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10. American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis

Author

Megan A. Adams, Sharon Dudley-Brown, Joel H. Rubenstein, Walter Smalley, David S. Weinberg, Lawrence R. Kosinski, Steven L. Flamm, Yvonne Romero, Neil Stollman, Walter E. Smalley, Yu-Xiao Yang, Spencer D. Dorn, Shahnaz Sultan, Joseph K. Lim, Claudia B. Gruss, Ikuo Hirano, and Ziad F. Gellad

Subjects
Dietary Fiber, medicine.medical_specialty, Consensus, Treatment outcome, Computed tomography, Risk Assessment, Gastroenterology, Article, Gastrointestinal Agents, Predictive Value of Tests, Risk Factors, Internal medicine, medicine, Humans, Mesalamine, Colectomy, Diverticulitis, Gastrointestinal agent, Hepatology, medicine.diagnostic_test, Acute diverticulitis, business.industry, Patient Selection, General surgery, Anti-Inflammatory Agents, Non-Steroidal, Colonoscopy, Guideline, medicine.disease, Anti-Bacterial Agents, Diet, Treatment Outcome, Tomography x ray computed, Elective Surgical Procedures, Acute Disease, Dietary fiber, Tomography, X-Ray Computed, business
Published
2015

11. Su1793 PROXIMAL VERSUS DISTAL COLON ADR: A NEW COLONOSCOPY QUALITY METRIC

Author

David A. Lieberman, Leanne Metcalfe, Lan Vu, Sachin Singh, and Lawrence R. Kosinski

Subjects
medicine.medical_specialty, Hepatology, medicine.diagnostic_test, business.industry, media_common.quotation_subject, Gastroenterology, Colonoscopy, Medicine, Quality (business), Metric (unit), Radiology, Distal colon, business, media_common
Published
2020

16. American Gastroenterological Association Institute Guideline on the Role of Upper Gastrointestinal Biopsy to Evaluate Dyspepsia in the Adult Patient in the Absence of Visible Mucosal Lesions

Author

Yu-Xiao Yang, Joel Brill, Prashant Krishnan, Grigorios Leontiadis, Megan A. Adams, Spencer D. Dorn, Sharon L. Dudley-Brown, Steven L. Flamm, Ziad F. Gellad, Claudia B. Gruss, Lawrence R. Kosinski, Joseph K. Lim, Yvonne Romero, Joel H. Rubenstein, Walter E. Smalley, Shahnaz Sultan, and David S. Weinberg

Subjects
Adult, Mucous Membrane, Hepatology, Biopsy, Patient Selection, Age Factors, Gastroenterology, Reproducibility of Results, Prognosis, Endoscopy, Gastrointestinal, Immunocompromised Host, Upper Gastrointestinal Tract, Young Adult, Predictive Value of Tests, Risk Factors, Humans, Dyspepsia
Published
2015

17. Su1786 – Reduction in Costs of Care in Patients with Crohn’s Disease in a Community Practice-Based Medical Home Over Two Years: A Propensity Score Matched Cohort Analysis

Author

Joel V. Brill, William J. Sandborn, Derek Blankenship, Siddharth Singh, Leanne Metcalfe, and Lawrence R. Kosinski

Subjects
Medical home, medicine.medical_specialty, Crohn's disease, Hepatology, business.industry, medicine.medical_treatment, Gastroenterology, medicine.disease, Matched cohort, Internal medicine, Propensity score matching, medicine, Community practice, In patient, business, Reduction (orthopedic surgery)
Published
2019

18. Mo1559 – General Population Prevalence and Clinical Characteristics of Adults Diagnosed with Cyclic Vomiting Syndrome: Analysis of Greater Than 37 Million People from the Accrual to Clinical Trials Network

Author

Emily Kosinski and David J. Levinthal

Subjects
education.field_of_study, Pediatrics, medicine.medical_specialty, Hepatology, business.industry, Cyclic vomiting syndrome, Accrual, Population, Gastroenterology, medicine.disease, Clinical trial, Medicine, business, education
Published
2019

