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1. No Difference in Colorectal Cancer Incidence or Stage at Detection by Colonoscopy Among 3 Countries With Different Lynch Syndrome Surveillance Policies

Author

Engel, Christoph, Vasen, Hans F., Seppälä, Toni, Aretz, Stefan, Bigirwamungu-Bargeman, Marloes, de Boer, Sybrand Y., Bucksch, Karolin, Büttner, Reinhard, Holinski-Feder, Elke, Holzapfel, Stefanie, Hüneburg, Robert, Jacobs, Maarten A.J.M., Järvinen, Heikki, Kloor, Matthias, von Knebel Doeberitz, Magnus, Koornstra, Jan J., van Kouwen, Mariette, Langers, Alexandra M., van de Meeberg, Paul C., Morak, Monika, Möslein, Gabriela, Nagengast, Fokko M., Pylvänäinen, Kirsi, Rahner, Nils, Renkonen-Sinisalo, Laura, Sanduleanu, Silvia, Schackert, Hans K., Schmiegel, Wolff, Schulmann, Karsten, Steinke-Lange, Verena, Strassburg, Christian P., Vecht, Juda, Verhulst, Marie-Louise, de Vos tot Nederveen Cappel, Wouter, Zachariae, Silke, Mecklin, Jukka-Pekka, and Loeffler, Markus

Published
2018
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2. Histologic Factors Associated With Need for Surgery in Patients With Pedunculated T1 Colorectal Carcinomas

Author

Backes, Yara, Elias, Sjoerd G., Groen, John N., Schwartz, Matthijs P., Wolfhagen, Frank H.J., Geesing, Joost M.J., ter Borg, Frank, van Bergeijk, Jeroen, Spanier, Bernhard W.M., de Vos tot Nederveen Cappel, Wouter H., Kessels, Koen, Seldenrijk, Cornelis A., Raicu, Mihaela G., Drillenburg, Paul, Milne, Anya N., Kerkhof, Marjon, Seerden, Tom C.J., Siersema, Peter D., Vleggaar, Frank P., Offerhaus, G. Johan A., Lacle, Miangela M., and Moons, Leon M.G.

Published
2018
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3. Su1654: CT-COLONOGRAPHY IN FECAL IMMUNOCHEMICAL TEST POSITIVE PATIENTS IN A COLORECTAL CANCER SCREENING PROGRAM - YIELD AND INCIDENCE OF INTERVAL CARCINOMAS

Author

Moen, Sarah, primary, Marijnissen, Fleur E., additional, Droste, Jochim S. Terhaar Sive, additional, Cappel, Wouter De Vos Tot Nederveen, additional, Spanier, B.W. Marcel, additional, Huisman, Jelle F., additional, Dekker, Evelien, additional, Stoker, Jaap, additional, Kuipers, Ernst J., additional, Thomeer, Maarten G., additional, and Spaander, Manon, additional

Published
2022
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4. One to 2-Year Surveillance Intervals Reduce Risk of Colorectal Cancer in Families With Lynch Syndrome

Author

Vasen, Hans F.A., Abdirahman, Mohamed, Brohet, Richard, Langers, Alexandra M.J., Kleibeuker, Jan H., van Kouwen, Mariette, Koornstra, Jan Jacob, Boot, Henk, Cats, Annemieke, Dekker, Evelien, Sanduleanu, Silvia, Poley, Jan–Werner, Hardwick, James C.H., de Vos tot Nederveen Cappel, Wouter H., van der Meulen–de Jong, Andrea E., Tan, T. Gie, Jacobs, Maarten A.J.M., Mohamed, Faig Lall A., de Boer, Sijbrand Y., van de Meeberg, Paul C., Verhulst, Marie–Louise, Salemans, Jan M., van Bentem, Nico, Westerveld, B. Dik, Vecht, Juda, and Nagengast, Fokko M.

Published
2010
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8. Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome

