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Your search keyword '"Phillip J Dexheimer"' showing total 12 results
Start Over Author "Phillip J Dexheimer" Journal gastroenterology
12 results on '"Phillip J Dexheimer"'

1. Su094 IMMUNE AND METABOLIC PATHOGENESIS OF ENVIRONMENTAL ENTERIC DYSFUNCTION IN CHILDHOOD UNDERNUTRITION: A BIRTH INCEPTION COHORT

Author

Najeeb U. Rehman, Asad Ali, Jennie Z. Ma, Rotem Hadar, Fayaz Umrani, Sean R. Moore, Sana Syed, Phillip J. Dexheimer, Romana Idrees, Aneeta Hotwani, Christopher A. Moskaluk, Sudhir Ghandikota, Anil G. Jegga, Junaid Iqbal, Kamran Sadiq, Tzipi Braun, Greg L Medlock, Zubair Ahmad, Lee A. Denson, Sheraz Ahmed, Indika Mallawaarachchi, Najeeha Talat Iqbal, Lubaina Ehsan, and Yael Haberman

Subjects
Pathogenesis, Malnutrition, Immune system, Hepatology, business.industry, Immunology, Gastroenterology, Medicine, business, medicine.disease, INCEPTION COHORT, AGA Abstracts
Published
2021
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2. Mucosal Genomics Implicate Lymphocyte Activation and Lipid Metabolism in Refractory Environmental Enteric Dysfunction

Author

Sheraz Ahmed, Najeeha Talat Iqbal, Lubaina Ehsan, Yael Haberman, Sean R. Moore, Zubair Ahmad, Jennie Z. Ma, Anil G. Jegga, Fayyaz Umrani, Phillip J. Dexheimer, Rotem Hadar, Najeeb Rahman, Junaid Iqbal, Sudhir Ghandikota, Greg L Medlock, Kamran Sadiq, Aneeta Hotwani, Indika Mallawaarachchi, Romana Idress, Lee A. Denson, Syed Asad Ali, Tzipi Braun, Sana Syed, and Chris Moskaluk

Subjects
Leptin, Male, 0301 basic medicine, IGF, insulin-like growth factor, Anthropometrics, medicine.medical_treatment, Lymphocyte proliferation, Lymphocyte Activation, Transcriptome, Epigenome, Insulin-like growth factor, Child Development, Full Report: Basic and Translational—Alimentary Tract, DMRs, differentially methylated regions, 0302 clinical medicine, SEEM, Study of Environmental Enteropathy and Malnutrition, IFNG, interferon gamma, Pakistan, Lymphocytes, Ctl, control, Insulin-Like Growth Factor I, Intestinal Mucosa, Wasting, Growth Disorders, Original Research, RNA Sequencing, DNAm, DNA methylation, HAZ, length/height-for-age z score, WGCNA, weighted gene coexpression network analysis, mRNAseq, messenger RNA, Gastroenterology, Genomics, Intestine, Child, Preschool, Creatinine, Female, 030211 gastroenterology & hepatology, medicine.symptom, FDR, false discovery rate, EED, environmental enteric dysfunction, Biology, AKU, Aga Khan University, 03 medical and health sciences, Immune system, CRFs, conditional random forests, medicine, Humans, Cell Proliferation, rDMR, regulatory DMR, Environmental enteropathy, Hepatology, Malnutrition, Infant, Newborn, Infant, Lipid metabolism, DNA Methylation, Lipid Metabolism, medicine.disease, Celiac Disease, Intestinal Diseases, Oxidative Stress, 030104 developmental biology, WAZ, weight-for-age z score, Case-Control Studies, Ferritins, Immunology, WHZ, weight-for- length/height z score, Biomarkers
Abstract

