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18 results on '"Kench A"'

1. Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence

Author

Allison, Sarah, Biankin, Andrew V., Beraldi, Dario, Cameron, Euan, Chang, David K., Cooke, Susanna L., Cunningham, Richard, Dreyer, Stephan, Grimwood, Paul, Kelly, Shane, Marshall, John, McDade, Brian, Musgrove, Elizabeth A., Ramsay, Donna, Upstill-Goddard, Rosie, Evers, Lisa, Rebus, Selma, Rahib, Lola, Serrels, Bryan, Jamieson, Nigel B., McKay, Colin J., Westwood, Paul, Williams, Nicola, Duthie, Fraser, Shen, William, Pea, Antonio, Johns, Amber L., Gill, Anthony J., Chantrill, Lorraine A., Timpson, Paul, Chou, Angela, Pajic, Marina, Dwarte, Tanya, Herrmann, David, Vennin, Claire, Cox, Thomas R., Pereira, Brooke, Ritchiee, Shona, Reed, Daniel A., Chambers, Cecilia R., Metcalf, Xanthe, Nobis, Max, Jeong, Gloria, Kenyon, Lara, Lyons, Ruth J., Waddell, Nicola, Pearson, John V., Patch, Ann-Marie, Nones, Katia, Newell, Felicity, Mukhopadhyay, Pamela, Addala, Venkateswar, Kazakoff, Stephen, Holmes, Oliver, Leonard, Conrad, Wood, Scott, Grimmond, Sean M., Hofmann, Oliver, Samra, Jaswinder S., Pavlakis, Nick, Arena, Jennifer, High, Hilda A., Asghari, Ray, Merrett, Neil D., Das, Amitabha, Cosman, Peter H., Ismail, Kasim, Stoita, Alina, Williams, David, Spigellman, Allan, McLeod, Duncan, Kirk, Judy, Kench, James G., Grimison, Peter, Sandroussi, Charbel, Goodwin, Annabel, Mead, R. Scott, Tucker, Katherine, Andrews, Lesley, Texler, Michael, Forrest, Cindy, Ballal, Mo, Fletcher, David, Beilin, Maria, Feeney, Kynan, Epari, Krishna, Mukhedkar, Sanjay, Zeps, Nikolajs, Nguyen, Nan Q., Ruszkiewicz, Andrew R., Worthley, Chris, Chen, John, Brooke-Smith, Mark E., Papangelis, Virginia, Clouston, Andrew D., Barbour, Andrew P., O’Rourke, Thomas J., Fawcett, Jonathan W., Slater, Kellee, Hatzifotis, Michael, Hodgkinson, Peter, Nikfarjam, Mehrdad, Eshleman, James R., Hruban, Ralph H., Wolfgang, Christopher L., Scarpa, Aldo, Lawlor, Rita T., Corbo, Vincenzo, Bassi, Claudio, Dreyer, Stephan B., and Legrini, Assya

Published
2022
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2. Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Author