Author

Engel, Christoph, primary, Ahadova, Aysel, additional, Seppälä, Toni T., additional, Aretz, Stefan, additional, Bigirwamungu-Bargeman, Marloes, additional, Bläker, Hendrik, additional, Bucksch, Karolin, additional, Büttner, Reinhard, additional, de Vos tot Nederveen Cappel, Wouter T., additional, Endris, Volker, additional, Holinski-Feder, Elke, additional, Holzapfel, Stefanie, additional, Hüneburg, Robert, additional, Jacobs, Maarten A.J.M., additional, Koornstra, Jan J., additional, Langers, Alexandra M., additional, Lepistö, Anna, additional, Morak, Monika, additional, Möslein, Gabriela, additional, Peltomäki, Päivi, additional, Pylvänäinen, Kirsi, additional, Rahner, Nils, additional, Renkonen-Sinisalo, Laura, additional, Schulmann, Karsten, additional, Steinke-Lange, Verena, additional, Stenzinger, Albrecht, additional, Strassburg, Christian P., additional, van de Meeberg, Paul C., additional, van Kouwen, Mariette, additional, van Leerdam, Monique, additional, Vangala, Deepak B., additional, Vecht, Juda, additional, Verhulst, Marie-Louise, additional, von Knebel Doeberitz, Magnus, additional, Weitz, Jürgen, additional, Zachariae, Silke, additional, Loeffler, Markus, additional, Mecklin, Jukka-Pekka, additional, Kloor, Matthias, additional, and Vasen, Hans F., additional

Published
2020
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9. Su054 YIELD OF CT COLONOGRAPHY IN FIT POSITIVE INDIVIDUALS IN THE DUTCH BOWEL CANCER SCREENING PROGRAM, A 4 YEARS MULTICENTER EXPERIENCE

Author

Marie Louise Bernsen, Wouter H. de Vos tot Nederveen Cappel, Marieke H A Lammertink, Marcel Spanier, Ronald A M Niekel, Erik van Westreenen, and Jelle F. Huisman

Subjects
medicine.medical_specialty, Hepatology, Colorectal cancer, business.industry, Yield (finance), Gastroenterology, medicine, Radiology, medicine.disease, business
Published
2021
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10. Sa1635 CINE-MRI VERSUS COLONIC MANOMETRY IN THE ASSESSMENT OF COLON MOTILITY IN CHILDREN WITH FUNCTIONAL CONSTIPATION: A FEASIBILITY STUDY

Author

Mana H. Vriesman, Sophie Kuizenga-Wessel, Carlo Di Lorenzo, Alex Menys, Aart J. Nederveen, Brent Adler, Catharina S. de Jonge, Marc A. Benninga, and Jaap Stoker

Subjects
Hepatology, business.industry, Gastroenterology, Medicine, Motility, Functional constipation, business, Nuclear medicine, medicine.disease, Cine mri
Published
2020
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12. 930 – Decline in Unnecessary Surgery for Locally Advanced Rectal Cancer Due to Adequate Multidisciplinary Response Evaluation Following Chemo-Radiotherapy

Author

Huisman, Jelle F., primary, Schoenaker, Ivonne, additional, Brohet, Richard, additional, Reerink, Onne, additional, van der Sluis, Hedwig, additional, Moll, Freek, additional, de Boer, Erwin, additional, de Graaf, Jacques, additional, de Vos tot Nederveen Cappel, Wouter, additional, and van Westreenen, Erik, additional

Published
2019
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14. 930 – Decline in Unnecessary Surgery for Locally Advanced Rectal Cancer Due to Adequate Multidisciplinary Response Evaluation Following Chemo-Radiotherapy

Author

I. J. H. Schoenaker, Richard M. Brohet, Wouter H. de Vos tot Nederveen Cappel, Erik van Westreenen, F.L. Moll, Erwin de Boer, O. Reerink, Hedwig van der Sluis, Jacques de Graaf, and Jelle F. Huisman

Subjects
Chemo-radiotherapy, medicine.medical_specialty, Hepatology, Multidisciplinary approach, Colorectal cancer, business.industry, General surgery, Unnecessary Surgery, Gastroenterology, Locally advanced, medicine, medicine.disease, business
Published
2019
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16. High Lymph Node Yield is Associated with a Decreased Risk for Recurrence after Surgical Resection of T1 Colorectal Cancer

Author

Frank H J Wolfhagen, L.M.G. Moons, Marcel Spanier, Joost M J Geesing, Paul Pullens, Jeroen D van Bergeijk, Marjon Kerkhof, John N. Groen, T. C. Seerden, Yara Backes, Sjoerd G. Elias, Miangela M. Lacle, Koen Kessels, Frank ter Borg, Wouter H. de Vos tot Nederveen Cappel, Niels van Lelyveld, Johan Offerhaus, Soerajja Bhoelan, and Peter D. Siersema

Subjects
Oncology, Surgical resection, medicine.medical_specialty, Hepatology, business.industry, Colorectal cancer, Yield (finance), Gastroenterology, medicine.disease, medicine.anatomical_structure, Internal medicine, medicine, Radiology, business, Lymph node
Published
2017
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18. High Lymph Node Yield is Associated with a Decreased Risk for Recurrence after Surgical Resection of T1 Colorectal Cancer