Background & Aims Environmental enteric dysfunction (EED) limits the Sustainable Development Goals of improved childhood growth and survival. We applied mucosal genomics to advance our understanding of EED. Methods The Study of Environmental Enteropathy and Malnutrition (SEEM) followed 416 children from birth to 24 months in a rural district in Pakistan. Biomarkers were measured at 9 months and tested for association with growth at 24 months. The duodenal methylome and transcriptome were determined in 52 undernourished SEEM participants and 42 North American controls and patients with celiac disease. Results After accounting for growth at study entry, circulating insulin-like growth factor-1 (IGF-1) and ferritin predicted linear growth, whereas leptin correlated with future weight gain. The EED transcriptome exhibited suppression of antioxidant, detoxification, and lipid metabolism genes, and induction of anti-microbial response, interferon, and lymphocyte activation genes. Relative to celiac disease, suppression of antioxidant and detoxification genes and induction of antimicrobial response genes were EED-specific. At the epigenetic level, EED showed hyper-methylation of epithelial metabolism and barrier function genes, and hypo-methylation of immune response and cell proliferation genes. Duodenal coexpression modules showed association between lymphocyte proliferation and epithelial metabolic genes and histologic severity, fecal energy loss, and wasting (weight-for-length/height Z < -2.0). Leptin was associated with expression of epithelial carbohydrate metabolism and stem cell renewal genes. Immune response genes were attenuated by giardia colonization. Conclusions Children with reduced circulating IGF-1 are more likely to experience stunting. Leptin and a gene signature for lymphocyte activation and dysregulated lipid metabolism are implicated in wasting, suggesting new approaches for EED refractory to nutritional intervention. ClinicalTrials.gov, Number: NCT03588013. (https://clinicaltrials.gov/ct2/show/NCT03588013), Graphical abstract

Published
2021
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3. 935 PRE-TREATMENT MUCOSAL INFLAMMATORY AND WOUND HEALING GENE PROGRAMS REVEAL MECHANISMS ASSOCIATED WITH FUTURE STRICTURING BEHAVIOR DURING FIVE YEAR FOLLOW-UP IN PEDIATRIC CROHN'S DISEASE

Author

Robert N. Baldassano, Greg Gibson, David Ziring, Lee A. Denson, Michael C. Stephens, Rebekah Karns, Susan S. Baker, David R. Mack, Phillip Minar, Anne M. Griffiths, Ajay S. Gulati, Dedrick E. Moulton, Melvin B. Heyman, Jeffrey S. Hyams, Daniel Shapiro, Richard Kellermayer, Scott B. Snapper, Anthony R. Otley, Joshua D. Noe, Bruce J. Aronow, Marla Dubinsky, Ashish Patel, Neal S. Leleiko, Yael Haberman, Jennifer L. Dotson, Anil G. Jegga, Sudhir Ghandikota, Maria Oliva-Hemker, Ranjana Gokhale, Stephen L. Guthery, Sandra C. Kim, Steven J. Steiner, Stanley A. Cohen, Phillip J. Dexheimer, James Markowitz, Suresh Venkateswaran, Subra Kugathasan, Thomas D. Walters, Samuel Tegge, Brianne Shuler, and Tzipi Braun

Subjects
Pre treatment, medicine.medical_specialty, Hepatology, Pediatric Crohn's disease, business.industry, Internal medicine, Gastroenterology, Five year follow up, medicine, business, Wound healing
Published
2020
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4. Tu1756 – The Treatment Naive Rectal Transcriptome Identifies Pathways Underlying Response to Induction Corticosteroid Therapy in Ulcerative Colitis

Author

Greg Gibson, Anne M. Griffiths, Melanie Schirmer, Alison Marquis, Thomas D. Walters, Curtis Huttenhower, Kevin P. Mollen, Joshua D. Noe, Sonia Davis Thomas, Margaret H. Collins, Paul A. Rufo, Brendan M. Boyle, Phillip J. Dexheimer, Cary G. Sauer, James Markowitz, Ashish S. Patel, Sapana Shah, Bruce J. Aronow, Melvin B. Heyman, Michael J. Rosen, Nathan Gotman, Angela Mo, Yael Haberman, Rebekah Karns, Lee A. Denson, Susan S. Baker, David R. Mack, Ingrid Jurickova, Subra Kugathasan, Ramnik J. Xavier, Marian D. Pfefferkorn, Joel R. Rosh, Neal S. Leleiko, Erin Bonkowski, Robert N. Baldassano, and Jeffrey S. Hyams

