1. Symptoms Have Modest Accuracy in Detecting Endoscopic and Histologic Remission in Adults With Eosinophilic Esophagitis
- Author
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Safroneeva, Ekaterina, Straumann, Alex, Coslovsky, Michael, Zwahlen, Marcel, Kuehni, Claudia E, Panczak, Radoslaw, Haas, Nadine A, Alexander, Jeffrey A, Dellon, Evan S, Gonsalves, Nirmala, Hirano, Ikuo, Leung, John, Bussmann, Christian, Collins, Margaret H, Newbury, Robert O, De Petris, Giovanni, Smyrk, Thomas C, Woosley, John T, Yan, Pu, Yang, Guang-Yu, Romero, Yvonne, Katzka, David A, Furuta, Glenn T, Gupta, Sandeep K, Aceves, Seema S, Chehade, Mirna, Spergel, Jonathan M, Schoepfer, Alain M, Group, International Eosinophilic Esophagitis Activity Index Study, Achem, Sami R, Arora, Amindra S, Alpan, Oral, Armstrong, David, Attwood, Stephen E, Butterfield, Joseph H, Crowell, Michael D, DeVault, Kenneth R, Drouin, Eric, Enav, Benjamin, Enders, Felicity T, Fleischer, David E, Foxx-Orenstein, Amy, Francis, Dawn L, Guyatt, Gordon H, Harris, Lucinda A, Kagalwalla, Amir F, Kita, Hirohito, Krishna, Murli, Lee, James J, Lewis, John C, Lim, Kaiser, Locke, G Richard, Murray, Joseph A, Nguyen, Cuong C, Orbelo, Diana M, Pasha, Shabana F, Ramirez, Francisco C, Sheikh, Javed, Umar, Sarah B, Weiler, Catherine R, Wo, John M, Wu, Tsung-Teh, and Yost, Kathleen J
- Subjects
Biomedical and Clinical Sciences ,Clinical Sciences ,Digestive Diseases ,Cancer ,Clinical Research ,4.2 Evaluation of markers and technologies ,Detection ,screening and diagnosis ,Adolescent ,Adult ,Aged ,Aged ,80 and over ,Area Under Curve ,Biopsy ,Eosinophilic Esophagitis ,Eosinophils ,Esophagoscopy ,Female ,Humans ,Leukocyte Count ,Male ,Middle Aged ,Predictive Value of Tests ,Prospective Studies ,ROC Curve ,Remission Induction ,Reproducibility of Results ,Severity of Illness Index ,Surveys and Questionnaires ,Switzerland ,Treatment Outcome ,United States ,Young Adult ,EEsAI ,Remission ,Endoscopic Grading ,Disease Monitoring ,International Eosinophilic Esophagitis Activity Index Study Group ,Neurosciences ,Paediatrics and Reproductive Medicine ,Gastroenterology & Hepatology ,Clinical sciences ,Nutrition and dietetics - Abstract
Background & aimsIt is not clear whether symptoms alone can be used to estimate the biologic activity of eosinophilic esophagitis (EoE). We aimed to evaluate whether symptoms can be used to identify patients with endoscopic and histologic features of remission.MethodsBetween April 2011 and June 2014, we performed a prospective, observational study and recruited 269 consecutive adults with EoE (67% male; median age, 39 years old) in Switzerland and the United States. Patients first completed the validated symptom-based EoE activity index patient-reported outcome instrument and then underwent esophagogastroduodenoscopy with esophageal biopsy collection. Endoscopic and histologic findings were evaluated with a validated grading system and standardized instrument, respectively. Clinical remission was defined as symptom score
- Published
- 2016