Author

Backes, Yara, primary, Elias, Sjoerd G., additional, Bhoelan, Soerajja, additional, Groen, John N., additional, van Bergeijk, Jeroen, additional, Seerden, Tom, additional, Pullens, Paul, additional, Spanier, Marcel, additional, Geesing, Joost M., additional, Kessels, Koen, additional, Kerkhof, Marjon, additional, Siersema, Peter D., additional, de Vos tot Nederveen Cappel, Wouter, additional, van Lelyveld, Niels, additional, Wolfhagen, Frank H., additional, ter Borg, Frank, additional, Offerhaus, Johan, additional, Lacle, Miangela M., additional, and Moons, L.M.G., additional

Published
2017
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19. Su1942 Randomized Comparison of Surveillance Intervals in Familial Colorectal Cancer

Author

Hennink, Simone D., primary, van der Meulen - de Jong, Andrea E., additional, Wolterbeek, Ron, additional, Crobach, Stijn, additional, Becx, Marco, additional, Crobach, Wiet, additional, van Haastert, Michiel, additional, Ten Hove, Rogier, additional, Kleibeuker, Jan H., additional, Meijssen, Maarten, additional, Nagengast, Fokko, additional, Rijk, Marno C., additional, Salemans, Jan, additional, Stronkhorst, Arnold, additional, Tuynman, Hans, additional, Vecht, Juda, additional, Verhulst, Marie-Louise, additional, de Vos tot Nederveen Cappel, Wouter H., additional, Walinga, Herman, additional, Weinhardt, Olaf, additional, Westerveld, Dik, additional, Witte, Anne, additional, Wolters, Hugo, additional, Veenendaal, Roeland, additional, Morreau, Hans, additional, and Vasen, Hans F., additional

Published
2015
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21. Tu1977 - High Lymph Node Yield is Associated with a Decreased Risk for Recurrence after Surgical Resection of T1 Colorectal Cancer

Author

Backes, Yara, Elias, Sjoerd G., Bhoelan, Soerajja, Groen, John N., van Bergeijk, Jeroen, Seerden, Tom, Pullens, Paul, Spanier, Marcel, Geesing, Joost M., Kessels, Koen, Kerkhof, Marjon, Siersema, Peter D., de Vos tot Nederveen Cappel, Wouter, van Lelyveld, Niels, Wolfhagen, Frank H., ter Borg, Frank, Offerhaus, Johan, Lacle, Miangela M., and Moons, L.M.G.

Published
2017
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23. Su1942 Randomized Comparison of Surveillance Intervals in Familial Colorectal Cancer

Author

J. M. J. I. Salemans, Wiet F.S.J. Crobach, Michiel van Haastert, Olaf K. Weinhardt, Maarten Meijssen, Andrea E. van der Meulen de Jong, Rogier ten Hove, Wouter H. de Vos tot Nederveen Cappel, Simone D. Hennink, Roeland A. Veenendaal, Juda Vecht, A. M. C. Witte, Marno C.M. Rijk, Ron Wolterbeek, Marco C. Becx, Hans F. A. Vasen, Stijn Crobach, Marie-Louise Verhulst, Hugo J. Wolters, Jan H. Kleibeuker, Herman Walinga, Arnold Stronkhorst, Hans Morreau, Hans Tuynman, Dik B. Westerveld, and Fokko M. Nagengast

Subjects
Oncology, medicine.medical_specialty, Hepatology, Colorectal cancer, business.industry, Internal medicine, Gastroenterology, medicine, medicine.disease, business
Published
2015
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25. 242 Brain Processing of Rectal Sensation in Children With Chronic Functional Constipation

Author

Michiel B. de Ruiter, Liesbeth Reneman, Suzanne M. Mugie, Aart J. Nederveen, Paul J. Groot, Marc A. Benninga, and Maartje M. van den Berg

Subjects
medicine.medical_specialty, Constipation, Hepatology, medicine.diagnostic_test, business.industry, Gastroenterology, Visceral pain, Distension, medicine.disease, Barostat, Dorsolateral prefrontal cortex, medicine.anatomical_structure, Internal medicine, Sensation, medicine, Cardiology, Functional constipation, medicine.symptom, Functional magnetic resonance imaging, business
Abstract