Subjects
Therapy naive, Transcriptome, Hepatology, Corticosteroid therapy, business.industry, Immunology, Gastroenterology, medicine, medicine.disease, business, Ulcerative colitis
Published
2019
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5. 740 - Age-of-Onset Dependent Ileal Immune Maturation and Reduced Alpha-Defensin in Pediatric Crohn Disease with Already Established Dysbiosis

Author

Marla Dubinsky, David Ziring, Robert N. Baldassano, Lee A. Denson, Scott B. Snapper, Barbara S. Kirschner, Rebekah Karns, Tzipi Braun, Stanley N. Cohen, Joshua D. Noe, Anthony R. Otley, Melanie Schirmer, Dedrick E. Moulton, Phillip J. Dexheimer, James Markowitz, Anne M. Griffiths, Yael Haberman, Richard Kellermayer, Thomas D. Walters, Susan S. Baker, David R. Mack, Curtis Huttenhower, Ashish S. Patel, Maria Oliva-Hemker, Jonathan P. Evans, Ajay S. Gulati, Joel R. Rosh, David J. Keljo, Wallace Crandall, Subra Kugathasan, Bruce J. Aronow, Stephen L. Guthery, Melvin B. Heyman, Steven J. Steiner, Mi-Ok Kim, Jeffrey S. Hyams, Ramnik J. Xavier, and Neal S. Leleiko

Subjects
Immune system, Hepatology, business.industry, Crohn disease, Immunology, Gastroenterology, medicine, Age of onset, medicine.disease, business, Dysbiosis, Alpha defensin
Published
2018
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6. 589 - The Treatment Naive Rectal Transcriptome Identifies Pathways Mediating Clinical and Endoscopic Severity and Response to Initial Therapy in Pediatric Ulcerative Colitis

Author

Erin Bonkowski, Joshua D. Noe, Robert N. Baldassano, Phillip J. Dexheimer, Thomas D. Walters, James Markowitz, Melvin B. Heyman, Rebekah Karns, Laura Bauman, Michael J. Rosen, Sonia M. Davis, Neal S. Leleiko, Joel R. Rosh, Cary G. Sauer, David J. Keljo, Bruce J. Aronow, Margaret H. Collins, Brendan M. Boyle, Jeffrey S. Hyams, Subra Kugathasan, Ashish Patel, Yael Haberman, Alison Marquis, Lee A. Denson, Marian D. Pfefferkorn, Susan S. Baker, David R. Mack, Paul A. Rufo, Anne M. Griffiths, and Nathan Gotman

Subjects
Oncology, Therapy naive, Transcriptome, medicine.medical_specialty, Hepatology, business.industry, Internal medicine, Gastroenterology, medicine, Pediatric ulcerative colitis, business, Initial therapy
Published
2018
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7. Sa2009 - Bioavailable Serum Vitamin D and Rectal Vitamin D Receptor Expression at Diagnosis in Pediatric Ulcerative Colitis: Associations with Disease Severity, Clinical Outcomes, and Rectal Patterns of Gene Expression

Author

Erin Bonkowski, Sonia M. Davis, Nathan Gotman, Phillip J. Dexheimer, James Markowitz, Brendan M. Boyle, Anne M. Griffiths, Ashish Patel, Cary G. Sauer, Susan S. Baker, David R. Mack, Margaret H. Collins, Melvin B. Heyman, Laura Bauman, Subra Kugathasan, Shiven Patel, Joel R. Rosh, Robert N. Baldassano, Rebekah Karns, Li Hao, Marian D. Pfefferkorn, Alison Marquis, Paul A. Rufo, Vin Tangpricha, Michael J. Rosen, Thomas D. Walters, Neal S. Leleiko, Yael Haberman, Joshua D. Noe, Lee A. Denson, David J. Keljo, Bruce J. Aronow, and Jeffrey S. Hyams