19. Hepatitis C Screening: Summary of Recommendations From the Clinical Decision Tool

Author

Arnold G. Levy, Stuart C. Gordon, Ronald Nahass, Lawrence R. Kosinski, John I. Allen, Mark D. Boldt, Joel V. Brill, Arthur Y. Kim, and Gary L. Davis

Subjects
medicine.medical_specialty, Hepatology, Diagnostic Tests, Routine, Task force, business.industry, Gastroenterology, Hepatitis C, United States, Decision Support Techniques, Hepatitis C screening, Family medicine, medicine, Humans, Mass Screening, University medical, General hospital, Clinical decision, business, Societies, Medical
Abstract

The Hepatitis C Task Force includes: Mark D. Boldt, RN, CNP, Minnesota Gastroenterology; Joel V. Brill, MD, AGAF, Predictive Health; Gary L. Davis, MD, Baylor University Medical Center Dallas(retired); Stuart C. Gordon, MD, AGAF, Henry Ford Health System; Arthur Y. Kim, MD, FIDSA, Massachusetts General Hospital; Lawrence R. Kosinski, MD, MBA, AGAF, Illinois Gastroenterology Group; Arnold G. Levy, MD, Capital Digestive Care; Ronald G. Nahass, MD, MHCM, FIDSA, ID Care; and John I. Allen, MD, MBA, AGAF (Chair), Yale School of Medicine.

Published
2013

21. Tu1013 - Deployment of a Clinical Decision Support Tool more Accurately Identifies Patients with Irritable Bowel Syndrome with Diarrhea and their Symptoms in Real-World Clinical Practice

Author

Lawrence R. Kosinski, Jonathan Rosenberg, and Jessica L. Abel

Subjects
medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, medicine.disease, Clinical decision support system, Clinical Practice, Diarrhea, Software deployment, medicine, medicine.symptom, Intensive care medicine, business, Irritable bowel syndrome
Published
2018

22. American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Lynch Syndrome

Author

Megan A. Adams, David S. Weinberg, Yvonne Romero, Sharon Dudley-Brown, Lawrence R. Kosinski, Steven L. Flamm, Joel H. Rubenstein, Walter E. Smalley, Claudia B. Gruss, Joel J. Heidelbaugh, Ziad F. Gellad, Joseph K. Lim, Robert Enns, Spencer D. Dorn, Alan N. Barkun, Yu-Xiao Yang, and Shahnaz Sultan

Subjects
medicine.medical_specialty, education, Health centre, Decision Support Techniques, Predictive Value of Tests, Risk Factors, medicine, Humans, Genetic Predisposition to Disease, Veterans Affairs, health care economics and organizations, Hepatology, business.industry, Medical school, Gastroenterology, Guideline, medicine.disease, Colorectal Neoplasms, Hereditary Nonpolyposis, humanities, Lynch syndrome, Surgery, Phenotype, Treatment Outcome, Family medicine, Management research, business
Abstract

Veterans Affairs Center for Clinical Management Research; Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, Michigan; Division of Gastroenterology, St Paul’s Hospital, University of British Columbia, Vancouver, British Columbia, Canada; Departments of Family Medicine and Urology, University of Michigan Medical School, Ann Arbor, Michigan; and Division of Gastroenterology, McGill University, McGill University Health Centre, Montreal, Quebec, Canada

Published
2015

23. Ulcerative Colitis Care Pathway

Author

Ellen Scherl, Ronald M. Schwartz, Lawrence R. Kosinski, Miguel Regueiro, Russell D. Cohen, and Themistocles Dassopoulos

Subjects
Adult, Male, medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, MEDLINE, Middle Aged, medicine.disease, Inflammatory Bowel Diseases, Ulcerative colitis, Crohn Disease, Internal medicine, Care pathway, Medicine, Humans, Colitis, Ulcerative, Female, Colitis, business, Delivery of Health Care
Published
2015

24. American gastroenterological association institute guideline on the diagnosis and management of asymptomatic neoplastic pancreatic cysts

