Matsuzaki, Seiichiro Fukuhara, Kazuhiro Minami, Takanori Kanai, Tetsuji Kaneko, Tatsuhiro Masaoka, Naoki Hosoe, Haruhiko Ogata, Eisuke Iwasaki, Yuki Ogura, Shin Namiki, and Yasuo Hosoda

Subjects
Endoscopic hemostasis, medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Medicine, In patient, Upper gastrointestinal bleeding, business, medicine.disease, Surgery
Published
2021

48. Fr296 THE CHANGE OF PANCREATITIS ACTIVITY SCORING SYSTEM AND MORTALITY IN PROSPECTIVE LARGE MULTICENTER STUDY

Author

Satoshi Yamamoto, Tsukasa Ikeura, Yoshihisa Tsuji, Toshihiko Mayumi, Atsuto Kayashima, Takaaki Eguchi, Masayasu Horibe, Ryohei Kishino, Takanori Kanai, Eisuke Iwasaki, Yoshifumi Takeyama, Kazuichi Okazaki, Takashi Goto, Ken Emoto, Taku Oshima, Takuya Yokota, Masamitsu Sanui, and Katsuya Kitamura

Subjects
medicine.medical_specialty, Scoring system, Hepatology, Multicenter study, business.industry, Internal medicine, Gastroenterology, Medicine, Pancreatitis, business, medicine.disease
Published
2021

49. Sa1354 THE VALIDATION OF PANCREATITIS ACTIVITY SCORING SYSTEM IN PROSPECTIVE LARGE MULTICENTER STUDY

Author

Yoshihisa Tsuji, Takaaki Eguchi, Hidetaka Suzuki, Satoshi Yamamoto, Kazuhiro Minami, Masamitsu Sanui, Eisuke Iwasaki, Katsuya Kitamura, Ken Emoto, Kazuichi Okazaki, Yoshifumi Takeyama, Tsukasa Ikeura, Nobutaka Chiba, Masahiro Kashiura, Toshihiko Mayumi, Takanori Kanai, Junko Izai, and Masayasu Horibe

Subjects
medicine.medical_specialty, Scoring system, Hepatology, Multicenter study, business.industry, Internal medicine, Gastroenterology, medicine, Pancreatitis, business, medicine.disease
Published
2020

50. Su1391 EFFICACY AND SAFETY OF VONOPRAZAN, SITAFLOXACIN AND METRONIDAZOLE CONTAINING REGIMEN FOR HELICOBACTER PYLORI ERADICATION IN PATIENTS WITH PENICILLIN ALLERGY

Author

Hideki Mori, Tatsuhiro Masaoka, Masahiro Yoshioka, Takanori Kanai, Juntaro Matsuzaki, Hidekazu Suzuki, Kazumi Inokuchi, and Akira Okazawa

Subjects
Sitafloxacin, medicine.medical_specialty, Hepatology, biology, business.industry, Vonoprazan, Gastroenterology, Penicillin allergy, Helicobacter pylori, biology.organism_classification, Metronidazole, Regimen, Internal medicine, medicine, In patient, business, medicine.drug
Published
2020

Catalog

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