Subjects
Serum vitamin, medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, Pediatric ulcerative colitis, Calcitriol receptor, Bioavailability, Disease severity, Internal medicine, Gene expression, medicine, business
Published
2018
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8. Higher Mucosal Calprotectin Expression is Associated with Induction of Antimicrobial and Tumor Necrosis Factor Alpha Signaling and Reduced Effectiveness of Corticosteroid Therapy in Treatment Naive Pediatric Ulcerative Colitis

Author

Robert N. Baldassano, Nathan Gotman, Yael Haberman, Erin Bonkowski, Phillip J. Dexheimer, Susan S. Baker, James Markowitz, David R. Mack, Joel R. Rosh, Paul A. Rufo, Marian D. Pfefferkorn, Melvin B. Heyman, Jeffrey S. Hyams, Lee A. Denson, David J. Keljo, Bruce J. Aronow, Alison Marquis, Sonia M. Davis, Neal S. Leleiko, Ashish S. Patel, Anne M. Griffiths, Subra Kugathasan, Brendan M. Boyle, Cary G. Sauer, Thomas D. Walters, Courtney McCall, and Joshua D. Noe

Subjects
Therapy naive, Hepatology, Corticosteroid therapy, business.industry, Immunology, Gastroenterology, Medicine, Pediatric ulcerative colitis, Tumor necrosis factor alpha, Calprotectin, business, Antimicrobial
Published
2017
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9. Reduced Transcription of Genes Regulating Mitochondrial Biogenesis is Associated with Poor Response to Corticosteroid Therapy in Newly Diagnosed Pediatric Ulcerative Colitis

Author

Jeffrey S. Hyams, Erin Bonkowski, Marian D. Pfefferkorn, Phillip J. Dexheimer, Alison Marquis, Paul A. Rufo, James Markowitz, Anne M. Griffiths, Neal S. Leleiko, Melvin B. Heyman, Susan S. Baker, Robert N. Baldassano, David R. Mack, Cary G. Sauer, Brendan M. Boyle, David J. Keljo, Nathan Gotman, Bruce J. Aronow, Thomas D. Walters, Yael Haberman, Joel R. Rosh, Ashish S. Patel, Subra Kugathasan, Sonia M. Davis, Lee A. Denson, Courtney McCall, and Joshua D. Noe

Subjects
Hepatology, Mitochondrial biogenesis, Corticosteroid therapy, Transcription (biology), business.industry, Immunology, Gastroenterology, Pediatric ulcerative colitis, Medicine, Newly diagnosed, business, Gene
Published
2017
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10. 78 Host Ileal APOA1 and DUOX2 Co-Expression Modules Are Associated With Microbial Shifts and Clinical Outcomes in Treatment Naive Pediatric Crohn Disease

Author

Yael Haberman, Thomas D. Walters, Wallace Crandall, Curtis Huttenhower, Anne M. Griffiths, Bruce J. Aronow, Joshua D. Noe, Jeffrey S. Hyams, Robert N. Baldassano, Lee A. Denson, Susan S. Baker, David R. Mack, Ramnik J. Xavier, Joel R. Rosh, Timothy L. Tickle, Dirk Gevers, Melvin B. Heyman, Phillip J. Dexheimer, James Markowitz, Subra Kugathasan, and Rebekah Karns

Subjects
Therapy naive, Hepatology, Crohn disease, Host (biology), business.industry, Immunology, Gastroenterology, Medicine, business
Published
2014
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11. Mo1975 Ileal RNA-Seq Analyses Reveal Decreased Mucosal Myeloid Cell Immune Responses in Pediatric Crohn Disease Patients With Phagocyte Dysfunction Due to Neutralizing Granulocyte Macrophage Colony Stimulating Factor (GMCSF) Auto-Antibodies