Author

David S. Weinberg, Sharon Dudley-Brown, Yvonne Romero, Spencer D. Dorn, Paul Moayyedi, Joel H. Rubenstein, Ziad F. Gellad, Barry Ziring, Lawrence R. Kosinski, Joseph K. Lim, Steven L. Flamm, Megan A. Adams, Santhi Swaroop Vege, Claudia B. Gruss, Rajeev Jain, Walter E. Smalley, Yu-Xiao Yang, and Shahnaz Sultan

Subjects
medicine.medical_specialty, MEDLINE, Adenocarcinoma, Asymptomatic, Risk Assessment, Continuing medical education, medicine, Humans, Societies, Medical, Asymptomatic Diseases, Incidental Findings, Hepatology, medicine.diagnostic_test, Intraductal papillary mucinous neoplasm, business.industry, General surgery, Gastroenterology, Disease Management, Guideline, medicine.disease, Pancreatic Neoplasms, Fine-needle aspiration, Radiology, Pancreatic cysts, medicine.symptom, Pancreatic Cyst, business, Carcinoma, Pancreatic Ductal
Abstract

This article has an accompanying continuing medical education activity on page e12. Learning Objective: At the conclusion of this exercise, the learner will understand the approach to counseling patients regarding the optimal method and frequency of radiologic imaging, indications for invasive tests like endoscopic ultrasonography (EUS) and surgery, select patients for follow-up after surgery, decide the duration of such follow-up, and decide when to stop surveillance for those with and without surgery.

Published
2015

25. A bundled payment framework for colonoscopy performed for colorectal cancer screening or surveillance

Author

Laura E. Clote, Rajeev Jain, John I. Allen, Joel V. Brill, Worthe Holt, Peter S. Margolis, Scott R. Ketover, Lawrence S. Kim, and Lawrence R. Kosinski

Subjects
medicine.medical_specialty, Colorectal cancer, Colonoscopy, medicine, Humans, Fee-for-service, Early Detection of Cancer, Gynecology, Hepatology, medicine.diagnostic_test, business.industry, General surgery, Incidence, Patient Protection and Affordable Care Act, Bundled payments, Gastroenterology, Fee-for-Service Plans, medicine.disease, United States, Models, Economic, Colorectal cancer screening, Epidemiological Monitoring, business, Colorectal Neoplasms, Patient Care Bundles
Published
2014

28. American Gastroenterological Association Institute Guideline on the Management of Acute Diverticulitis

Author

Stollman, Neil, primary, Smalley, Walter, additional, Hirano, Ikuo, additional, Adams, Megan A., additional, Dorn, Spencer D., additional, Dudley-Brown, Sharon L., additional, Flamm, Steven L., additional, Gellad, Ziad F., additional, Gruss, Claudia B., additional, Kosinski, Lawrence R., additional, Lim, Joseph K., additional, Romero, Yvonne, additional, Rubenstein, Joel H., additional, Smalley, Walter E., additional, Sultan, Shahnaz, additional, Weinberg, David S., additional, and Yang, Yu-Xiao, additional

Published
2015
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29. 824 Project Sonar: Reduction in Cost of Care in an Attributed Cohort of Patients With Crohn's Disease

Author

Lawrence R. Kosinski, Michael Sørensen, Pamela Landsman, Robin Turpin, Charles Baum, and Joel V. Brill

Subjects
Crohn's disease, medicine.medical_specialty, Pediatrics, Hepatology, business.industry, medicine.medical_treatment, Gastroenterology, medicine.disease, Sonar, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Cohort, medicine, Physical therapy, 030211 gastroenterology & hepatology, business, Cost of care, Reduction (orthopedic surgery)
Published
2016

30. American Gastroenterological Association Institute Guideline on the Role of Upper Gastrointestinal Biopsy to Evaluate Dyspepsia in the Adult Patient in the Absence of Visible Mucosal Lesions