Background and Objective: The pathophysiology underlying pediatric chronic functional constipation (FC) is poorly understood. These children often report loss of sensation of urge to defecate. Functional magnetic resonance imaging (fMRI) studies have been used to unravel brain processing of visceral sensation in adults with functional gastrointestinal disorders. However, brain-imaging data are lacking in both adults and children with constipation. The aim is to investigate the cerebral activity in response to rectal distension in children with FC and in healthy controls (HCs). Methods: 15 patients with FC (8M/7F; mean age 14.3 yrs, range 12-18 yrs) and 15 HCs (6M/9F; mean age 20.1 yrs, range 18-21 yrs) participated. Rectal barostat was performed prior to the fMRI scan. A stepwise pressure-controlled distension protocol was used to determine the pressure threshold for urge sensation. Subjects received 2 sessions of 5 stimulations consisting of repetitions of 30 sec of rectal stimulation with previous defined pressure threshold, followed by 30 sec of rest during acquisition blood oxygenation level-dependent (BOLD) fMRI. Images were acquired on a 3Tesla MRI scanner with an 8-channel SENSE head receive coil. A T2*-weighted echo planar imaging sequence was acquired with: TR/TE=3000/30 ms, slice thickness=3.0 mm, voxel size=1.72 x 1.72 x 3 mm, with 40 axial slices, in ascending mode covering the whole brain. fMRI signal differences were analyzed using SPM8 in Matlab, thresholded at p

Published
2014
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27. 108 Prevalence of Small Bowel Neoplasia in Lynch Syndrome As Assessed by Capsule Endoscopy

Author

Haanstra, Jasmijn F., primary, Al-Toma, Abdul, additional, Dekker, Evelien, additional, Cats, Annemieke, additional, Nagengast, Fokko, additional, van Leerdam, Monique E., additional, de Vos tot Nederveen Cappel, Wouter H., additional, Sanduleanu, Silvia, additional, Veenendaal, Roeland, additional, Vasen, Hans F., additional, Kleibeuker, Jan H., additional, and Koornstra, Jan J., additional

Published
2013
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29. 108 Prevalence of Small Bowel Neoplasia in Lynch Syndrome As Assessed by Capsule Endoscopy

Author

Evelien Dekker, Jasmijn F. Haanstra, Roeland A. Veenendaal, Wouter H. de Vos tot Nederveen Cappel, Silvia Sanduleanu, Jan J. Koornstra, Jan H. Kleibeuker, Abdulbaqi Al-toma, Monique E. van Leerdam, Fokko M. Nagengast, Hans F. A. Vasen, and Annemieke Cats

Subjects
medicine.medical_specialty, Hepatology, business.industry, Capsule endoscopy, law, Internal medicine, Gastroenterology, medicine, business, medicine.disease, Lynch syndrome, law.invention
Published
2013
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31. Quality of Life After Surgery for Colon Cancer in Patients With Lynch Syndrome; Partial Versus (Sub)Total Colectomy

Author

Haanstra, Jasmijn F, primary, de Vos tot Nederveen Cappel, Wouter H., additional, Vanhoutvin, Steven, additional, Cats, Annemieke, additional, Vecht, Juda, additional, Kleibeuker, Jan H., additional, Langers, Alexandra, additional, van de Meeberg, Paul C., additional, Dekker, Evelien, additional, Bergmann, Jerry H., additional, Vasen, Hans F., additional, Nagengast, Fokko, additional, and van Duijvendijk, Peter, additional

Published
2011
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32. Magnetic Resonance Imaging Surveillance Detects Early-Stage Pancreatic Cancer in Carriers of a p16-Leiden Mutation

Author

Vasen, Hans F.A., primary, Wasser, Martin, additional, van Mil, Anneke, additional, Tollenaar, Rob A., additional, Konstantinovski, Marja, additional, Gruis, Nelleke A., additional, Bergman, Wilma, additional, Hes, Frederik J., additional, Hommes, Daniel W., additional, Offerhaus, G. Johan A., additional, Morreau, Hans, additional, Bonsing, Bert A., additional, and de Vos tot Nederveen Cappel, Wouter H., additional

Published
2011
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33. Tu1050 Predicting NAFLD in Severely Obese Children and Adolescents: Noninvasive Prediction Rules and Novel Biomarkers Lack Sufficient Diagnostic Accuracy

Author

Peter L.M. Jansen, Maruschka P. Merkus, Aart J. Nederveen, Anneloes E. Bohte, Bart G. P. Koot, Jaap Stoker, Marc A. Benninga, and Olga H. van der Baan-Slootweg

Subjects
Pediatrics, medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, medicine, Diagnostic accuracy, business
Published
2012
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35. Quality of Life After Surgery for Colon Cancer in Patients With Lynch Syndrome; Partial Versus (Sub)Total Colectomy