Allison, Sarah, Bailey, Peter J., Bailey, Ulla-Maja, Biankin, Andrew V., Beraldi, Dario, Brunton, Holly, Caligiuri, Giuseppina, Cameron, Euan, Chang, David K., Cooke, Susanna L., Cunningham, Richard, Dreyer, Stephan, Grimwood, Paul, Kelly, Shane, Lampraki, Eirini-Maria, Marshall, John, Martin, Sancha, McDade, Brian, McElroy, Daniel, Musgrove, Elizabeth A., Nourse, Craig, Paulus-Hock, Viola, Ramsay, Donna, Upstill-Goddard, Rosie, Wright, Derek, Jones, Marc D., Evers, Lisa, Rebus, Selma, Rahib, Lola, Serrels, Bryan, Hair, Jane, Jamieson, Nigel B., McKay, Colin J., Westwood, Paul, Williams, Nicola, Duthie, Fraser, Johns, Amber L., Mawson, Amanda, Scarlett, Christopher J., Brancato, Mary-Anne L., Rowe, Sarah J., Simpson, Skye H., Martyn-Smith, Mona, Thomas, Michelle T., Chantrill, Lorraine A., Chin, Venessa T., Chou, Angela, Cowley, Mark J., Humphris, Jeremy L., Mead, R. Scott, Nagrial, Adnan M., Pajic, Marina, Pettit, Jessica, Pinese, Mark, Rooman, Ilse, Wu, Jianmin, Tao, Jiang, DiPietro, Renee, Watson, Clare, Steinmann, Angela, Lee, Hong Ching, Wong, Rachel, Pinho, Andreia V., Giry-Laterriere, Marc, Daly, Roger J., Sutherland, Robert L., Grimmond, Sean M., Waddell, Nicola, Kassahn, Karin S., Miller, David K., Wilson, Peter J., Patch, Ann-Marie, Song, Sarah, Harliwong, Ivon, Idrisoglu, Senel, Nourbakhsh, Ehsan, Manning, Suzanne, Wani, Shivangi, Gongora, Milena, Anderson, Matthew, Holmes, Oliver, Leonard, Conrad, Taylor, Darrin, Wood, Scott, Xu, Christina, Nones, Katia, Fink, J. Lynn, Christ, Angelika, Bruxner, Tim, Cloonan, Nicole, Newell, Felicity, Pearson, John V., Bailey, Peter, Quinn, Michael, Nagaraj, Shivashankar, Kazakoff, Stephen, Waddell, Nick, Krisnan, Keerthana, Quek, Kelly, Wood, David, Samra, Jaswinder S., Gill, Anthony J., Pavlakis, Nick, Guminski, Alex, Toon, Christopher, Asghari, Ray, Merrett, Neil D., Pavey, Darren, Das, Amitabha, Cosman, Peter H., Ismail, Kasim, O’Connnor, Chelsie, Lam, Vincent W., McLeod, Duncan, Pleass, Henry C., Richardson, Arthur, James, Virginia, Kench, James G., Cooper, Caroline L., Joseph, David, Sandroussi, Charbel, Crawford, Michael, Gallagher, James, Texler, Michael, Forest, Cindy, Laycock, Andrew, Epari, Krishna P., Ballal, Mo, Fletcher, David R., Mukhedkar, Sanjay, Spry, Nigel A., DeBoer, Bastiaan, Chai, Ming, Zeps, Nikolajs, Beilin, Maria, Feeney, Kynan, Nguyen, Nan Q., Ruszkiewicz, Andrew R., Worthley, Chris, Tan, Chuan P., Debrencini, Tamara, Chen, John, Brooke-Smith, Mark E., Papangelis, Virginia, Tang, Henry, Barbour, Andrew P., Clouston, Andrew D., Martin, Patrick, O’Rourke, Thomas J., Chiang, Amy, Fawcett, Jonathan W., Slater, Kellee, Yeung, Shinn, Hatzifotis, Michael, Hodgkinson, Peter, Christophi, Christopher, Nikfarjam, Mehrdad, Mountain, Angela, Biobank, Victorian Cancer, Eshleman, James R., Hruban, Ralph H., Maitra, Anirban, Iacobuzio-Donahue, Christine A., Schulick, Richard D., Wolfgang, Christopher L., Morgan, Richard A., Hodgin, Mary, Scarpa, Aldo, Lawlor, Rita T., Beghelli, Stefania, Corbo, Vincenzo, Scardoni, Maria, Bassi, Claudio, Tempero, Margaret A., Graham, Janet S., Dreyer, Stephan B., Paris, Clara, Dray, Eloise, Plenker, Dennis, Galluzzo, Zachary, Tesson, Mathias, Jones, Marc, Moran-Jones, Kim, Wright, Derek W., Oien, Karin, McGregor, Grant A., Gulati, Aditi, Brough, Rachel, Bajrami, Ilirjana, Pettitt, Stephan, Dziubinski, Michele L., Candido, Juliana, Balkwill, Frances, Barry, Simon T., Grützmann, Robert, Johns, Amber, Froeling, Fieke E.M., Beer, Phillip, Petersen, Gloria M., Ashworth, Alan, Frame, Margaret C., Crawford, Howard C., Simeone, Diane M., Lord, Chris, Mukhopadhyay, Debabrata, Pilarsky, Christian, Tuveson, David A., Morton, Jennifer P., and Sansom, Owen J.