Author

Yang, Yu-Xiao, primary, Brill, Joel, additional, Krishnan, Prashant, additional, Leontiadis, Grigorios, additional, Adams, Megan A., additional, Dorn, Spencer D., additional, Dudley-Brown, Sharon L., additional, Flamm, Steven L., additional, Gellad, Ziad F., additional, Gruss, Claudia B., additional, Kosinski, Lawrence R., additional, Lim, Joseph K., additional, Romero, Yvonne, additional, Rubenstein, Joel H., additional, Smalley, Walter E., additional, Sultan, Shahnaz, additional, Weinberg, David S., additional, and Yang, Yu-Xiao, additional

Published
2015
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31. American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Lynch Syndrome

Author

Rubenstein, Joel H., primary, Enns, Robert, additional, Heidelbaugh, Joel, additional, Barkun, Alan, additional, Adams, Megan A., additional, Dorn, Spencer D., additional, Dudley-Brown, Sharon L., additional, Flamm, Steven L., additional, Gellad, Ziad F., additional, Gruss, Claudia B., additional, Kosinski, Lawrence R., additional, Lim, Joseph K., additional, Romero, Yvonne, additional, Rubenstein, Joel H., additional, Smalley, Walter E., additional, Sultan, Shahnaz, additional, Weinberg, David S., additional, and Yang, Yu-Xiao, additional

Published
2015
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32. Ulcerative Colitis Care Pathway

Author

Dassopoulos, Themistocles, primary, Cohen, Russell D., additional, Scherl, Ellen J., additional, Schwartz, Ronald M., additional, Kosinski, Lawrence, additional, and Regueiro, Miguel D., additional

Published
2015
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33. American Gastroenterological Association Institute Guideline on the Diagnosis and Management of Asymptomatic Neoplastic Pancreatic Cysts

Author

Vege, Santhi Swaroop, primary, Ziring, Barry, additional, Jain, Rajeev, additional, Moayyedi, Paul, additional, Adams, Megan A., additional, Dorn, Spencer D., additional, Dudley-Brown, Sharon L., additional, Flamm, Steven L., additional, Gellad, Ziad F., additional, Gruss, Claudia B., additional, Kosinski, Lawrence R., additional, Lim, Joseph K., additional, Romero, Yvonne, additional, Rubenstein, Joel H., additional, Smalley, Walter E., additional, Sultan, Shahnaz, additional, Weinberg, David S., additional, and Yang, Yu-Xiao, additional

Published
2015
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34. Indian hedgehog regulates intestinal stem cell fate through epithelial-mesenchymal interactions during development

Author

Chuanrui Xu, Cynthia Kosinski, Siu Tsan Yuen, Coral Ho, Xin Chen, Hans Clevers, Annie Sy Chan, Daniel E. Stange, Randy C. Mifflin, Suet Yi Leung, Don W. Powell, and Hubrecht Institute for Developmental Biology and Stem Cell Research

Subjects
Cellular differentiation, Cell Communication, Basement Membrane, Mesoderm, Mice, Intestinal mucosa, Intestinal Mucosa - metabolism - pathology, Intestinal Mucosa, In Situ Hybridization, beta Catenin, Mice, Knockout, Extracellular Matrix Proteins, MMP, Stem Cells, Microfilament Proteins, Gastroenterology, Wnt signaling pathway, Cell Differentiation, Colitis, Immunohistochemistry, Hedgehog signaling pathway, Cell biology, Phenotype, Hedgehog interacting protein, Signal Transduction, Indian hedgehog, Genotype, Colon, Biology, digestive system, Epithelial Cells - metabolism - pathology, Article, Paracrine Communication, Colon - metabolism - pathology, BMP, Animals, Cell Lineage, Hedgehog Proteins, Cell Proliferation, ECM, Hepatology, Integrases, Gene Expression Profiling, Mesenchymal stem cell, Epithelial Cells, Hedgehog Proteins - deficiency - genetics - metabolism, biology.organism_classification, Wnt Proteins, Gene Expression Regulation, Immunology, Hedgehog Signaling, Enterocyte differentiation
Abstract