Author

Peter van Duijvendijk, Hans F. A. Vasen, Fokko M. Nagengast, Jerry H W Bergmann, Wouter H. de Vos tot Nederveen Cappel, Paul C. van de Meeberg, Steven Vanhoutvin, Jan H. Kleibeuker, Juda Vecht, Alexandra M. J. Langers, Jasmijn F. Haanstra, Annemieke Cats, and Evelien Dekker

Subjects
Total Colectomy, medicine.medical_specialty, Hepatology, Quality of life, business.industry, Colorectal cancer, Gastroenterology, Medicine, In patient, business, medicine.disease, Lynch syndrome, Surgery
Published
2011
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38. M1190 5-Aminosalicylic Acid Induces Colorectal Cancer Cell Death In Vitro and In Vivo

Author

Alexandra M. J. Langers, Pim J. Koelink, Wouter H. de Vos tot Nederveen Cappel, Daniel W. Hommes, Hein W. Verspaget, and Cornelis B.H.W. Lamers

Subjects
Oncology, medicine.medical_specialty, Cell signaling, Hepatology, biology, business.industry, Kinase, Colorectal cancer, Gastroenterology, Cancer, Mouse model of colorectal and intestinal cancer, medicine.disease, Receptor tyrosine kinase, Internal medicine, medicine, biology.protein, Cancer research, Kinome, Signal transduction, business
Abstract

INTRODUCTION: Colorectal cancer (CRC) is one of the leading causes of death by cancer in theWestern world. Unfortunately, successful treatment is dependent still on early diagnosis and surgical resection. Epidemiological studies suggest that Statins have powerful chemopreventive properties with respect to colon cancer, but the mechanism of action of Statins in colon cancer is unknown. Most research has focused on the post-translational prenylation of proteins, but several studies have shown that statins also have additional effects. A limited number of well characterized signal transduction pathways allow cells to react to their environment and are regulated by phosphorylation. By generating a comprehensive description of the phosphoproteome we aimed to investigate the mechanism of action of statins in colon cancer cells in an unbiased fashion. AIMS & METHODS: Aim: To elucidate the molecular mechanism of action of Statins in colorectal cancer. Methods: We used arrays containing 1024 different kinase substrates spanning the entire human kinome. The peptide arrays were incubated with cell lysates plus radioactive ATP, exposed to a phospho-imaging screen and scanned. The density of the spots was measured and analyzed with array software. Western blotting was used to independently validate the results. RESULTS: To analyze the changes in the phosphoproteome we determined the number of significantly phosphorylated substrates for each condition. Statin treatment for 24 hours leads to a substantial downregulation of cell signaling. Non-treated cells displayed phosphorylation of 222 substrates, and treated cells 151 substrates. While most other pathways remained unaffected the activity of multiple Receptor Tyrosine Kinases (RTKs) was significantly decreased with down regulation of their downstream targets. As RTKs play a well known role in cell cycle progression, growth and metabolism control, their inhibition by statins may provide a new insight into the chemopreventive properties of this drug. CONCLUSION: Treatment of colon cancer cells with Statins alters intracellular signaling by downregulation of the activity of multiple Receptor Tyrosine Kinases and its downstream pathways. This insight could help to identify a group of patients with CRC where Statins can be successfully used as chemotherapeutic and chemopreventive drugs.

Published
2010
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39. M1010 Assessment of Non-Alcoholic Fatty Liver Disease in Morbidly Obese Children Using 3.0 TESLA Magnetic Resonance Spectroscopy

Author

Marc A. Benninga, Tammo H. Pels Rijcken, Olga van der Baan, Jaap Stoker, Aart J. Nederveen, Peter L.M. Jansen, Bart G. P. Koot, and Jochem R. van Werven

Subjects
medicine.medical_specialty, Hepatology, business.industry, Fatty liver, Gastroenterology, Non alcoholic, Disease, Nuclear magnetic resonance spectroscopy, Morbidly obese, medicine.disease, Internal medicine, medicine, business
Published
2009
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40. T1615 Treatment of Experimental Steatosis with Omega 3 Fatty Acids Assessed Non-Invasively By 3.0 TESLA 1h-Magnetic Resonance Spectroscopy

Author

Thomas M. van Gulik, Michal Heger, Hendrik A. Marsman, Syert L. Nienhuis, Jaap Stoker, Aart J. Nederveen, Fiebo J.W. ten Kate, and Jochem R. van Werven

Subjects
Nuclear magnetic resonance, Hepatology, Chemistry, Gastroenterology, medicine, Nuclear magnetic resonance spectroscopy, Steatosis, medicine.disease, Omega
Published
2009
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