Author

Erin Bonkowski, Dora Tang, Wallace Crandall, Melvin B. Heyman, Joshua D. Noe, Joel R. Rosh, Anthony R. Otley, Marian D. Pfefferkorn, Phillip J. Dexheimer, Michael D. Kappelman, James Markowitz, Yael Haberman, Barbara S. Kirschner, Lee A. Denson, Scott B. Snapper, Stanley A. Cohen, Robert N. Baldassano, Rebekah Karrns, Ashish S. Patel, Richard Kellermayer, Bruce J. Aronow, Thomas D. Walters, Benjamin Fey, Ingrid Jurrickova, and Marla Dubinsky

Subjects
Myeloid, Hepatology, Phagocyte, Crohn disease, Cell, Gastroenterology, Autoantibody, RNA-Seq, Biology, medicine.anatomical_structure, Granulocyte macrophage colony-stimulating factor, Immune system, Immunology, medicine, medicine.drug
Published
2013
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12. 834 Ileal Transcriptome Analysis Reveals Mucosal Immune Maturation With Increasing Age-of-Onset in Pediatric Crohn Disease and Healthy Controls - A Mucosal Gene Expression Based Signature That Supports the Paris Classification for Age-of-Onset

Author

Lee A. Denson, Jonathan P. Evans, Phillip J. Dexheimer, Marla Dubinsky, Dora Tang, Erin Bonkowski, Dedrick E. Moulton, David Ziring, Jeffrey S. Hyams, Rebekah Karns, Yael Haberman, Anne M. Griffiths, Neal S. Leleiko, Benjamin Fey, Stephen L. Guthery, Thomas D. Walters, Maria Oliva-Hemker, Subra Kugathasan, David J. Keljo, Bruce J. Aronow, Susan S. Baker, and David R. Mack

Subjects
Hepatology, Gastroenterology, Clostridium difficile toxin A, Clostridium difficile toxin B, Biology, Asymptomatic, digestive system diseases, Immunoglobulin G, Carriage, Immune system, Immunology, biology.protein, medicine, Age of onset, medicine.symptom, Feces
Abstract

matched controls without IBD. Information including diagnosis, IBD type, IBD activity, IBD medications, proton pump inhibitor (PPI) use, hospitalizations and antibiotic use was recorded. Patients were followed with repeat fecal and serum samples obtained. Cytotoxic culture for CD along with PCR to detect the toxin B gene was conducted on stool. Pulsed field gel electrophoresis (PFGE) was performed to determine strain type. Enzyme-linked Immunosorbent Assay (ELISA) was used to determine immunoglobulin G, A andM responses to CD toxin A and B from serum. Results: The prevalence of CD carriage was significantly greater in patients with IBD (17%) compared with controls (3%) (p=0.012). PCR to detect the toxin B gene compared to the gold standard of cytotoxic culture had a sensitivity of 92% and specificity of 100%. No patients showed clinical evidence of active CD infection. Among patients with IBD, IBD type, disease activity, IBD therapy, antibiotic use and hospitalizations were not found to be associated with CD carriage. PPI use was significantly more frequent in patients with CD carriage (54% vs. 25%, p,0.05). PFGE identified 6 different North American Pulsed Field Type (NAP) strains that then varied over time. There was a significantly greater proportion of patients with a positive antibody response to toxin A with IBD (69%) vs. controls (53%) (p,0.05), with a parallel trend of increased IgG and IgA responses against both toxin A and toxin B in those with IBD. Conclusions: Our findings show that asymptomatic toxigenic CD carriage, likely acquired in the community, is increased in pediatric IBD outpatients compared with controls. A variety of NAP strains were identified and these changed over time in CD colonized patients. PPI use was associated with an increased risk of carriage. Antibody responses of patients with IBD to CD toxins were increased, potentially promoting asymptomatic colonization. Future studies are needed to identify risk factors for symptomatic CD in pediatric IBD.

Published
2013
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