Background & Aims Intestinal stem cells (ISCs) are regulated by the mesenchymal environment via physical interaction and diffusible factors. We examined the role of Indian hedgehog (Ihh) in mesenchymal organization and the mechanisms by which perturbations in epithelial-mesenchymal interactions affect ISC fate. Methods We generated mice with intestinal epithelial-specific disruption of Ihh. Gross and microscopic anatomical changes were determined using histologic, immunohistochemical, and in situ hybridization analyses. Molecular mechanisms were elucidated by expression profiling and in vitro analyses. Results Deletion of intestinal epithelial Ihh disrupted the intestinal mesenchymal architecture, demonstrated by loss of the muscularis mucosae, deterioration of the extracellular matrix, and reductions in numbers of crypt myofibroblasts. Concurrently, the epithelial compartment had increased Wnt signaling, disturbed crypt polarity and architecture, defective enterocyte differentiation, and increased and ectopic proliferation that was accompanied by increased numbers of ISCs. Mechanistic studies revealed that Hh inhibition deregulates bone morphogenetic protein signaling, increases matrix metalloproteinase levels, and disrupts extracellular matrix proteins, fostering a proliferative environment for ISCs and progenitor cells. Conclusions Ihh regulates ISC self-renewal and differentiation. Intestinal epithelial Ihh signals to the mesenchymal compartment to regulate formation and proliferation of mesenchymal cells, which in turn affect epithelial proliferation and differentiation. These findings provide a basis for analyses of the role of the muscularis mucosae in ISC regulation. © 2010 by the AGA Institute., postprint

Published
2009

44. T1339 Expression of 5-HT3 Receptors is Upregulated to Restore Delayed Colonic Transit Following Parasympathetic Denervation of the Rat Colon

Author

Jun Zheng, Weidong Tong, Aaron M. Zietlow, Timothy J. Ridolfi, Lauren Kosinski, Yoichi Kamiyama, Toku Takahashi, and Kirk A. Ludwig

Subjects
medicine.medical_specialty, Endocrinology, Hepatology, Downregulation and upregulation, business.industry, Internal medicine, Gastroenterology, medicine, Parasympathetic Denervation, Receptor, business
Published
2010

48. Hepatitis in an Adult Caused by Herpes Simplex Virus Type I

Author

Katharine Kosinski, Larry Eron, and Martin S. Hirsch

Subjects
Hepatitis, Disseminated intravascular coagulation, medicine.medical_specialty, Pathology, Necrosis, Hepatology, medicine.diagnostic_test, viruses, Gastroenterology, Autopsy, Biology, medicine.disease, medicine.disease_cause, Herpes simplex virus, medicine.anatomical_structure, Immunology, medicine, Histopathology, Esophagus, medicine.symptom, Liver function tests
Abstract

Disseminated infection caused by Herpes simplex virus (HSV) type I is described in a previously healthy adult. The clinical course was characterized by progressive hepatic failure, fever, hypotension, atypical lymphocytosis, and disseminated intravascular coagulation. No skin lesions were present and the causal agent was not suspected premortem; however, HSV-I was isolated from autopsy liver, and characteristic histopathological lesions of herpes infection were observed in liver and esophagus.

Published
1976

49. Hepatitis in an adult caused by Herpes simplex virus type I

Author

L, Eron, K, Kosinski, and M S, Hirsch

Subjects
Male, Necrosis, Esophagus, Liver Function Tests, Humans, Simplexvirus, Herpes Simplex, Thrombosis, Hepatitis A, Esophageal Diseases, Ulcer, Aged, Inclusion Bodies, Viral
Abstract

Disseminated infection caused by Herpes simplex virus (HSV) type I is described in a previously healthy adult. The clinical course was characterized by progressive hepatic failure, fever, hypotension, atypical lymphocytosis, and disseminated intravascular coagulation. No skin lesions were present and the causal agent was not suspended premortem; however, HSV-I was isolated from autopsy liver, and characteristic histopathological lesions of herpes infection were observed in liver and esophagus.

Published
1976

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