Published
2021
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3. Hypermutation In Pancreatic Cancer

Author

Humphris, Jeremy L., Patch, Ann-Marie, Nones, Katia, Bailey, Peter J., Johns, Amber L., McKay, Skye, Chang, David K., Miller, David K., Pajic, Marina, Kassahn, Karin S., Quinn, Michael C.J., Bruxner, Timothy J.C., Christ, Angelika N., Harliwong, Ivon, Idrisoglu, Senel, Manning, Suzanne, Nourse, Craig, Nourbakhsh, Ehsan, Stone, Andrew, Wilson, Peter J., Anderson, Matthew, Fink, J. Lynn, Holmes, Oliver, Kazakoff, Stephen, Leonard, Conrad, Newell, Felicity, Waddell, Nick, Wood, Scott, Mead, Ronald S., Xu, Qinying, Wu, Jianmin, Pinese, Mark, Cowley, Mark J., Jones, Marc D., Nagrial, Adnan M., Chin, Venessa T., Chantrill, Lorraine A., Mawson, Amanda, Chou, Angela, Scarlett, Christopher J., Pinho, Andreia V., Rooman, Ilse, Giry-Laterriere, Marc, Samra, Jaswinder S., Kench, James G., Merrett, Neil D., Toon, Christopher W., Epari, Krishna, Nguyen, Nam Q., Barbour, Andrew, Zeps, Nikolajs, Jamieson, Nigel B., McKay, Colin J., Carter, C. Ross, Dickson, Euan J., Graham, Janet S., Duthie, Fraser, Oien, Karin, Hair, Jane, Morton, Jennifer P., Sansom, Owen J., Grützmann, Robert, Hruban, Ralph H., Maitra, Anirban, Iacobuzio-Donahue, Christine A., Schulick, Richard D., Wolfgang, Christopher L., Morgan, Richard A., Lawlor, Rita T., Rusev, Borislav, Corbo, Vincenzo, Salvia, Roberto, Cataldo, Ivana, Tortora, Giampaolo, Tempero, Margaret A., Hofmann, Oliver, Eshleman, James R., Pilarsky, Christian, Scarpa, Aldo, Musgrove, Elizabeth A., Gill, Anthony J., Pearson, John V., Grimmond, Sean M., Waddell, Nicola, and Biankin, Andrew V.

Published
2017
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4. Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence

Author

Dreyer, Stephan B., primary, Upstill-Goddard, Rosie, additional, Legrini, Assya, additional, Biankin, Andrew V., additional, Jamieson, Nigel B., additional, Chang, David K., additional, Allison, Sarah, additional, Beraldi, Dario, additional, Cameron, Euan, additional, Cooke, Susanna L., additional, Cunningham, Richard, additional, Dreyer, Stephan, additional, Grimwood, Paul, additional, Kelly, Shane, additional, Marshall, John, additional, McDade, Brian, additional, Musgrove, Elizabeth A., additional, Ramsay, Donna, additional, Evers, Lisa, additional, Rebus, Selma, additional, Rahib, Lola, additional, Serrels, Bryan, additional, McKay, Colin J., additional, Westwood, Paul, additional, Williams, Nicola, additional, Duthie, Fraser, additional, Shen, William, additional, Pea, Antonio, additional, Johns, Amber L., additional, Gill, Anthony J., additional, Chantrill, Lorraine A., additional, Timpson, Paul, additional, Chou, Angela, additional, Pajic, Marina, additional, Dwarte, Tanya, additional, Herrmann, David, additional, Vennin, Claire, additional, Cox, Thomas R., additional, Pereira, Brooke, additional, Ritchiee, Shona, additional, Reed, Daniel A., additional, Chambers, Cecilia R., additional, Metcalf, Xanthe, additional, Nobis, Max, additional, Jeong, Gloria, additional, Kenyon, Lara, additional, Lyons, Ruth J., additional, Waddell, Nicola, additional, Pearson, John V., additional, Patch, Ann-Marie, additional, Nones, Katia, additional, Newell, Felicity, additional, Mukhopadhyay, Pamela, additional, Addala, Venkateswar, additional, Kazakoff, Stephen, additional, Holmes, Oliver, additional, Leonard, Conrad, additional, Wood, Scott, additional, Grimmond, Sean M., additional, Hofmann, Oliver, additional, Samra, Jaswinder S., additional, Pavlakis, Nick, additional, Arena, Jennifer, additional, High, Hilda A., additional, Asghari, Ray, additional, Merrett, Neil D., additional, Das, Amitabha, additional, Cosman, Peter H., additional, Ismail, Kasim, additional, Stoita, Alina, additional, Williams, David, additional, Spigellman, Allan, additional, McLeod, Duncan, additional, Kirk, Judy, additional, Kench, James G., additional, Grimison, Peter, additional, Sandroussi, Charbel, additional, Goodwin, Annabel, additional, Mead, R. Scott, additional, Tucker, Katherine, additional, Andrews, Lesley, additional, Texler, Michael, additional, Forrest, Cindy, additional, Ballal, Mo, additional, Fletcher, David, additional, Beilin, Maria, additional, Feeney, Kynan, additional, Epari, Krishna, additional, Mukhedkar, Sanjay, additional, Zeps, Nikolajs, additional, Nguyen, Nan Q., additional, Ruszkiewicz, Andrew R., additional, Worthley, Chris, additional, Chen, John, additional, Brooke-Smith, Mark E., additional, Papangelis, Virginia, additional, Clouston, Andrew D., additional, Barbour, Andrew P., additional, O’Rourke, Thomas J., additional, Fawcett, Jonathan W., additional, Slater, Kellee, additional, Hatzifotis, Michael, additional, Hodgkinson, Peter, additional, Nikfarjam, Mehrdad, additional, Eshleman, James R., additional, Hruban, Ralph H., additional, Wolfgang, Christopher L., additional, Scarpa, Aldo, additional, Lawlor, Rita T., additional, Corbo, Vincenzo, additional, Bassi, Claudio, additional, and Dreyer, Stephan B., additional

Published
2022
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5. Expression of S100A2 Calcium-Binding Protein Predicts Response to Pancreatectomy for Pancreatic Cancer

Author

Biankin, Andrew V., Kench, James G., Colvin, Emily K., Segara, Davendra, Scarlett, Christopher J., Nguyen, Nam Q., Chang, David K., Morey, Adrienne L., Lee, C.–Soon, Pinese, Mark, Kuo, Samuel C.L., Susanto, Johana M., Cosman, Peter H., Lindeman, Geoffrey J., Visvader, Jane E., Nguyen, Tuan V., Merrett, Neil D., Warusavitarne, Janindra, Musgrove, Elizabeth A., Henshall, Susan M., and Sutherland, Robert L.

Published
2009
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7. Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer

Author

Dreyer, Stephan B., primary, Upstill-Goddard, Rosie, additional, Paulus-Hock, Viola, additional, Paris, Clara, additional, Lampraki, Eirini-Maria, additional, Dray, Eloise, additional, Serrels, Bryan, additional, Caligiuri, Giuseppina, additional, Rebus, Selma, additional, Plenker, Dennis, additional, Galluzzo, Zachary, additional, Brunton, Holly, additional, Cunningham, Richard, additional, Tesson, Mathias, additional, Nourse, Craig, additional, Bailey, Ulla-Maja, additional, Jones, Marc, additional, Moran-Jones, Kim, additional, Wright, Derek W., additional, Duthie, Fraser, additional, Oien, Karin, additional, Evers, Lisa, additional, McKay, Colin J., additional, McGregor, Grant A., additional, Gulati, Aditi, additional, Brough, Rachel, additional, Bajrami, Ilirjana, additional, Pettitt, Stephan, additional, Dziubinski, Michele L., additional, Candido, Juliana, additional, Balkwill, Frances, additional, Barry, Simon T., additional, Grützmann, Robert, additional, Rahib, Lola, additional, Johns, Amber, additional, Pajic, Marina, additional, Froeling, Fieke E.M., additional, Beer, Phillip, additional, Musgrove, Elizabeth A., additional, Petersen, Gloria M., additional, Ashworth, Alan, additional, Frame, Margaret C., additional, Crawford, Howard C., additional, Simeone, Diane M., additional, Lord, Chris, additional, Mukhopadhyay, Debabrata, additional, Pilarsky, Christian, additional, Tuveson, David A., additional, Cooke, Susanna L., additional, Jamieson, Nigel B., additional, Morton, Jennifer P., additional, Sansom, Owen J., additional, Bailey, Peter J., additional, Biankin, Andrew V., additional, Chang, David K., additional, Allison, Sarah, additional, Beraldi, Dario, additional, Cameron, Euan, additional, Dreyer, Stephan, additional, Grimwood, Paul, additional, Kelly, Shane, additional, Marshall, John, additional, Martin, Sancha, additional, McDade, Brian, additional, McElroy, Daniel, additional, Ramsay, Donna, additional, Wright, Derek, additional, Jones, Marc D., additional, Hair, Jane, additional, Westwood, Paul, additional, Williams, Nicola, additional, Johns, Amber L., additional, Mawson, Amanda, additional, Scarlett, Christopher J., additional, Brancato, Mary-Anne L., additional, Rowe, Sarah J., additional, Simpson, Skye H., additional, Martyn-Smith, Mona, additional, Thomas, Michelle T., additional, Chantrill, Lorraine A., additional, Chin, Venessa T., additional, Chou, Angela, additional, Cowley, Mark J., additional, Humphris, Jeremy L., additional, Mead, R. Scott, additional, Nagrial, Adnan M., additional, Pettit, Jessica, additional, Pinese, Mark, additional, Rooman, Ilse, additional, Wu, Jianmin, additional, Tao, Jiang, additional, DiPietro, Renee, additional, Watson, Clare, additional, Steinmann, Angela, additional, Lee, Hong Ching, additional, Wong, Rachel, additional, Pinho, Andreia V., additional, Giry-Laterriere, Marc, additional, Daly, Roger J., additional, Sutherland, Robert L., additional, Grimmond, Sean M., additional, Waddell, Nicola, additional, Kassahn, Karin S., additional, Miller, David K., additional, Wilson, Peter J., additional, Patch, Ann-Marie, additional, Song, Sarah, additional, Harliwong, Ivon, additional, Idrisoglu, Senel, additional, Nourbakhsh, Ehsan, additional, Manning, Suzanne, additional, Wani, Shivangi, additional, Gongora, Milena, additional, Anderson, Matthew, additional, Holmes, Oliver, additional, Leonard, Conrad, additional, Taylor, Darrin, additional, Wood, Scott, additional, Xu, Christina, additional, Nones, Katia, additional, Fink, J. Lynn, additional, Christ, Angelika, additional, Bruxner, Tim, additional, Cloonan, Nicole, additional, Newell, Felicity, additional, Pearson, John V., additional, Bailey, Peter, additional, Quinn, Michael, additional, Nagaraj, Shivashankar, additional, Kazakoff, Stephen, additional, Waddell, Nick, additional, Krisnan, Keerthana, additional, Quek, Kelly, additional, Wood, David, additional, Samra, Jaswinder S., additional, Gill, Anthony J., additional, Pavlakis, Nick, additional, Guminski, Alex, additional, Toon, Christopher, additional, Asghari, Ray, additional, Merrett, Neil D., additional, Pavey, Darren, additional, Das, Amitabha, additional, Cosman, Peter H., additional, Ismail, Kasim, additional, O’Connnor, Chelsie, additional, Lam, Vincent W., additional, McLeod, Duncan, additional, Pleass, Henry C., additional, Richardson, Arthur, additional, James, Virginia, additional, Kench, James G., additional, Cooper, Caroline L., additional, Joseph, David, additional, Sandroussi, Charbel, additional, Crawford, Michael, additional, Gallagher, James, additional, Texler, Michael, additional, Forest, Cindy, additional, Laycock, Andrew, additional, Epari, Krishna P., additional, Ballal, Mo, additional, Fletcher, David R., additional, Mukhedkar, Sanjay, additional, Spry, Nigel A., additional, DeBoer, Bastiaan, additional, Chai, Ming, additional, Zeps, Nikolajs, additional, Beilin, Maria, additional, Feeney, Kynan, additional, Nguyen, Nan Q., additional, Ruszkiewicz, Andrew R., additional, Worthley, Chris, additional, Tan, Chuan P., additional, Debrencini, Tamara, additional, Chen, John, additional, Brooke-Smith, Mark E., additional, Papangelis, Virginia, additional, Tang, Henry, additional, Barbour, Andrew P., additional, Clouston, Andrew D., additional, Martin, Patrick, additional, O’Rourke, Thomas J., additional, Chiang, Amy, additional, Fawcett, Jonathan W., additional, Slater, Kellee, additional, Yeung, Shinn, additional, Hatzifotis, Michael, additional, Hodgkinson, Peter, additional, Christophi, Christopher, additional, Nikfarjam, Mehrdad, additional, Mountain, Angela, additional, Biobank, Victorian Cancer, additional, Eshleman, James R., additional, Hruban, Ralph H., additional, Maitra, Anirban, additional, Iacobuzio-Donahue, Christine A., additional, Schulick, Richard D., additional, Wolfgang, Christopher L., additional, Morgan, Richard A., additional, Hodgin, Mary, additional, Scarpa, Aldo, additional, Lawlor, Rita T., additional, Beghelli, Stefania, additional, Corbo, Vincenzo, additional, Scardoni, Maria, additional, Bassi, Claudio, additional, Tempero, Margaret A., additional, and Graham, Janet S., additional

