Search

Your search keyword '"Miura, H."' showing total 10 results
Start Over Author "Miura, H." Journal gastroenterology
10 results on '"Miura, H."'

1. A role of phospholipase A2 in cholesterol gallstone pathogenesis is associated with biliary phospholipid species subselection at a site of hepatic excretion

Author

Hattori, Y., primary, Tazuma, S., additional, Yamashita, G., additional, Sunami, Y., additional, Yasumiba, S., additional, Hyogo, H., additional, Nishioka, T., additional, Miyake, H., additional, Miura, H., additional, Kajihara, T., additional, Ochi, H., additional, and Kajiyama, G., additional

Published
1998
Full Text
View/download PDF

3. Ursodeoxycholate, but not other cytoprotective bile acids, reduces biliary arachidonyl-lecithin secretion, and thereby stabilizes a physical chemical state of bile lipids

Author

Miyake, H., primary, Tazuma, S., additional, Miura, H., additional, Hattori, Y., additional, Kajihara, T., additional, Nishioka, T., additional, Hyogo, H., additional, Sunami, Y., additional, Yasumiba, S., additional, Ochi, H., additional, Yamashita, G., additional, and Kajiyama, G., additional

Published
1998
Full Text
View/download PDF

6. Factors affecting bile lecithin hydrophobicity: Implication of bile cholesterol metastability during organic anion-induced cholestasis

Author

Tazuma, S, primary, Ochi, H, additional, Miura, H, additional, Horikawa, K, additional, Miyake, H, additional, Hirano, N, additional, Teramen, K, additional, Tsuchimoto, D, additional, Hattori, Y, additional, Kajihara, T., additional, Alhara, N, additional, Nishioka, T, additional, Hatsushika, S, additional, Ohya, T, additional, Kajiyama, G, additional, and Itoh, K, additional

Published
1995
Full Text
View/download PDF

7. A novel method for simultaneous quantititation of vesicle aggregation and fusion: Relation to biliary lipid secretion and bile metastability

Author

Ochi, H, primary, Tazuma, S, additional, Ohya, T, additional, Hattori, Y, additional, Horikawa, K, additional, Teramen, K, additional, Hirano, N, additional, Miura, H, additional, Tsuchimoto, D, additional, Miyake, H, additional, Kajihara, T., additional, Nishioka, T, additional, Hatsushika, S, additional, Kajiyama, G, additional, and Itoh, K, additional

Published
1995
Full Text
View/download PDF

10. Tests for serum levels of trefoil factor family proteins can improve gastric cancer screening.

Author

Aikou S, Ohmoto Y, Gunji T, Matsuhashi N, Ohtsu H, Miura H, Kubota K, Yamagata Y, Seto Y, Nakajima A, Goldenring JR, Kaminishi M, and Nomura S

Subjects
Adult, Aged, Case-Control Studies, Helicobacter Infections blood, Helicobacter pylori, Humans, Japan, Male, Middle Aged, Pepsinogen A blood, Sensitivity and Specificity, Trefoil Factor-1, Trefoil Factor-2, Trefoil Factor-3, Tumor Suppressor Proteins blood, Biomarkers, Tumor blood, Early Detection of Cancer methods, Peptides blood, Stomach Neoplasms blood, Stomach Neoplasms diagnosis
Abstract

Background & Aims: Improving methods for early detection of gastric cancer could reduce mortality. Measurements of serum pepsinogen levels have been used for screening in Japan without satisfactory levels of sensitivity or specificity. Trefoil factor family (TFF) proteins (TFF1, TFF2, and TFF3) are small and stable molecules secreted by the mammalian gastrointestinal tract. Foveolar hyperplasia, spasmolytic polypeptide (TFF2)-expressing metaplasia, and intestinal metaplasia are histologic changes observed in patients with atrophic gastritis; they express TFF1, TFF2, and TFF3, respectively. We investigated whether serum levels of TFF can be used as markers for gastric cancer screening., Methods: Serum was collected from 183 patients with gastric cancer and 280 healthy individuals without cancer. Serum levels of anti-Helicobacter pylori immunoglobulin G, pepsinogen I, pepsinogen II, TFF1, TFF2, and TFF3 were measured by enzyme-linked immunosorbent assay and associated with gastric cancer., Results: Using a cutoff of 3.6 ng/mL, the level of TFF3 was significantly increased in serum samples from patients with cancer (odds ratio, 18.1; 95% confidence interval, 11.2-29.2); using this test, patients with cancer were identified with 80.9% sensitivity and 81.0% specificity. The test for TFF3 had a significantly higher odds ratio than that for pepsinogen. A test for the combination of TFF3 and pepsinogen had better results than the test for only pepsinogen., Conclusions: Serum levels of TFF3 are a better marker of gastric cancer than pepsinogen; a test for the combined levels of serum pepsinogen and TFF3 could improve gastric cancer screening., (Copyright © 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.)

Published
2011
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results