Published
2021
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9. Reply

Author

Biankin, Andrew V., Kench, James G., Henshall, Susan M., and Sutherland, Robert L.

Published
2002
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10. Expression of S100A2 calcium-binding protein predicts response to pancreatectomy for pancreatic cancer

Author

Samuel C. L. Kuo, David K. Chang, James G. Kench, Adrienne Morey, Mark Pinese, Peter H. Cosman, Jane E. Visvader, Tuan V. Nguyen, Susan M. Henshall, Janindra Warusavitarne, C. Soon Lee, Christopher J. Scarlett, Davendra Segara, Andrew V. Biankin, Johana M. Susanto, Neil D. Merrett, Geoffrey J. Lindeman, Emily K. Colvin, Robert L. Sutherland, Nam Q. Nguyen, and Elizabeth A. Musgrove

Subjects
Oncology, Male, Pathology, Time Factors, medicine.medical_treatment, Kaplan-Meier Estimate, Cohort Studies, Postoperative Complications, Lymph node, Aged, 80 and over, Predictive marker, Hazard ratio, S100 Proteins, Gastroenterology, Middle Aged, Gene Expression Regulation, Neoplastic, Survival Rate, medicine.anatomical_structure, Treatment Outcome, Tumor Markers, Biological, Predictive value of tests, Pancreatectomy, Female, Adult, medicine.medical_specialty, Adenocarcinoma, Risk Assessment, Sensitivity and Specificity, Disease-Free Survival, Predictive Value of Tests, Internal medicine, Pancreatic cancer, medicine, Biomarkers, Tumor, Confidence Intervals, Humans, Survival rate, Aged, Neoplasm Staging, Probability, Proportional Hazards Models, Gastroenterology & Hepatology, Hepatology, business.industry, Proportional hazards model, medicine.disease, Pancreatic Neoplasms, business, Follow-Up Studies
Abstract

Background & Aims: Current methods of preoperative staging and predicting outcome following pancreatectomy for pancreatic cancer (PC) are inadequate. We evaluated the utility of multiple biomarkers from distinct biologic pathways as potential predictive markers of response to pancreatectomy and patient survival. Methods: We assessed the relationship of candidate biomarkers known, or suspected, to be aberrantly expressed in PC, with disease-specific survival and response to therapy in a cohort of 601 patients. Results: Of the 17 candidate biomarkers examined, only elevated expression of S100A2 was an independent predictor of survival in both the training (n = 162) and validation sets (n = 439; hazard ratio [HR], 2.19; 95% confidence interval [CI]: 1.48-3.25; P < .0001) when assessed in a multivariate model with clinical variables. Patients with high S100A2 expressing tumors had no survival benefit with pancreatectomy compared with those with locally advanced disease, whereas those without high S100A2 expression had a survival advantage of 10.6 months (19.4 vs 8.8 months, respectively) and a HR of 3.23 (95% CI: 2.39-4.33; P < .0001). Of significance, patients with S100A2-negative tumors had a significant survival benefit from pancreatectomy even in the presence of involved surgical margins (median, 15.7 months; P = .0007) or lymph node metastases (median, 17.4 months; P = .0002). Conclusions: S100A2 expression is a good predictor of response to pancreatectomy for PC and suggests that high S100A2 expression may be a marker of a metastatic phenotype. Prospective measurement of S100A2 expression in diagnostic biopsy samples has potential clinical utility as a predictive marker of response to pancreatectomy and other therapies that target locoregional disease. © 2009 AGA Institute.

Published
2008

11. Insulin resistance is associated with chronic hepatitis C virus infection and fibrosis progression [corrected]

Author

Jason M, Hui, Archana, Sud, Geoffrey C, Farrell, Priyanka, Bandara, Karen, Byth, James G, Kench, Geoffrey W, McCaughan, and Jacob, George

Subjects
Adult, Liver Cirrhosis, Male, Adolescent, Genotype, Biopsy, Hepatitis C, Chronic, Middle Aged, Fatty Liver, Liver, Disease Progression, Humans, Female, Insulin Resistance, Aged
Abstract

Chronic hepatitis C virus infection is associated with an increased prevalence of type 2 diabetes. We hypothesized that virus-induced insulin resistance may be a mechanism for fibrogenesis in chronic hepatitis C virus infection.In 260 hepatitis C virus-infected subjects, we examined the relationship between histological findings and anthropometric and biochemical data, including insulin resistance determined by the homeostasis model assessment (HOMA-IR). We also compared fasting serum insulin, C peptide, and HOMA-IR levels between the subset of 121 hepatitis C virus patients with stage 0 or 1 hepatic fibrosis and 137 healthy volunteers matched by sex, body mass index, and waist-hip ratio.Hepatitis C virus-infected subjects with stage 0 or 1 hepatic fibrosis had higher levels of insulin, C peptide, and HOMA-IR (all Por = 0.01) compared with matched healthy controls. In the 250 hepatitis C virus patients (fibrosis stage 0 to 4), viral genotype and portal, but not lobular, inflammation were univariate predictors of HOMA-IR. By multiple linear regression analysis, independent predictors of HOMA-IR included body mass index (P0.001), previous failed antiviral treatment (P0.001), portal inflammatory grade (P0.001), and genotype 3 status (P = 0.01). Genotype 3 had significantly lower HOMA-IR than other genotypes (which were comparable when adjusted for effects of the remaining independent predictors). HOMA-IR was an independent predictor for the degree of fibrosis (P0.001) and the rate of fibrosis progression (P = 0.03).Hepatitis C virus may induce insulin resistance irrespective of the severity of liver disease, and this effect seems to be genotype specific. Further, our findings support the hypothesis that insulin resistance may contribute to fibrotic progression in chronic hepatitis C virus infection.

Published
2004

17. 314 The Novel Biomarker (HOXB2) Predicts Response to Pancreatectomy for Pancreatic Cancer

Author

Nam Q. Nguyen, James G. Kench, Neil D. Merrett, Sandra A. Biankin, Andrew V. Biankin, Robert L. Sutherland, Elizabeth A. Musgrove, David A. Skalicky, Susan M. Henshall, and Devendra Segara

Subjects
Oncology, medicine.medical_specialty, Hepatology, business.industry, medicine.medical_treatment, Gastroenterology, medicine.disease, Internal medicine, Pancreatic cancer, Pancreatectomy, Biomarker (medicine), Medicine, CA19-9, business
Published
2008
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18. Reply

Author

Andrew V. Biankin, James G. Kench, Susan M. Henshall, and Robert L. Sutherland

Subjects
Hepatology, Gastroenterology
Published
2002
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